- Basophil Activation Test for Chronic Urticaria
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Chirumbolo S
- KMID: 2373584
- Ann Lab Med.
- 2016 Sep;36(5):499-500.
- doi: 10.3343/alm.2016.36.5.499
No abstract available. -
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- New PDEs Inhibitors for Erectile Dysfunction
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Choi HK
- KMID: 2183138
- J Korean Med Assoc.
- 2003 Nov;46(11):1050-1056.
- doi: 10.5124/jkma.2003.46.11.1050
Phosphodiesterases (PDEs) are functionally diverse enzymes with wide organ and tissue distributions. Of these enzymes, PDE5 has received particular attention largely because of the introduction and widespread use of the... -
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- Quantitative expression analysis of two NAGPA isoforms in multiple human cDNA tissue panels
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Kang C
- KMID: 1498923
- J Biomed Res.
- 2013 Jun;14(2):65-70.
Uncovering enzyme (UCE), encoded by the human NAGPA, is a trans-Golgi enzyme that adds the mannose-6-phosphate recognition tag on lysosomal enzymes destined for the lysosome. Mutations in NAGPA are known... -
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- Increased Level of Basophil CD203c Expression Predicts Severe Chronic Urticaria
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Ye YM, Yang EM, Yoo HS, Shin YS, Kim SH, Park HS
- KMID: 1796913
- J Korean Med Sci.
- 2014 Jan;29(1):43-47.
- doi: 10.3346/jkms.2014.29.1.43
Increased FcepsilonR1alpha expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c... -
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- ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
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Jeong DJ, Lee DG, Kim HJ, Cho EH, Kim SW
- KMID: 2029890
- Korean Diabetes J.
- 2010 Oct;34(5):320-326.
- doi: 10.4093/kdj.2010.34.5.320
BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and... -
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- Caffeine causes glycerophosphorylcholine accumulation through ryanodine-inhibitable increase of cellular calcium and activation of phospholipase A2 in cultured MDCK cells
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Kim DK, Jung KY
- KMID: 1109298
- Exp Mol Med.
- 1998 Sep;30(3):151-158.
Glycerophosphrylocholine (GPC) is a renal medullary compatible organic osmolyte that is derived from choline via phosphatidylcholine, which is catalyzed in part by phospholipase A2 (PLA2) and its degradation by GPC: choline phosphodiesterase (GPC:... -
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- Time-Phasic Development of Nitrate Tolerance According to the Hemodynamic Responses and the Expression of Phosphodiesterase 1A1
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Kim D, Hong BK, Choi EY, Kwon HM, Kim DY, Kwon SW, Lee SJ, Park JK, Yoon YW, Kim HS
- KMID: 2093918
- Korean Circ J.
- 2005 Jan;35(1):94-99.
- doi: 10.4070/kcj.2005.35.1.94
BACKGROUND AND OBJECTIVES: Time-phasic development of nitrate tolerance in cardiovascular diseases is very important because it can contribute to the advent of blunted vasodilation or rebound ischemia even during continuous... -
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- Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis
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Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK
- KMID: 2165561
- Exp Neurobiol.
- 2015 Sep;24(3):246-251.
- doi: 10.5607/en.2015.24.3.246
Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized... -
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- Studies on Intracellular Signal Transduction Pathway Involved in Human and Rabbit's Corpus Cavernosal Smooth Muscle Relaxation
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Kim SW, Park KJ, Park DW, Jeong IG, Son HC, Paick JS
- KMID: 2298657
- Korean J Androl.
- 2001 Aug;19(2):99-107.
PURPOSE: Nitric oxide (NO) and phosphodiesterases (PDEs) play key roles in mediating relaxation of corpus cavernosal smooth muscle by increasing intracellular cGMP level. Here, we investigated effects of NO-donor (sodium... -
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- Impact of ENPP1 K121Q on Change of Insulin Resistance after Web-Based Intervention in Korean Men with Diabetes and Impaired Fasting Glucose
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Kang JY, Sung SH, Lee YJ, Choi TI, Choi SJ
- KMID: 2129624
- J Korean Med Sci.
- 2014 Oct;29(10):1353-1359.
- doi: 10.3346/jkms.2014.29.10.1353
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may... -
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- Effect of Angiotensin II on Gene Expression of cGMP-Specific Phosphodiesterases
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Kim D, Hong BK, Kwon HM, Kim DY, Cho YH, Yoon SJ, Kim HS, Yan C
- KMID: 2029615
- Korean Circ J.
- 2003 Feb;33(2):130-138.
- doi: 10.4070/kcj.2003.33.2.130
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) opposes the actions of nitric oxide (NO). A balance between Ang II and NO is critical for the maintenance of normal vessel tone,... -
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- The Effect of Local Delivery of IBMX on the Neointimal Proliferation in Rat Carotid Balloon Injury Model
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Lee BK, Yoon J, Lee HH, Kim JY, Ko JY, Lee SH, Yoo BS, Hwang SO, Choe KH
- KMID: 2093723
- Korean Circ J.
- 1999 Oct;29(10):1097-1104.
- doi: 10.4070/kcj.1999.29.10.1097
BACKGROUND: Hyperplastic neointima is one of the major mechanisms of restenosis following balloon angioplasty in selected patients with symptomatic angina pectoris. Elevation of cellular cyclic nucleotide levels such as cAMP... -
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- Effect of Benfotiamine on the Expression of Phosphodiesterase Type 5 and Its Isoforms in Type 2 Diabetic Rat Kidneys
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Shim JB, Yang DY, Han YK, Lee SJ, Kim HJ, Jung HC, Kim SY, Kim HY, Lee YJ
- KMID: 2298740
- Korean J Androl.
- 2010 Aug;28(2):93-99.
PURPOSE: The phosphodiesterases (PDEs) are critical components in the cyclic AMP/protein kinase A and the cyclic GMP/phosphokinase G signaling pathways. The cAMP and cGMP pathways are regulated by activation and... -
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- Expression and regulation of Enpp2 in rat uterus during the estrous cycle
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Ahn HJ, Yang H, An BS, Choi KC, Jeung EB
- KMID: 1365022
- J Vet Sci.
- 2011 Dec;12(4):379-385.
- doi: 10.4142/jvs.2011.12.4.379
Ectonucleotide pyrophosphatase/phosphodiestrase 2 (Enpp2) isolated from the supernatant of human melanoma cells is a lysophospholipase D that transforms lysophosphatidylcholine into lysophospatidic acid. Although multiple analyses have investigated the function of... -
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- The K121Q Polymorphism in ENPP1 (PC-1) Is Not Associated with Type 2 Diabetes or Obesity in Korean Male Workers
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Seo HJ, Kim SG, Kwon OJ
- KMID: 1786885
- J Korean Med Sci.
- 2008 Jun;23(3):459-464.
- doi: 10.3346/jkms.2008.23.3.459
Type 2 diabetes is characterized by insulin resistance, and ENPP1 plays an important role in insulin resistance. We investigated the association of the ENPP1 K121Q polymorphism with both diabetes and... -
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