- Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells
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Jeong EH, Choi HS, Lee TG, Kim HR, Kim CH
- KMID: 2319806
- Tuberc Respir Dis.
- 2012 Apr;72(4):343-351.
BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit this pathway are currently under development for... -
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- Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by beta-adrenoceptor
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Endale M, Song JC, Rhee MH, Liu KH, Kim TK, Kwon JG, Park KS, Chung KM, Kim TW
- KMID: 1444964
- Lab Anim Res.
- 2011 Dec;27(4):317-325.
- doi: 10.5625/lar.2011.27.4.317
Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are... -
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- Inhibition of Hypoxic Pulmonary Vasoconstriction of Rats by Carbon Monoxide
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Yoo HY, Park SJ, Bahk JH, Kim SJ
- KMID: 2157842
- J Korean Med Sci.
- 2010 Oct;25(10):1411-1417.
- doi: 10.3346/jkms.2010.25.10.1411
Hypoxic pulmonary vasoconstriction (HPV), a unique response of pulmonary circulation, is critical to prevent hypoxemia under local hypoventilation. Hypoxic inhibition of K+ channel is known as an important O2-sensing mechanism... -
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- Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser
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Hotta Y, Ieda N, Fukamoto A, Kataoka T, Kawade Y, Maeda Y, Nakagawa H, Kimura K
- KMID: 2426497
- Investig Clin Urol.
- 2016 May;57(3):215-220.
- doi: 10.4111/icu.2016.57.3.215
PURPOSE: To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, light-controllable nitric oxide (NO) releaser. MATERIALS AND METHODS: Fifteen-week-old male Wistar-ST rats were... -
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- Cinnamyl alcohol attenuates vasoconstriction by activation of K+ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase
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Kang YH, Yang IJ, Morgan KG, Shin HM
- KMID: 1402319
- Exp Mol Med.
- 2012 Dec;44(12):749-755.
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate the vasodilatory effect and the mechanism of... -
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