- Trichostatin A-mediated upregulation of p21
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Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM
- KMID: 1094662
- Exp Mol Med.
- 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about... -
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- Eupatilin Ameliorates Collagen Induced Arthritis
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Kim J, Kim Y, Yi H, Jung H, Rim YA, Park N, Jung SM, Park SH, Ju JH
- KMID: 2133298
- J Korean Med Sci.
- 2015 Mar;30(3):233-239.
- doi: 10.3346/jkms.2015.30.3.233
Eupatilin is the main active component of DA-9601, an extract from Artemisia. Recently, eupatilin was reported to have anti-inflammatory properties. We investigated the anti-arthritic effect of eupatilin in a murine... -
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- Deflazacort Increases Osteoclast Formation in Mouse Bone Marrow Culture and the Ratio of RANKL/OPG mRNA Expression in Marrow Stromal Cells
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Chung H, Kang YS, Hwang CS, Moon IK, Yim CH, Choi KH, Han KO, Jang HC, Yoon HK, Han IK
- KMID: 648360
- J Korean Med Sci.
- 2001 Dec;16(6):769-773.
- doi: 10.3346/jkms.2001.16.6.769
Information on precise effects of deflazacort on bone cell function, especially osteoclasts, is quite limited. Therefore, the present study was undertaken to test effects of deflazacort on osteoclast-like cell formation... -
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- B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis
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Choi Y, Kim JJ
- KMID: 1093611
- Exp Mol Med.
- 2003 Oct;35(5):385-392.
Host immune response has been considered as an important disease-modifying factor of periodontitis, however, which immune cell(s) or factor(s) are involved in the destruction of periodontium remains unclear. Previously, we... -
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- Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB
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Kyung TW, Lee JE, Shin HH, Choi HS
- KMID: 1103588
- Exp Mol Med.
- 2008 Feb;40(1):52-58.
- doi: 10.3858/emm.2008.40.1.52
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its... -
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- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
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Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
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- Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL
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Woo KM, Kim HM, Ko JS
- KMID: 755205
- Exp Mol Med.
- 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast... -
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- Regulation of matrix metalloproteinase-9 protein expression by 1alpha,25-(OH)2D3 during osteoclast differentiation
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Gu JH, Tong XS, Chen GH, Liu XZ, Bian JC, Yuan Y, Liu ZP
- KMID: 1737619
- J Vet Sci.
- 2014 Mar;15(1):133-140.
- doi: 10.4142/jvs.2014.15.1.133
To investigate 1alpha,25-(OH)2D3 regulation of matrix metalloproteinase-9 (MMP-9) protein expression during osteoclast formation and differentiation, receptor activator of nuclear factor kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) were administered... -
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- Involvement of the Ca2+ signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation
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Fu Y, Gu J, Wang Y, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2164523
- J Vet Sci.
- 2015 Jun;16(2):151-156.
- doi: 10.4142/jvs.2015.16.2.151
The purpose of this study was to determine whether the Ca2+ signaling pathway is involved in the ability of osteoprotegerin (OPG) to inhibit osteoclast differentiation and maturation. RAW264.7 cells were... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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- Serum amyloid A inhibits RANKL-induced osteoclast formation
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Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS
- KMID: 2359881
- Exp Mol Med.
- 2015 Nov;47(11):e194.
- doi: 10.1038/emm.2015.83
When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator... -
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- High extracellular Ca2+ alone stimulates osteoclast formation but inhibits in the presence of other osteoclastogenic factors
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Shin MM, Kim YH, Kim SN, Kim GS, Baek JH
- KMID: 1094697
- Exp Mol Med.
- 2003 Jun;35(3):167-174.
High ambient Ca2+ at bone resorption sites have been implicated to play an important role in the regulation of bone remodeling. The present study was performed to clarify the mode... -
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