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Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients

Thompson K, Rainer BM, Antonescu , Florea L, Mongodin E, Kang S, Chien AL

BACKGROUND: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. OBJECTIVE: We performed a case-control study...
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Efficacy of Bacteriophages in Propionibacterium acnes-Induced Inflammation in Mice

Kim MJ, Eun DH, Kim SM, Kim J, Lee WJ

BACKGROUND: Bacteriophages have been introduced as living drugs for infectious diseases; thus, they may provide an alternative to conventional acne therapeutics in patients with non-responsive acne. OBJECTIVE: We investigated the effect...
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Iatrogenic pleural empyema caused by Propionibacterium acnes

Jwa H, Lee J, Seong GM, Kim C

Propionibacterium acnes is one of the commensals living on the human skin and glands, implicated mainly in acnes, but seldom in deep infection. Pleural empyema is rarely complicated with closed...
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Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles

Kim MH, Choi SJ, Choi HI, Choi JP, Park HK, Kim EK, Kim MJ, Moon BS, Min TK, Rho M, Cho YJ, Yang S, Kim YK, Kim YY, Pyun BY

PURPOSE: The microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles...
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Epidermal Growth Factor Attenuated the Expression of Inflammatory Cytokines in Human Epidermal Keratinocyte Exposed to Propionibacterium acnes

Kim JM, Choo JE, Lee HJ, Kim KN, Chang SE

BACKGROUND: While the beneficial effects of topical epidermal growth factor (EGF) on wound healing have been repeatedly reported, there are few reports about the effects of EGF on inflammatory skin...
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Pharmacological treatment options for acne

Park KY

Acne vulgaris is a very common condition affecting up of about 80% to 90% of adolescents. The patients with acne have been shown to be adversely impacted by the effect...
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The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients

Kim HJ, Kim YS, Kim KH, Choi JP, Kim YK, Yun S, Sharma L, Dela Cruz , Lee JS, Oh YM, Lee SD, Lee SW

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, and bacterial infection plays a role in its pathogenesis. Bacteria secrete nanometer-sized extracellular vesicles (EVs), which may induce more immune...
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Influence of Chemical- and Natural-Based Lotions on Bacterial Communities in Human Forearm Skin

Park DH

Purpose of this study was to evaluate the influence of a lotion on the bacterial community in the human forearm skin. The chemical- and natural-based lotions were applied on the...
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G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes

Park AJ, Agak GW, Qin M, Hisaw LD, Pirouz A, Kao S, Marinelli , Garbán HJ, Thiboutot , Liu PT, Kim J

BACKGROUND: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by...
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Antimicrobial Susceptibility and Characterization of Propionibacterium acnes by Multilocus Sequence Typing and Repetitive-Sequence-Based PCR

Kim S, Song H, Lee WJ, Kim J

Propionibacterium acnes, a gram-positive, anaerobic, and aerotolerant bacterium that is found frequently in the skin as part of the human microbiome causes inflammatory acne, shoulder infection, and the contamination of...
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Lung Microbiome Analysis in Steroid-NaÑ—ve Asthma Patients by Using Whole Sputum

Jung JW, Choi JC, Shin JW, Kim JY, Park IW, Choi BW, Park HW, Cho SH, Kim K, Kang HR

BACKGROUND: Although recent metagenomic approaches have characterized the distinguished microbial compositions in airways of asthmatics, these results did not reach a consensus due to the small sample size, non-standardization of...
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Efficacy of Red or Infrared Light-Emitting Diodes in a Mouse Model of Propionibacterium acnes-Induced Inflammation

Lee WJ, Lee KC, Kim MJ, Jang YH, Lee SJ, Kim DW

BACKGROUND: Laser/light-based devices may provide an alternative to conventional acne therapeutics in some patients with nonresponsive acne. OBJECTIVE: We investigated the efficacy of red or infrared light-emitting diode (LED) devices in...
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Effects of Magnesium Ascorbyl Phosphate on the Expression of Inflammatory Biomarkers after Treatment of Cultured Sebocytes with Propionibacterium acnes or Ultraviolet B Radiation

Lee WJ, Kim SL, Lee KC, Sohn MY, Jang YH, Lee SJ, Kim DW

No abstract available.
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Identification of Non-Aggregatibacter actinomycetemcomitans Bacteria Grown on the Tryptic soy-Serum-Bacitracin-Vancomycin Medium

Jo E, Park SN, Kook JK

The aim of this study was to identify the non-Aggregatibacter actinomycetemcomitans bacteria grown on the tryptic soy-serum-bacitracin-vancomycin (TSBV) medium, an A. actinomycetemcomitans selective medium. A total of 82 unidentified bacterial...
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Effect of Vitamin D on the Expression of Inflammatory Biomarkers in Cultured Sebocytes Treated with Propionibacterium acnes or Ultraviolet B Irradiation

Lee WJ, Kim MJ, Ryu HS, Sohn MY, Jang YH, Lee SJ, Kim DW

No abstract available.
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HR-1 Mice: A New Inflammatory Acne Mouse Model

Jang YH, Lee KC, Lee SJ, Kim DW, Lee WJ

BACKGROUND: There is no appropriate in vivo animal model that reflects the inflammatory response of human acne. OBJECTIVE: This study investigated the effect of Propionibacterium acnes on the development of inflammatory...
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Inflammatory Cytokine Expression and Sebum Production after Exposure of Cultured Human Sebocytes to Ultraviolet A Radiation and Light at Wavelengths of 650 nm and 830 nm

Lee WJ, Chae SY, Ryu HS, Jang YH, Lee SJ, Kim DW

BACKGROUND: The effectiveness of ultraviolet (UV) radiation, visible light, or infrared light therapy for the treatment of acne is the subject of ongoing scientific debate. OBJECTIVE: This study was conducted to...
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Clinicopathologic Features of Progressive Macular Hypomelanosis in Korea

Lee HS, Sohn S, Kang HY, Lee ES, Kim YC

  • KMID: 2246225
  • Korean J Dermatol.
  • 2015 Feb;53(2):113-118.
BACKGROUND: Progressive macular hypomelanosis, a disease of uncertain etiology, was first described by Guillet et al. in 1988. It is characterized by asymptomatic hypopigmented macules and patches that appear on...
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Misidentification of Brevibacterium casei as Propionibacterium acnes Isolated from the Blood of a Patient with Malignant Lymphoma

Jung YJ, Huh HJ, Ki CS, Lee NY

Brevibacterium spp. are Gram-positive, irregularly rod-shaped, strictly aerobic bacteria that resemble corynebacteria. Since they are a part of normal skin flora, they have been regarded as apathogenic, and human infections...
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Microbial Profile of the Stomach: Comparison between Normal Mucosa and Cancer Tissue in the Same Patient

Seo I, Jha BK, Suh SI, Suh MH, Baek WK

Gastric cancer is the third most common cancer and the third most frequent cause of cancer mortality in Asia. It is predicted that gastric cancer will remain an important cause...
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