Ann Dermatol.  2016 Feb;28(1):129-132. 10.5021/ad.2016.28.1.129.

Effects of Magnesium Ascorbyl Phosphate on the Expression of Inflammatory Biomarkers after Treatment of Cultured Sebocytes with Propionibacterium acnes or Ultraviolet B Radiation

• Lee WJ
• Kim SL
• Lee KC
• Sohn MY
• Jang YH
• Lee SJ
• Kim DW

• KMID: 2429501
• DOI: http://doi.org/10.5021/ad.2016.28.1.129

Abstract

No abstract available.

MeSH Terms

Biomarkers*
Magnesium*
Propionibacterium acnes*
Propionibacterium*
Magnesium

Figure

• 

  Fig. 1 (A~D) The gene expression of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor α (TNF-α) after the treatment of cultured sebocytes with magnesium ascorbyl phosphate (MAP, 10−2 M), Propionibacterium acnes (1010 CFU/µl), or a combination of MAP (10−2 M) and P. acnes (1010 CFU/µl). (A'~D') The protein expression of IL-1β, IL-6, IL-8 and TNF-α after the treatment of cultured sebocytes with MAP (10−2 M), P. acnes (1010 CFU/µl), or a combination of MAP (10−2 M) and P. acnes (1010 CFU/µl). MAP inhibited the upregulation of IL-1β expression in cultured sebocytes induced by P. acnes. MAP did not inhibit the P. acnes-induced increase in the expression of IL-6, IL-8, and TNF-α after the treatment of cultured sebocytes with P. acnes. (E~H) The gene expression of IL-1β, IL-6, IL-8 and TNF-α after the treatment of cultured sebocytes with MAP (10−2 M) and 40 mJ/cm2 ultraviolet B (UVB) radiation. (E'~H') The protein expression of IL-1β, IL-6, IL-8 and TNF-α after the treatment of cultured sebocytes with MAP (10−2 M) and 40 mJ/cm2 UVB radiation. MAP decreased the expression of IL-1β in cultured sebocytes 1, 3, and 5 days after exposure to 40 mJ/cm2 UVB radiation. Cultured sebocytes treated with MAP did not show a decrease in the expression of IL-6, IL-8 and TNF-α after exposure to 40 mJ/cm2 UVB radiation. Cont: control.

• 

  Fig. 2 Lipid peroxidation in cultured sebocytes. Magnesium ascorbyl phosphate (MAP, 10−2 M) decreased the levels of lipid peroxidation after the treatment of cultured sebocytes with Propionibacterium acnes (1010 CFU/µl) (A) or 40 mJ/cm2 UVB radiation (B). Cont: control.

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