- A Novel Presenilin Gene 1 Mutation in Early Onset Familial Alzheimer's Disease
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Yoo S, Kim S, Bae DW, Kim JS, Kim JW, Lee KS
- KMID: 2343566
- J Korean Neurol Assoc.
- 2014 Nov;32(4):323-325.
- doi: 10.0000/jkna.2014.32.4.323
No abstract available. -
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- Animal Models of Alzheimer's Dementia
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Woo SI
- KMID: 2334613
- J Korean Soc Biol Psychiatry.
- 1999 Nov;6(2):149-152.
Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and... -
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- A Newer Therapeutic Strategies For Alzheimer's Disease
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Han SH
- KMID: 2185998
- J Korean Neurol Assoc.
- 2001 Nov;19(6):559-565.
Alzheimer's disease (AD) is characterized pathologically by cholinergic deficits, extracelluar amyloid deposit, intra-neuronal neurofibrillary tangles, gliosis and neuronal and synaptic loss. The primary therapeutic approach has been cholinergic augumentation by... -
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- Molecular Genetic Aspects of Alzheimer's Disease
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Han SH
- KMID: 2416590
- J Korean Med Assoc.
- 2002 Apr;45(4):378-384.
- doi: 10.5124/jkma.2002.45.4.378
Alzheimer's disease (AD), the cause of one of the most common types of dementia, is pathologically characterized by cholinergic deficits, extracellular amyloid deposit, intraneuronal neurofibrillary tangles, gliosis, and neuronal and... -
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- Pathogenesis of Alzheimer's Dementia
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Suh YH
- KMID: 2184701
- J Korean Med Assoc.
- 2006 Aug;49(8):717-730.
- doi: 10.5124/jkma.2006.49.8.717
Alzhelmer's disease (AD) is the most common cause of dementia that arises on a neuropathological background of amyloid plaques containing betaamylold (Abeta) derived from amyloid precursor protein (APP) and tau-rich... -
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- Comprehensive MicroRNAome Analysis of the Relationship Between Alzheimer Disease and Cancer in PSEN Double-Knockout Mice
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Ham S, Kim TK, Ryu J, Kim YS, Tang YP, Im HI
- KMID: 2431864
- Int Neurourol J.
- 2018 Dec;22(4):237-245.
- doi: 10.5213/inj.1836274.137
PURPOSE: Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer... -
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- Molecular Neurobiology of Alzheimer's Disease
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Kim YH, Rhee CG, Kim YK, Kim SS
- KMID: 2333738
- J Korean Geriatr Psychiatry.
- 1998 May;2(1):37-46.
Alzheimer's disease (AD), the most common dementia in the elderly, is associated with a characteristic neuropathology:extracellular neuritic plaques (NPs) and intraneuronal neurofibrillary tangles (NFTs). AD is diagnosed clinically on the... -
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- Regulation of DREAM Expression by Group I mGluR
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Lee J, Kim I, Oh SR, Ko SJ, Lim MK, Kim DG, Kim CH
- KMID: 2285413
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):95-100.
- doi: 10.4196/kjpp.2011.15.2.95
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no... -
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- Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice
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Kim EJ, Yang SJ
- KMID: 2383701
- Clin Nutr Res.
- 2017 Apr;6(2):130-135.
- doi: 10.7762/cnr.2017.6.2.130
The purpose of this study is to investigate whether nicotinic acid (NA) and nicotinamide (NAM) reduce the Alzheimer disease (AD)-related gene expression in brain tissues of amyloid beta (Aβ)-injected mice.... -
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- Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice
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Yun WB, Park JJ, Kim JE, Sung JE, Lee HA, Lee JH, Bae CJ, Hwang DY
- KMID: 2362917
- Lab Anim Res.
- 2016 Dec;32(4):249-256.
- doi: 10.5625/lar.2016.32.4.249
Alzheimer's disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the... -
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- Purification and Identification of Ubiquitin Binding Proteins from Erythrocytes of Patients with Dementia
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Kim HS, Cheon JS, Oh BH, Lee SJ
- KMID: 2186206
- J Korean Geriatr Psychiatry.
- 2003 Jun;7(1):57-66.
OBJECTIVE: The continuous synthesis and degradation of proteins in the cell are essential for the maintenance of cellular homeostasis. Intracellular protein degradation largely occurs in the lysosome and cytoplasm. The... -
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