Ann Dermatol.  2016 Oct;28(5):665-669. 10.5021/ad.2016.28.5.665.

Effect of Vitamin D on the Expression of Inflammatory Biomarkers in Cultured Sebocytes Treated with Propionibacterium acnes or Ultraviolet B Irradiation

• Lee WJ
• Kim MJ
• Ryu HS
• Sohn MY
• Jang YH
• Lee SJ
• Kim DW

• KMID: 2382903
• DOI: http://doi.org/10.5021/ad.2016.28.5.665

Abstract

No abstract available.

MeSH Terms

Biomarkers*
Propionibacterium acnes*
Propionibacterium*
Vitamin D*
Vitamins*
Biomarkers
Vitamin D
Vitamins

Figure

• 

  Fig. 1 Effect of vitamin D on the expression of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α in cultured sebocytes after treatment with Propionibacterium acnes or ultraviolet B (UVB) irradiation. (A~C) Protein expression of IL-1β, IL-6, and IL-8 (*p<0.05) in cultured sebocytes treated with 1010 CFU/µl P. acnes decreased with the treatment of 10-6 M vitamin D. (D) Protein expression of TNF-α in cultured sebocytes treated with 1010 CFU/µl P. acnes did not decrease with the treatment of 10-6 M vitamin D. (E~H) Protein expression of IL-1β, IL-6 (*p<0.05), IL-8, and TNF-α in cultured sebocytes treated with 40 mJ/cm2 or 70 mJ/cm2 UVB showed more decreasing tendency after the addition of 10-6 M vitamin D compared with 10-8 M vitamin D. (E, F, H) Upregulation of IL-1β, IL-6, and TNF-α in cultured sebocytes by 40 mJ/cm2 UVB was inhibited 1 day after treatment with 10-6 M vitamin D compared with control.

• 

  Fig. 2 Sebum production by cultured sebocytes after treatment with Propionibacterium acnes (1010 CFU/µl) was decreased by treatment with 10-6 M vitamin D. However, sebum production was increased by P. acnes (1010 CFU/µl) or 10-6 M vitamin D. There was no statistically significant difference in sebum production among the treated groups.

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