- Clinical Significance of PTEN Expression in Bladder Cancer
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Shin DJ, Chung MJ, Kim HJ
- KMID: 2292311
- Korean J Urol.
- 2001 Jun;42(6):594-597.
PURPOSE: PTEN (phosphatase and tensin homolog) is a tumor suppressor gene located on the chromosome 10q23. PTEN plays a role in inducing cell cycle arrest and apoptosis. We determined the... -
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- Expression Patterns of PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in Osteosarcoma
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Moon SH, Lee SH, Kim HS, Kwon JW, Kim CH, Chung TW, Ryu TU, Lee HS, Hwang CS, Lee HK
- KMID: 2399018
- J Korean Orthop Assoc.
- 2003 Feb;38(1):39-46.
PURPOSE: To characterize PTEN gene alterations and their expressions during the development of osteosarcoma. MATERIALS AND METHODS: We studied the pattern of deletion, mutation and expression of PTEN in normal... -
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- Correlation between the Expression Reduction of Insulin-like Growth Factor Binding Protein (IGFBP)-3 and PTEN and the Clinicopathological Parameters in Breast Cancer
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Jung SH, Youn HJ, Kim MS, Kim SY, Hwang PH, Lee DY
- KMID: 2211976
- J Korean Surg Soc.
- 2010 Aug;79(2):79-85.
- doi: 10.4174/jkss.2010.79.2.79
PURPOSE: Insulin-like growth factor binding protein (IGFBP-3) and phosphatase and tensin homolog (PTEN) are tumor-suppressor genes that may be involved in breast tumorigenesis. However, the roles of these genes in... -
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- Mutational and Loss of Heterozygosity Analysis of the p53 and PTEN Tumor Suppressor Genes in Breast Carcinoma
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Suh KS, Lee YH, Na SY, Park MI, Kim HS, Lee SK
- KMID: 1598229
- Korean J Pathol.
- 2005 Oct;39(5):313-319.
BACKGROUND: Although the genetic determinants of most sporadic breast cancers remain unknown, the understanding of the molecular and genetic events that contribute to breast carcinogenesis has been significantly advanced. We... -
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- Clinical Analysis of PTEN, p53 and Her-2/neu Expressions in Thyroid Cancers
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Kim JS, Bae JS, Kim KH, Ahn CH, Oh SJ, Jeon HM, Lim KW, Chun CS
- KMID: 1804435
- Cancer Res Treat.
- 2001 Oct;33(5):433-437.
PURPOSE: The dual-specificity phosphatase PTEN/ MMAC1/TEP1 has recently been identified as the tumor suppressor gene most frequently mutated and/or deleted in human tumors. However, PTEN mutations have rarely been detected... -
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- Cowden Disease: Case Report and Review of the Literature
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Son JH, Chung BY, Jung MJ, Choi YW, Kim HO, Park CW
- KMID: 2444866
- Ann Dermatol.
- 2019 Jun;31(3):325-330.
- doi: 10.5021/ad.2019.31.3.325
Cowden's disease is a rare autosomal dominant, multiple hamartoma syndrome with characteristic mucocutaneous lesions. It is associated with abnormalities of the breast, thyroid, and gastrointestinal tract; and is characterized by... -
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- Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN
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Liu T, Liu S, Xu Y, Shu R, Wang F, Chen C, Zeng Y, Luo H
- KMID: 2424811
- Cancer Res Treat.
- 2018 Oct;50(4):1396-1417.
- doi: 10.4143/crt.2017.537
PURPOSE: This study aimed to probe into the associations among circular RNA ZFR (circ-ZFR), miR-130a/miR-107, and PTEN, and to investigate the regulatory mechanism of circ-ZFR–miR-130a/miR-107–PTEN axis in gastric cancer (GC). MATERIALS... -
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- Cowden Syndrome Presenting as Breast Cancer: Imaging and Clinical Features
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Seo M, Cho N, Ahn HS, Moon HG
- KMID: 1734943
- Korean J Radiol.
- 2014 Oct;15(5):586-590.
- doi: 10.3348/kjr.2014.15.5.586
Cowden syndrome is an uncommon, autosomal dominant disease which is characterized by multiple hamartomas of the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. The diagnosis of Cowden syndrome... -
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- p16INK4a, PTEN, E-cadherin, Bcl-2 and Ki-67 Expression in Prostate Cancer: Its Relationship with the Metastatic Potential and Known Prognostic Factors
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Park SJ, Sung WJ, Kim MJ
- KMID: 2277536
- Korean J Pathol.
- 2010 Dec;44(6):597-604.
BACKGROUND: At present, adequate prognostic markers for prostate cancer progression are still lacking, in spite of intensive investigation. Accordingly, our study examined the relationship between expression of candidate biomarkers and... -
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- Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells
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Lee SH, Lee YP, Kim SY, Jeong MS, Lee MJ, Kang HW, Jeong HJ, Kim DW, Sohn EJ, Jang SH, Kim YH, Kwon HJ, Cho SW, Park J, Eum WS, Choi SY
- KMID: 1072943
- Exp Mol Med.
- 2008 Dec;40(6):629-638.
- doi: 10.3858/emm.2008.40.6.629
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor. Although it is well known to have various physiological roles in cancer, its inhibitory effect on inflammation... -
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- TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells
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Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS
- KMID: 1103688
- Exp Mol Med.
- 2007 Feb;39(1):121-127.
TNF-alpha plays a variety of biological functions such as apoptosis, inflammation and immunity. PTEN also has various cellular function including cell growth, proliferation, migration and differentiation. Thus, possible relationships between... -
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- Correlation of Immunohistochemical Markers and BRAF Mutation Status with Histological Variants of Papillary Thyroid Carcinoma in the Korean Population
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Min HS, Lee C, Jung KC
- KMID: 1786960
- J Korean Med Sci.
- 2013 Apr;28(4):534-541.
- doi: 10.3346/jkms.2013.28.4.534
Several pathologic characteristics are associated with an adverse clinical outcome in papillary thyroid carcinoma (PTC), including the histological variant. This study aimed to investigate immunohistochemical expression and BRAF mutation status... -
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- Expression of PTEN and Its Correlation with Angiogenesis in Gastric Carcinoma
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Park GS, Joo YE, Kim HS, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 935211
- Korean J Gastroenterol.
- 2005 Sep;46(3):196-203.
BACKGROUND/AIMS: Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a recently clarified tumor suppressor gene located in 10q23.3. Alterations of this gene are associated with tumor progression and... -
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- PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells
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Hwang PH, Kim SY, Lee JC, Kim SJ, Yi HK, Lee DY
- KMID: 1089448
- Exp Mol Med.
- 2005 Oct;37(5):391-398.
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. Its major function is likely to be the phosphatase activity that regulates the... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Inhibitory Effect of Melanoma Differentiation Associated Gene-7/Interleukin-24 on Invasion In Vitro of Human Melanoma Cancer Cells
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Lin BW, Jiao ZL, Fan JF, Peng L, Li L, Zhao ZG, Ding XY, Li HJ
- KMID: 2158029
- J Korean Med Sci.
- 2013 Jun;28(6):833-839.
- doi: 10.3346/jkms.2013.28.6.833
The acquisition of metastasis potential is a critical point for malignant tumors. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a potential tumor suppress gene and frequently down-regulated in malignant tumors. It... -
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