- The renoprotective effects of pentoxifylline: beyond its role in diabetic nephropathy
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Kapoor S
- KMID: 1776463
- Korean J Intern Med.
- 2013 May;28(3):374-376.
- doi: 10.3904/kjim.2013.28.3.374
No abstract available. -
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- Comparison of the Efficacy, Safety and Patient Preference of the Phosphodiesterase Type 5 Inhibitors for the Patients with Erectile Dysfunction
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Yoo C, Park J, Kim W, Hong B, Hong J, Ahn TY
- KMID: 2139764
- Korean J Urol.
- 2007 Feb;48(2):219-225.
- doi: 10.4111/kju.2007.48.2.219
PURPOSE: To compare the clinical efficacy and safety of three phosphodiesterase type 5 (PDE5) inhibitors in the treatment of mele erectile dysfunction according to patient preference. MATERIALS AND METHODS: Between... -
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- Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow
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Kim JW, Lee JB, Lee SH
- KMID: 2459522
- Korean J Ophthalmol.
- 2019 Oct;33(5):414-421.
- doi: 10.3341/kjo.2019.0057
PURPOSE: Phosphodiesterase (PDE) inhibitors increase matrix metalloproteinase (MMP) production by inhibiting re-uptake of adenosine and may potentiate nitric oxide (NO) activity. This study was performed to investigate the effects and... -
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- Effect of Phosphodiesterase Inhibitor on Diabetic Nephropathy
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Kang SW
- KMID: 1776540
- Korean J Intern Med.
- 2012 Jun;27(2):151-153.
- doi: 10.3904/kjim.2012.27.2.151
No abstract available. -
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- The Analysis of Preference for Three PDE-5 Inhibitors
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Yoon CJ, Lee SH, Moon KH, Yoo ES, Park JS, Lee KS, Shin HC, Lee YW
- KMID: 2226639
- Korean J Androl.
- 2005 Dec;23(3):116-121.
PURPOSE: To evaluate the preference factors for the treatment of erectile dysfunction (ED) with three different kinds of PDE-5 inhibitors. MATERIALS AND METHODS: This prospective, open-label study recruited 140 patients... -
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- Nitric oxide and pulmonary hypertension
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Sim JY
- KMID: 2031771
- Korean J Anesthesiol.
- 2010 Jan;58(1):4-14.
- doi: 10.4097/kjae.2010.58.1.4
Pulmonary hypertension is a serious complication of a number of lung and heart diseases that is characterized by peripheral vascular structural remodeling and loss of vascular tone. Nitric oxide can... -
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- Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
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Cho ES, Yu JH, Kim MS, Yim M
- KMID: 2158125
- Yonsei Med J.
- 2005 Feb;46(1):149-154.
- doi: 10.3349/ymj.2005.46.1.149
Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of... -
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- Effect of DA-8159, a Selective Phosphodiesterase Type 5 Inhibitor, on Electroretinogram and Retinal Histology in Rabbits
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Cho HK, Kang KK, Ahn GJ, Shim HJ, Kim WB
- KMID: 2157690
- J Korean Med Sci.
- 2004 Aug;19(4):586-590.
- doi: 10.3346/jkms.2004.19.4.586
DA-8159, a selective inhibitor of phosphodiesterase type 5, was developed as a new drug for erectile dysfunction. The effect of DA-8159 on the electroretinogram (ERG) and the retinal histopathology were... -
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- Hydroxyl radical-mediated commitment of HL-60 cells to differentiation: Modulation of differentiation process by phosphodiesterase inhibitors
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Cho JY, Ahn WS, Cha SH, Lee KH, Kim WI, Chung MH
- KMID: 1849845
- Korean J Physiol Pharmacol.
- 1998 Jun;2(3):369-376.
Ms report shows that hydroxyl radical, generated by a Fenton reaction involving adenosine 5'-diphosphate/Fe2+ complex (5-15 micrometer) and H2O2 (2 micrometer), induced differentiation of HL-60 cells in a dose- and time-dependent manner. This... -
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- A Case Report of Treatment of Renal Insufficiency and Toxic Hepatitis Caused By Amlodipine Intoxication
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Park JH, Kim SJ, Cho NS
- KMID: 1898817
- J Korean Soc Emerg Med.
- 2006 Jun;17(3):273-276.
Amlodipine is widely used in the management of diverse cardiovascular conditions, including hypertension, arrhythmias, angina and myocardiac infarction. When overdosed, the drugs cause hypotension, bradycardia, cardiogenic shock, mental change, generalized... -
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- Recent medical therapy for psoriasis
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Youn SW
- KMID: 2441069
- J Korean Med Assoc.
- 2019 Mar;62(3):176-180.
- doi: 10.5124/jkma.2019.62.3.176
Psoriasis is a chronic inflammatory disease. Medical therapy is the mainstay of the management of psoriasis, and the main target of psoriasis treatment is immunological dysregulation. Cyclosporine and methotrexate, the... -
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- Pharmacologic Management of the Cardio-renal Syndrome
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Kim CS
- KMID: 2168396
- Electrolyte Blood Press.
- 2013 Jun;11(1):17-23.
- doi: 10.5049/EBP.2013.11.1.17
Cardio-renal syndromes are disorders of the heart and kidney wherein acute or long-term dysfunction in one organ may induce acute or long-term dysfunction of the other. Because of this complex... -
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- A Case Report of Effective Use of an Intra-aortic Balloon Pump in Calcium Channel Blocker Intoxication
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Hyun SY, Jung TG, Lee JG, Kim JJ, Kim JK, Lim YS, Yang HJ, Lee SK
- KMID: 2193772
- J Korean Soc Emerg Med.
- 2005 Feb;16(1):210-213.
When used appropriately, calcium channel blockers are safe and efficacious. When overdose, however, these agents have the potential for serious morbidity which can lead to profound bradycardia and hypotension. The... -
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- Current Status and Clinical Studies of Oriental Herbs in Sexual Medicine in Korea
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Shin YS, Zhao C, Zhang LT, Park JK
- KMID: 2032825
- World J Mens Health.
- 2015 Aug;33(2):62-72.
- doi: 10.5534/wjmh.2015.33.2.62
Erectile dysfunction (ED) is one of the most common diseases among aging men. Although previous studies have shown that type 5 phosphodiesterase inhibitors (PDE5-Is) are very effective for the treatment... -
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- The Effect of Caffeine, Theophylline and Adenosine on the Colonic Transit Time of Guinea Pigs
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Moon JT, Choi EJ, Kim YG, Kim HS, Park HJ
- KMID: 2307487
- Korean J Neurogastroenterol Motil.
- 2006 Dec;12(2):117-121.
BACKGROUND/AIMS: Caffeine and theophylline are adenosine receptor antagonists and they are also non-specific phosphodiesterase inhibitors. We aimed to estimate the effects of caffeine and theophylline on the colonic activity of... -
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- Time-dependent Changes in Erectile Function and Responsiveness to Phosphodiesterase Type 5 Inhibitor in Streptozotocin-induced Diabetic Rats
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Cho SY, Kim SW
- KMID: 2298739
- Korean J Androl.
- 2010 Aug;28(2):85-92.
PURPOSE: The aim of this study was to investigate time-dependent changes in erectile function and responsiveness to type 5 phosphodiesterase (PDE5) inhibitor in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Seventy-five 8-week-old... -
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- The Antiallodynic Effects of Intrathecal Zaprinast in Rats with Chronic Constriction Injury of the Sciatic Nerve
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Lee JD, Jun IG, Choi YS, Im SH, Park JY
- KMID: 1767811
- Korean J Pain.
- 2009 Apr;22(1):16-20.
- doi: 10.3344/kjp.2009.22.1.16
BACKGROUND: Zaprinast is an inhibitor of phosphodiesterase 5, 6 and 9. Phosphodiesterase inhibitors could produce anti-nociceptive effects by promoting the accumulation of cGMP. We hypothesized that intrathecal zaprinast could attenuate... -
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- Effects of Mirodenafil, a Phosphodiesterase-5 Inhibitor, on Female Rat Bladder in a Partial Bladder Outlet Obstruction Model: Physiological and Immunohistochemical Aspects
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Kang JY, Kim EK, Kim KM
- KMID: 2061517
- Korean J Urol.
- 2013 May;54(5):339-344.
- doi: 10.4111/kju.2013.54.5.339
PURPOSE: We investigated the effects of mirodenafil, a phosphodiesterase-5 inhibitor developed in South Korea, on the female rat bladder in a partial bladder outlet obstruction (BOO) model. MATERIALS AND METHODS: Thirty-six... -
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- Altitude Stress During Participation of Medical Congress
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Kim SB, Kim JS, Kim SJ, Cho SH, Suh DC
- KMID: 2350683
- Neurointervention.
- 2016 Sep;11(2):73-77.
- doi: 10.5469/neuroint.2016.11.2.73
Medical congresses often held in highlands. We reviewed several medical issues associated with altitude stress especially while physicians have participated medical congress held in high altitude. Altitude stress, also known... -
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- Can the PDE5 Inhibitor Replace Intracavernosal Injection as a Method for Inducing a Penile Erection during the Evaluation of Erectile Dysfunction Using Penile Duplex Ultrasonography?
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Ryu IW, Yoon H, Shim BS, Park YY, Chung WS
- KMID: 2311969
- Korean J Urol.
- 2008 Jul;49(7):641-646.
PURPOSE: To clarify whether vardenafil can be used as a substitute for intracavernosal injection as a method of induction of penile erection, we compared the outcome of penile duplex Doppler... -
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