- Effects of Co-Administration of Intrathecal Nociceptin/Orphanin FQ and Opioid Antagonists on Formalin-Induced Pain in Rats
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Lee H
- KMID: 1727895
- Yonsei Med J.
- 2013 May;54(3):763-771.
- doi: 10.3349/ymj.2013.54.3.763
PURPOSE: Nociceptin/orphanin FQ (N/OFQ) as an endogeneous hexadecapeptide is known to exert antinociceptive effects spinally. The aims of this study were to demonstrate the antinociceptive effects of i.t. N/OFQ and... -
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- Roles of Opioid Receptor Subtype in the Spinal Antinociception of Selective Cyclooxygenase 2 Inhibitor
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Choi CH, Kim WM, Lee HG, Jeong CW, Kim CM, Lee SH, Yoon MH
- KMID: 1454706
- Korean J Pain.
- 2010 Dec;23(4):236-241.
- doi: 10.3344/kjp.2010.23.4.236
BACKGROUND: Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis,... -
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- Quantitative Analysis of Secreted Catecholamines from Chromaffin Cells in Vitro and in Vivo
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Park JM, Kim SJ, Kwak KH, Jeon YH, Baek WY
- KMID: 2092037
- Korean J Anesthesiol.
- 2005 Aug;49(2):235-240.
- doi: 10.4097/kjae.2005.49.2.235
BACKGROUND: Adrenal medullary transplants into the subarachnoid space have been demonstrated to reduce pain sensitivity. This analgesia most likely results from the release of neuroactive substances, particularly catecholamines and... -
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- Dynorphin A (1-17) was Selective tomicro-Opioid Receptor in Agonist-Stimulated [35S] GTPgammaS Binding in Cortical and Thalamic Membranes of Monkey
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Lee H, Lee SA, Kang SY, Kim DY, Kim CH
- KMID: 2032239
- Korean J Anesthesiol.
- 2005 Apr;48(4):412-416.
- doi: 10.4097/kjae.2005.48.4.412
BACKGROUND: Dynorphin A (1-17) is conceived as an endogenous opioid peptide with a high degree of selectivity forkappa- opioid receptor even though it has been reported to sometimes act like... -
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- Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists
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Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH
- KMID: 2461036
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):427-448.
- doi: 10.4196/kjpp.2019.23.6.427
Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and... -
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- Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder
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Pusponegoro HD, Ismael S, Sastroasmoro S, Firmansyah A, Vandenplas Y
- KMID: 2383300
- Pediatr Gastroenterol Hepatol Nutr.
- 2015 Dec;18(4):230-237.
- doi: 10.5223/pghn.2015.18.4.230
PURPOSE: Various gastrointestinal factors may contribute to maladaptive behavior in children with autism spectrum disorders (ASD). To determine the association between maladaptive behavior in children with ASD and gastrointestinal symptoms... -
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- Pharmacotherapeutic Interventions to Maintaining Abstinence in Alcoholism
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Namkoong K
- KMID: 2184661
- J Korean Med Assoc.
- 2006 Feb;49(2):134-141.
- doi: 10.5124/jkma.2006.49.2.134
Alcoholism, a major public health problem throughout the world, causes an enormous damage to health and quality of life and undermines the well being of families and society. It is... -
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- Pharmacotherapy of Alcohol Use Disorders
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Namkoong K
- KMID: 2341041
- J Korean Neuropsychiatr Assoc.
- 2004 Nov;43(6):652-658.
Alcoholism, a major public health problem throughout the world, causes enormous damage to health and quality of life and undermines the well-being of families and society. It is associated with... -
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- The effects of kainate-induced Seizure on the Opioid Peptide Gene Expression in Rat Hippocampus
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Park KW, Park MK, Kim BJ, Ko SB, Kang YH, Lee DH
- KMID: 1957293
- J Korean Neurol Assoc.
- 1994 Dec;12(4):614-622.
In the rat hippocampal formation, the time-course and dose-response of the expression of enkephalin and dynorphin gene were examined after kainate (KA) treatment with in situ hybridization histochemistry. The KA... -
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- Effect of Adrenal Gland Transplantation on Mechanical Hyperalgesia Induced by Freund's Complete Adjuvant in Rats
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Lee C, Choi Y, Kim YI, Choi WS, Shin JW, Song JG
- KMID: 2240017
- Korean J Anesthesiol.
- 2001 Oct;41(4):484-489.
- doi: 10.4097/kjae.2001.41.4.484
BACKGROUND: The transplantation of adrenal medullary tissue into the CNS of the rat can reduce pain. This results from the release of opioid peptides and catecholamines from the... -
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- Plasma concentrations of nociceptin/orphanin FQ: comparison of levels after general and neuraxial anesthesia for arthroscopic knee surgery
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Lee H, Jeon H
- KMID: 2164869
- Korean J Anesthesiol.
- 2013 Oct;65(4):327-330.
- doi: 10.4097/kjae.2013.65.4.327
BACKGROUND: Nociceptin/orphanin FQ (N/OFQ) is an endogenous opioid heptadecapeptide. Preclinically, the pharmacologic action of N/OFQ has been characterized for the treatment of pain in non-human primates. Clinically, the pharmacologic action... -
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- Microencapsulated Bovine Adrenal Medullary Chromaffin Cells Transplanted into Rat Spinal Cord Alleviated Cold Allodynia
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Baek WY, Kim HG, Kim YM, Lim JO, Jeon YH
- KMID: 2236704
- Korean J Anesthesiol.
- 2004 Mar;46(3):354-359.
- doi: 10.4097/kjae.2004.46.3.354
BACKGROUND: The intrathecal grafting of adrenal chromaffin cells as a potential analgesic source, to delivery analgesic substances such as catecholamines and opioid peptides, is known to be effective at treating... -
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- Regulation of phosphorylated cAMP response element-binding protein, Fos-related antigen and FosB expression by dopamine agonists in rat striatum
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Choe ES, Kim JY
- KMID: 2071569
- Korean J Physiol Pharmacol.
- 2001 Aug;5(4):299-305.
Activation of D1-like dopamine receptors by psychostimulants, such as amphetamine, upregulates the expression of immediate early gene and opioid peptide gene in the striatum. The genomic changes are regulated by phosphorylated transcription factors... -
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- Cultured human chromaffin cells grafted in spinal subarachnoid space relieves allodynia in a pain rat model
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Jeon Y, Baek WY, Chung SH, Shin N, Kim HR, Lee SA
- KMID: 1780181
- Korean J Anesthesiol.
- 2011 May;60(5):357-361.
- doi: 10.4097/kjae.2011.60.5.357
BACKGROUND: Implantation of xenogenic chromaffin cells into the spinal subarachnoid space can produce analgesia in neuropathic pain models. However, transplantation of xenogeneic chromaffin cell has a potential risk of viral... -
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- Influence of GnRH Agonist and Neural Antagonists on Stress-blockade of LH and Prolactin Surges Induced by 17 beta-estradiol in Ovariectomized Rats
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Kam KY, Park YB, Cheon MS, Kang SS, Kim K, Ryu K
- KMID: 1122007
- Yonsei Med J.
- 2002 Aug;43(4):482-490.
- doi: 10.3349/ymj.2002.43.4.482
In our previous study, we demonstrated that immobilization stress blocked estrogen-induced luteinizing hormone(LH) surge possibly by inhibiting the synthesis and release of gonadotropin-releasing hormone (GnRH) at the hypothalamic level and... -
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- The Effect of Thyrotropin Releasing Hormone on somatosensory Evoked Potentials in Cats with Spinal Cord Injury
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Park CO, Lee KC, Leem JW, Paik KS
- KMID: 2068312
- J Korean Neurosurg Soc.
- 1987 Mar;16(1):255-264.
The therapeutic goal for the spinal injury has been focused on preventing the secondary ischemic changes because of the poor regeneration of human spinal cord. Naloxone, an antagonist of endogenous... -
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- Changes of beta-Endorphin in Patients with Maintenance Hemodialysis
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Lee EY, Choi KB, Yoon KI
- KMID: 2251546
- Korean J Med.
- 1998 Jul;55(1):96-103.
OBJECTIVE: beta-endorphin, most potent endogenous opioid peptide, is known to play an important role in many homeostatic systems such as the maintenance of blood pressure, regulation of body temperature and... -
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- Effects of Naloxone on Regional Cerebral Blood Flow in Experimentally Induced Intracerebral Hematoma in the Cat
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Park CK, Kang JK, Song JU, Kim DJ
- KMID: 1953205
- J Korean Neurosurg Soc.
- 1988 Jun;17(3):509-518.
In an attempt to investigate the role of endogenous opiate in the changes of regional cerebral flow(rCBF) in intracerrebral hematoma(ICH), an experimental model of ICH was induced in the cat.... -
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- Effective of Naloxone on Cerebral Blood Flow in the Acute Stage of Experimentally Induced Subarachnoid Hemorrhage in Cat
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Baik MW, Kang JK, Park CK, Kim Y, Jo TH, Ku JC, Yoon SH, Kim DS, Song JU
- KMID: 2068306
- J Korean Neurosurg Soc.
- 1987 Mar;16(1):175-188.
The immediate fall in cerebral blood flow(CBF) and the early clinical picture following subarachnoid hemorrhage(SAH) correlate well with the prognosis of most of the patients. But the cause of this... -
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