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Effect of Suvorexant on Nocturnal Delirium in Elderly Patients with Alzheimer's Disease: A Case-series Study

Hanazawa T, Kamijo Y

Suvorexant, an orexin receptor antagonist used for insomnia, has been shown to have a preventive effect on delirium in a randomized placebo-controlled trial. However, its effectiveness in the management of...
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Recent Updates on Narcolepsy and Hypersomnia

Hong S

Narcolepsy is a chronic neurological sleep disorder caused by hypocretin neuron loss, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and intrusions of aspects of rapid eye movement sleep in...
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Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats

Kooshki R, Abbasnejad M, Esmaeili Mahani S, Raoof M, Moeini Aghtaei MM, Dabiri S

BACKGROUND: The trigeminal nucleus caudalis (Vc) is a primary central site for trigeminal transmitting. Noxious stimulation of the trigeminal nociceptors alters the central synaptic releases and neural expression of some...
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Narcolepsy in Children

Seo WS

  • KMID: 2317500
  • Sleep Med Psychophysiol.
  • 2011 Jun;18(1):17-22.
Childhood narcolepsy is one of the underdiagnosed diseases even the first symptoms often appear in childhood. Making diagnosis through history taking is not always easy because the symptoms of childhood...
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Narcolepsy: Clinical Feature, Diagnosis and Treatment

Shin HB

  • KMID: 2317492
  • Sleep Med Psychophysiol.
  • 2010 Dec;17(2):63-68.
Narcolepsy is a central neurologic system disease. It begins early in life with disabling symptoms including excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucination and nocturnal sleep fragmentation. Patient with...
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Late-Onset Narcolepsy with Cataplexy Unresponsive to Intravenous High-Dose Immunoglobulin Treatment

Cho JW, Jung NY, Bae JW, Kim DJ, Lee JH, Kanbayashi T

  • KMID: 2343436
  • J Korean Neurol Assoc.
  • 2012 Feb;30(1):57-59.
Narcolepsy with cataplexy (NC) is associated with hypocretin deficiency, and is thought to be an autoimmunity condition. The mean age at onset is estimated to be in the early 20s....
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The Effect of Sleep Loss on Energy and Metabolism

Kang SG

  • KMID: 2317512
  • Sleep Med Psychophysiol.
  • 2012 Jun;19(1):5-10.
The release of hormones and the metabolism of human body are controlled by the circadian rhythm related to sleep-wake cycle. Growth hormone, prolactin, thyroid stimulating hormone, cortisol, glucose, and insulin-secretion...
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Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells

Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK

The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1...
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How Leptin Controls the Drive to Eat

Patterson , Myers MG

  • KMID: 2271158
  • Korean J Obes.
  • 2015 Jun;24(2):69-77.
A complex set of brain based systems modulate feeding to maintain constant body weight. The adipose derived-hormone, leptin, plays a crucial role in this control by acting on diverse leptin...
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CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis

Cho CH, Lee HJ, Woo HG, Choi JH, Greenwood , Kelsoe JR

Although bipolar disorder is highly heritable, the identification of specific genetic variations is limited because of the complex traits underlying the disorder. We performed a genome-wide association study of bipolar...
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Abnormal Cerebral Glucose Metabolism in Patients with Narcolepsy

Joo EY, Tae WS, Kim JH, Han SJ, Cho YW, Kim L, Yun CH, Kim MH, Kim BT, Hong SB

  • KMID: 2343082
  • J Korean Neurol Assoc.
  • 2004 Aug;22(4):340-344.
BACKGROUND: The purpose of this study was to investigate the differences of cerebral glucose metabolism between narcoleptic patients and normal controls. METHODS: We enrolled 24 patients with narcolepsy who underwent...
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Comparison of Narcolepsy with Cataplexy and without Cataplexy: Clinical Variables, HLA-DQB1*0602, and Hypocretin

Jeong JH, Hong SC, Shin YK, Han JH, Lee SP

  • KMID: 2341266
  • J Korean Neuropsychiatr Assoc.
  • 2007 Jan;46(1):50-57.
OBJECTIVES: Narcolepsy is a sleep disorder, characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic hallucination. Among these symptoms, cataplexy is one of the most pathognomonic symptoms in narcolepsy....
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Excessive Daytime Sleepiness Case Confounding with Thyrotoxicosis

Chung JK, Kim EJ

  • KMID: 2317504
  • Sleep Med Psychophysiol.
  • 2011 Jun;18(1):40-44.
Narcolepsy is a sleep disorder, which is characterized by excessive daytime sleepiness (EDS) that is typically associated with cataplexy, sleep fragmentation and other REM sleep-related phenomenon such as sleep paralysis...
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