J Korean Soc Emerg Med.  2006 Jun;17(3):273-276.

A Case Report of Treatment of Renal Insufficiency and Toxic Hepatitis Caused By Amlodipine Intoxication

• Park JH
• Kim SJ
• Cho NS

Abstract

Amlodipine is widely used in the management of diverse cardiovascular conditions, including hypertension, arrhythmias, angina and myocardiac infarction. When overdosed, the drugs cause hypotension, bradycardia, cardiogenic shock, mental change, generalized seizure, hyperglycemia with metabolic acidosis, rarely toxic hepatitis and renal insufficiency. Initial management of critically ill patients consists of supporting airway, breathing and circulation. Maintenance of adequate circulation in poisoned patients often requires a multitude of simultaneous therapies including intravenous fluids, vasopressors, calcium, glucagon, phosphodiesterase inhibitors and high-dose insulin. We report a case of successful treatment of renal insufficiency and toxic hepatitis caused by calcium channel blocker intoxication.

Keyword

Amlodipine; Renal Insufficiency; Hepatitis; Toxic

MeSH Terms

Acidosis
Amlodipine*
Arrhythmias, Cardiac
Bradycardia
Calcium
Calcium Channels
Critical Illness
Drug-Induced Liver Injury*
Glucagon
Hepatitis
Humans
Hyperglycemia
Hypertension
Hypotension
Infarction
Insulin
Phosphodiesterase Inhibitors
Renal Insufficiency*
Respiration
Seizures
Shock, Cardiogenic
Amlodipine
Calcium
Calcium Channels
Glucagon
Insulin
Phosphodiesterase Inhibitors