- Effects of Caffeic Acid, Myristicin and Rosemarinic Acid on the Gene Expression and Production of Airway MUC5AC Mucin
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Lee HJ, Lee KR, Hong JH, Lee CJ
- KMID: 2366696
- Nat Prod Sci.
- 2016 Dec;22(4):275-281.
- doi: 10.20307/nps.2016.22.4.275
Perilla frutescens was empirically used for controlling airway inflammatory diseases in folk medicine. We investigated whether caffeic acid, myristicin and rosemarinic acid derived from Perilla frutescens significantly affect the gene... -
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- Inhibition of Proinflammatory Cytokine Generation in Lung Inflammation by the Leaves of Perilla frutescens and Its Constituents
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Lim HJ, Woo KW, Lee KR, Lee SK, Kim HP
- KMID: 2048332
- Biomol Ther.
- 2014 Jan;22(1):62-67.
This study was designed to find some potential natural products and/or constituents inhibiting proinflammatory cytokine generation in lung inflammation, since cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)... -
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- The Neuro-Protective Effect of the Methanolic Extract of Perilla frutescens var. japonica and Rosmarinic Acid against H2O2-Induced Oxidative Stress in C6 Glial Cells
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Lee AY, Wu TT, Hwang BR, Lee J, Lee MH, Lee S, Cho EJ
- KMID: 2164227
- Biomol Ther.
- 2016 May;24(3):338-345.
- doi: 10.4062/biomolther.2015.135
Neurodegenerative diseases are often associated with oxidative damage in neuronal cells. This study was conducted to investigate the neuro-protective effect of methanolic (MeOH) extract of Perilla frutescens var. japonica and... -
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- Anti-hyperglycemic effects and signaling mechanism of Perilla frutescens sprout extract
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Kim DH, Kim SJ, Yu KY, Jeong SI, Kim SY
- KMID: 2429015
- Nutr Res Pract.
- 2018 Feb;12(1):20-28.
- doi: 10.4162/nrp.2018.12.1.20
BACKGROUND/OBJECTIVES: Perilla frutescens (L.) Britton var. (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced β-cell damage.... -
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- Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells
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Kwak Y, Ju J
- KMID: 2313803
- Nutr Res Pract.
- 2015 Feb;9(1):11-16.
- doi: 10.4162/nrp.2015.9.1.11
BACKGROUND/OBJECTIVES: Perilla frutescens Britton leaves are a commonly consumed vegetable in different Asian countries including Korea. Cancer is a major cause of human death worldwide. The aim of the current... -
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- Perilla frutescens var. japonica and rosmarinic acid improve amyloid-β25-35 induced impairment of cognition and memory function
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Lee AY, Hwang BR, Lee MH, Lee S, Cho EJ
- KMID: 2342129
- Nutr Res Pract.
- 2016 Jun;10(3):274-281.
- doi: 10.4162/nrp.2016.10.3.274
BACKGROUND/OBJECTIVES: The accumulation of amyloid-β (Aβ) in the brain is a hallmark of Alzheimer's disease (AD) and plays a key role in cognitive dysfunction. Perilla frutescens var. japonica extract (PFE)... -
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- Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway
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Jin CH, So YK, Han SN, Kim JB
- KMID: 2351675
- Biomol Ther.
- 2016 Sep;24(5):510-516.
- doi: 10.4062/biomolther.2015.194
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK... -
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- Rosmarinic Acid Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep through the Activation of GABA(A)-ergic Systems
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Kwon YO, Hong JT, Oh KW
- KMID: 2375029
- Biomol Ther.
- 2017 Mar;25(2):105-111.
- doi: 10.4062/biomolther.2016.035
It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like... -
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