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Molecular characterisation of pancreatic zymogen granule ion channel and regulator proteins involved in exocytosis

Thevenod F, Braun M, Roussa E, Fuller CM

In pancreatic acinar cells Ca(2+)-dependent secretagogues promote the fusion of zymogen granules (ZG) with the apical plasma membrane (PM) and exocytosis of digestive enzymes. In addition to exocytotic fusion complexes...
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The Role of Serotonin in Ventricular Repolarization in Pregnant Mice

Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B

PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role...
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Type 2 Diabetes Induces Prolonged P-wave Duration without Left Atrial Enlargement

Li B, Pan Y, Li X

Prolonged P-wave duration has been observed in diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to elucidate the possible mechanisms. A rat model of type...
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Suppression of CFTR-mediated Cl- Secretion of Airway Epithelium in Vitamin C-deficient Mice

Kim Y, Kim H, Yoo HY, Kang JS, Kim SJ, Kim JK, Cho HS

Hyperoxic ventilation induces detrimental effects on the respiratory system, and ambient oxygen may be harmful unless compensated by physiological anti-oxidants, such as vitamin C. Here we investigate the changes in...
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