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Identification of Leukemia Surface Proteins Using a Proteomic Technique

Park JI, Kim HI, Lee HW, Kang SY, Jang JH, Park JS, Choi JH, Lim HY, Kim HC

BACKGROUND: Numerous cell surface proteins of leukemia cells such as CD33 and CD52 have been identified as diagnostic and therapeutic targets. Thus the profiling of the cell surface proteome and...
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Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway

Li S, Li C, Ryu HH, Lim SH, Jang WY, Jung S

OBJECTIVE: Protein disulfide isomerase (PDI) acts as a chaperone on the cell surface, and it has been reported that PDI is associated with the tumor cell migration and invasion. The...
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A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase

Yu SJ, Won JK, Ryu HS, Choi WM, Cho H, Cho EJ, Lee JH, Kim YJ, Suh KS, Jang JJ, Kim CY, Lee HS, Yoon JH, Cho KH

BACKGROUND/AIMS: Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its...
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Membrane Proteome Analysis of Cerulein-Stimulated Pancreatic Acinar Cells: Implication for Early Event of Acute Pancreatitis

Lee J, Seo JH, Lim JW, Kim H

  • KMID: 2167210
  • Gut Liver.
  • 2010 Mar;4(1):84-93.
BACKGROUND/AIMS: Cerulein pancreatitis is similar to human edematous pancreatitis with dysregulation of the production and secretion of digestive enzymes, edema formation, cytoplasmic vacuolization and the death of acinar cells. We...
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PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis

Kim HK, Lee GH, Bhattarai , Junjappa R, Lee HY, Handigund , Marahatta , Bhandary B, Baek IH, Pyo JS, Kim HK, Chai OH, Kim HR, Lee YC, Chae HJ

Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have been examined as asthma therapeutics. However,...
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