- Ubiquitin Ligases in Cholesterol Metabolism
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Jiang W, Song BL
- KMID: 2280686
- Diabetes Metab J.
- 2014 Jun;38(3):171-180.
- doi: 10.4093/dmj.2014.38.3.171
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players... -
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- Analysis of the Structure-stability Relationship of Cold-adapted Lipase PsLip1 from Homology Modeling
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Choo D
- KMID: 2053267
- Genomics Inform.
- 2011 Jun;9(2):79-84.
Two initial models of cold-adapted lipase PsLip1 have been constructed, based on homology with the bacterial lipases Chromobacterium viscosum(CvLip) and Pseudomonas cepacia(PcLip), whose X-ray structures have been solved and refined... -
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- The Effects of Bear Bile on the Expression of the p53 Protein in Cancer Cell Lines
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Jin Y, Moon YS, Jeong HS, Choi IJ
- KMID: 2030771
- Korean J Anat.
- 2005 Feb;38(1):49-54.
The effects of bear bile on the expression of the p53 protein in cancer cell lines were investigated by Western blot and RT-PCR methods. The p53 protein expression was increased... -
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- Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran
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Golmohammadi R, Namazi MJ, Nikbakht M, Salehi M, Derakhshan MH
- KMID: 1431344
- Gut Liver.
- 2013 May;7(3):295-302.
- doi: 10.5009/gnl.2013.7.3.295
BACKGROUND/AIMS: We aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central... -
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- F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
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Lee KW, Kwak SH, Koo YD, Cho YK, Lee HM, Jung HS, Cho YM, Park YJ, Chung SS, Park KS
- KMID: 2361521
- Exp Mol Med.
- 2016 May;48(5):e234.
- doi: 10.1038/emm.2016.31
Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PPARγ and its degradation involve several pathways, including... -
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- Long-Term Stability of Selected Serum Biomarkers in Leftover Samples
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Park BG, Ihm C, Sohn YH, Choi EH
- KMID: 2200494
- J Lab Med Qual Assur.
- 2013 Dec;35(2):122-132.
BACKGROUND: The purpose of this study was to assess the quality of long-term-stored leftover blood samples, and to evaluate the long-term stability of selected serum biomarkers such as proteins, enzymes,... -
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- Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3
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Lee K, Kim H, Lee J, Oh CM, Song H, Kim H, Koo SH, Lee J, Lim A, Kim H
- KMID: 2460958
- Diabetes Metab J.
- 2019 Oct;43(5):649-658.
- doi: 10.4093/dmj.2018.0232
BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the... -
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- Radiolabeling of NOTA and DOTA with Positron Emitting 68Ga and Investigation of In Vitro Properties
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Jeong JM, Kim YJ, Lee YS, Lee DS, Chung JK, Lee MC
- KMID: 2313109
- Nucl Med Mol Imaging.
- 2009 Aug;43(4):330-336.
PURPOSE: We established radiolabeling conditions of NOTA and DOTA with a generator-produced PET radionuclide 68Ga and studied in vitro characteristics such as stability, serum protein binding, octanol/water distribution, and interference... -
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- In vitro Stability of Heat Shock Protein 27 in Serum and Plasma Under Different Pre-analytical Conditions: Implications for Large-Scale Clinical Studies
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Zimmermann M, Traxler D, Simader E, Bekos C, Dieplinger B, Lainscak M, Ankersmit , Mueller T
- KMID: 2373555
- Ann Lab Med.
- 2016 Jul;36(4):353-357.
- doi: 10.3343/alm.2016.36.4.353
The effects of storage temperatures, repeated freeze-thaw cycles, or delays in separating plasma or serum from blood samples are largely unknown for heat shock protein 27 (HSP27). We evaluated (1)... -
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- Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription
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Lee J, Chun SK, Son GH, Kim K
- KMID: 2407090
- Endocrinol Metab.
- 2015 Sep;30(3):381-388.
- doi: 10.3803/EnM.2015.30.3.381
BACKGROUND: Hes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we... -
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- Effects of Cofactor Tetrahydrobiopterin and Deletions on the Regulatory Domain of Tyrosine Hydroxylase on the Expression of Tyrosine Hydroxylase
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Cho YW, Yi SD, Lim JK, Lee H, Kim YS, Lee U, Lee YJ
- KMID: 2342930
- J Korean Neurol Assoc.
- 2001 Sep;19(5):514-519.
BACKGROUND: For the treatment of Parkinson's disease, dopamine-producing cells or genes involved in producing dopamine or supporting neurons have been tested to replace conventional chemical therapies. Of these, tyrosine hydroxylase... -
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- New Aspects of Vascular Calcification: Histone Deacetylases and Beyond
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Kwon DH, Kim YK, Kook H
- KMID: 2390298
- J Korean Med Sci.
- 2017 Nov;32(11):1738-1748.
- doi: 10.3346/jkms.2017.32.11.1738
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases,... -
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- Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
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Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H
- KMID: 2458551
- Exp Neurobiol.
- 2019 Aug;28(4):537-546.
- doi: 10.5607/en.2019.28.4.537
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NADâº-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins... -
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- A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
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Kim JW, Kim TD, Hong BS, Kim OY, Yoon WH, Chae CB, Gho YS
- KMID: 1104211
- Exp Mol Med.
- 2010 Jul;42(7):514-523.
- doi: 10.3858/emm.2010.42.7.052
Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for... -
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- Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state
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Park IH, Kim KH, Choi HK, Shim JS, Whang SY, June Hahn , Kwon OJ, Oh IH
- KMID: 2154263
- Exp Mol Med.
- 2013 Sep;45(9):e44.
With the increasing use of culture-expanded mesenchymal stromal cells (MSCs) for cell therapies, factors that regulate the cellular characteristics of MSCs have been of major interest. Oxygen concentration has been... -
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