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Phytoestrogens and Bone Metabolism

Jeon GH, Kang BM

  • KMID: 2314139
  • Osteoporosis.
  • 2013 Dec;11(3):105-113.
Although most gynecologists had prescribed estrogen with or without progestin for their menopausal patients before the publication of Women's health Initiative (WHI) trial findings, only 35 to 40% of women...
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Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models

Kim SH, Choi KC

  • KMID: 2317840
  • Toxicol Res.
  • 2013 Dec;29(4):229-234.
Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long times, phytoestrogens have been used for therapeutic treatments against human diseases, and they can be promising ingredients...
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Comparison of Anti-osteoporotic Medications and Alternatives

Kang BM

  • KMID: 2272985
  • Korean J Obstet Gynecol.
  • 2006 Dec;49(12):2459-2472.
Osteoporosis becomes a serious health threat for aging postmenopausal women by predisposing them to an increased risk of fracture. Conventional pharmacological options are available for osteoporosis therapy, including bisphosphonates, the...
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Effects of phytoestrogen on sexual development

Kim SH, Park MJ

Phytoestrogen is an estrogenic compound that occurs naturally in plants. The most common sources of phytoestrogen are soybean products, which contain high levels of isoflavones. This compound, which has structural...
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Phytoestrogen-Induced Phosphorylation of MAP Kinase in Osteoblasts is Mediated by Membrane Estrogen Receptor

Park YH, Park HK, Lee HJ, Park SM, Choi SW, Lee WJ

  • KMID: 2285247
  • Korean J Physiol Pharmacol.
  • 2002 Jun;6(3):165-170.
We have previously demonstrated that phytoestrogens isolated from safflower seeds significantly attenuated bone loss in ovariectomized rats, and directly stimulated proliferation and differentiation of cultured osteoblastic cells. In an attempt...
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Effect of Phytoestrogen on Depression and Anxiety in Menopausal Women: A Systematic Review

Fattah A

OBJECTIVES: In this systematic review, the effectiveness of herbal medicines in improving depression and anxiety in menopausal women was assessed. METHODS: Three following databases were individually searched: MEDLINE (1966-March 2017), SCOPUS...
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Diverse animal models to examine potential role(s) and mechanism of endocrine disrupting chemicals on the tumor progression and prevention: Do they have tumorigenic or anti-tumorigenic property?

Park MA, Hwang KA, Choi KC

Acting as hormone mimics or antagonists in the interaction with hormone receptors, endocrine disrupting chemicals (EDCs) have the potentials of disturbing the endocrine system in sex steroid hormone-controlled organs and...
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Effects of Phytoestrogens on Glucose Metabolism in C57BL/KsOlaHsd-db/db Mice

Seo BH, Kim KO, Lee JH, Lee HS

This study was conducted to evaluate the antihyperglycemic effects of three phytoestrogens, genistein, coumestrol, and enterolactone, in type 2 diabetic animals. Forty male C57BL/KsOlaHsd-db/db mice were used as a diabetic...
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Effects of Estrogens and Isoflavones on the Collagen Synthesis

Kim BG, Oh CK, Jo JH, Lee JB, Kim MB, Jang HS, Kwon KS

  • KMID: 2038622
  • Korean J Dermatol.
  • 2003 Aug;41(8):1041-1048.
BACKGROUND: The aging of skin is influenced by genetic, environmental, and hormonal factors. Estrogens are the "missing" player in the skin of postmenopausal women. In postmenopausal women, loss of collagen...
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Endocrine Disruptor and Menopause

Kim TH, Hong YP

  • KMID: 1853320
  • J Korean Soc Menopause.
  • 2010 Apr;16(1):1-5.
An endocrine disruptor is an exogenous substance or mixture that alters the function of the endocrine system and causes adverse health effects in the population and progeny. Estrogen is an...
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Study on the Role of Estrogen Receptor-Alpha in Yak-Kong and Soybean Induced Proliferation of MG-63 Human Osteoblastic Cells

Um SJ, Kang IS, Cho Y

  • KMID: 2269895
  • Korean J Nutr.
  • 2005 Sep;38(7):512-520.
Phytoestrogens, especially Yak-kong or soybean-derived isoflavones have been traditionally used as a supplement of estrogen for preventing postmenopausal osteoporosis in oriental folk medicine. In a previous study, we demonstrated that...
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Survey on the Consumption of the Phytoestrogen Isoflavone in Postmenopausal Korean Women

Lee JH, Heo JM, Park YS, Park HM

  • KMID: 2321329
  • J Korean Soc Menopause.
  • 2012 Dec;18(3):163-173.
OBJECTIVES: Isoflavone is a plant-derived compound, abundant in soy food, and its character is mixed estrogenic and antiestrogenic action, so it is highlighted as an alternative to hormone replacement therapy...
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Effect of Herbal Medicine on Vaginal Epithelial Cells: A Systematic Review and Meta-analysis

Rahmani Y, Chaleh KC, Shahmohammadi A, Safari S

OBJECTIVES: The present meta-analysis aimed to assess the effect of the herbal medicine on the vaginal epithelial cells (VECs) among the menopausal subjects. METHODS: The literature related to VECs exposed to...
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Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells

Lee GA, Choi KC, Hwang KA

Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3′-diindolylmethane (DIM) are phytoestrogens that play...
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Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models

Kim SH, Kim CW, Jeon SY, Go RE, Hwang KA, Choi KC

Genistein is one of isoflavones mostly derived in a leguminous plant. It is well known as one of phytoestrogens that have structures similar to the principal mammalian estrogen. It has...
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Phytoestrogen (Daidzein) Promotes Chondrogenic Phenotype of Human Chondrocytes in 2D and 3D Culture Systems

Mahmod SA, Snigh S, Djordjevic I, Yee YM, Yusof R, Ramasamy T, Rothan HA

Clinical investigations have shown a significant relationship between osteoarthritis (OA) and estrogens levels in menopausalwomen. Therefore, treatment with exogenous estrogens has been shownto decrease the risk ofOA.However, the effect estrogen...
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Foeniculum vulgare as Valuable Plant in Management of Women's Health

Mahboubi M

This review paper evaluates use of Foeniculum vulgare extracts as a popular female plant in management of different ailments of women. Information in this paper was gathered from accessible sources...
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Perspectives for Managing Menopause: General Introduction

Oh HJ

Menopause is very important for women causes of many health problems are related. Hormone Replacement Therapy (HRT) is so common to treat symptoms of menopause. It is important that benefits...
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The efficacy of phytoestrogen in postmenopausal women

Park HM

  • KMID: 1870350
  • Korean J Obstet Gynecol.
  • 2007 Mar;50(3):389-415.
Phytoestrogen is a group of phytochemicals called phenolic compounds. Phytoestrogen may be functionally or structurally related to estrogens, resulting in agonistic and antagonistic activity depending upon the tissues. Phytoestrogen may...
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The Study of Pytoestrogen Intake and Bone Mineral Density of Vegetarian and Nonvegetarian Postmenopausal Women

Kim MH, Choi MK, Sung CJ

  • KMID: 2232876
  • Korean J Community Nutr.
  • 2004 Feb;9(1):66-72.
There is some evidence that phytostrogen plays an important role in bone metabolism in postmenopausal women. In this study, we investigated the phytoestrogen intake levels and the relation between dietary...
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