- Cholesterol conjugated spermine as a delivery modality of antisense oligonucleotide
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Im YK, Kim MS, Yoo H
- KMID: 1709609
- Int J Oral Biol.
- 2013 Dec;38(4):155-160.
The major issue in the development of nucleic acid based therapeutics is the inefficient delivery of these agents into cells. We prepared cholesterol conjugated spermine and evaluated its usefulness as... -
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- Molecular Approaches for Brain Tumor Therapy;Gene Transfer and Anti-sense Oligonucleotides
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Hong YK
- KMID: 1955357
- J Korean Neurosurg Soc.
- 1996 Sep;25(9):1815-1819.
Despite advances in neurosurgery, radiation, and chemotherapy, the prognosis of patients with malignant brain tumors still remains grim. Considerable efforts have been made to develop new therapeutic strategies for malignant... -
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- Development of Covalently Closed c-myb Antisense Oligonucleotides for Growth Inhibition of Leukemic Cells
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Moon IM, Park JG
- KMID: 2175232
- J Korean Cancer Assoc.
- 1999 Apr;31(2):348-359.
PURPOSE: Aberrant expression of the c-myb gene is often detected in transformed leukemic cells. Inhibition of c-myb expression by antisense oligos could be an effective way to abort rapid growth... -
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- The Role of NF-kappaB RelA Subunit for Tax-inhibition of p53 Transcriptional Activity in Human T-cell Lymphotrophic Virus Type 1
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Jeong SJ, Lee JD, Jeong MH
- KMID: 1963271
- J Bacteriol Virol.
- 2004 Sep;34(3):231-237.
Human T-cell lymphotrophic virus type I (HTLV-I) is a causative agent of adult T-cell leukemia (ATL). The viral transcriptional activator Tax encoded by the HTLV-I genome is thought to play... -
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- The effect of YB-1 antisense oligonucleotides on tumor cell growth
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Kim MS, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Jung YD, Kim SJ, Ahn BW, Shin BA
- KMID: 2081228
- Korean J Med.
- 2006 Sep;71(3):293-301.
BACKGROUND: Human YB-1 is a transcription factor that binds to the inverted CCAAT box in the promoter region of a variety of genes such as PCNA, DNA polymerase and MDR.... -
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- The Effects of TGF-beta2 and bFGF on the Proliferation of Retinal Pigment Epithelial Cells
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Yoon HS, Roh SH, Lee SC, Jeong JH, Yoo YH
- KMID: 2123999
- J Korean Ophthalmol Soc.
- 1998 Jun;39(6):1192-1203.
This study was undertaken to document the effect of transforming growth factor-beta2 (TGF-beta2(TGF-beta2) and basic fibroblast growth factor (bFGF) on the proliferation of pig retinal pigment epithelial cells (RPE). Whereas... -
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- Expression of Bcl-2 and Bax in cis-Diamminedichloroplatinum (II)-Resistant Bladder Cancer Cell Lines
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Song C, Kang TJ, You DS, Hong JH, Ahn HJ
- KMID: 2293492
- Korean J Urol.
- 2004 May;45(5):472-477.
PURPOSE: Development of drug resistance has been the major obstacle in cis-Diamminedichloroplatinum (II) (cisplatin)-based combination chemotherapy in the treatment of advanced bladder cancer for which a variety of mechanisms has... -
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- Gene Therapy for Muscular Dystrophies: Progress and Challenges
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Park KS, Oh D
- KMID: 1462846
- J Clin Neurol.
- 2010 Sep;6(3):111-116.
- doi: 10.3988/jcn.2010.6.3.111
Muscular dystrophies are groups of inherited progressive diseases of the muscle caused by mutations of diverse genes related to normal muscle function. Although there is no current effective treatment for... -
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- The Effect of ECMs on MHC Class II Molecule Expression in Retinal Pigment Epithelium
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Moon SC, Yoon HS, Yoo KW, Jeong JH, Yoo YH
- KMID: 2125131
- J Korean Ophthalmol Soc.
- 2001 Feb;42(2):355-364.
Expression of MHC class II molecule by retinal pigment epithelial cells and the interaction of the cell with extracellular matrix molecules involve in the pathogenesis of proliferative vitreoretinopathy and chorioretinitis.... -
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- Inhibition of HBV replication by antisense oligodeoxyribonucleotides in HepG2 cells transfected with a cloned HBV DNA
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Oh SH, Yeh BI, Kim SH
- KMID: 699865
- Yonsei Med J.
- 1995 Dec;36(6):527-533.
- doi: 10.3349/ymj.1995.36.6.527
The effect of antisense oligodeoxyribonucleotides(oligo[dN]s) on hepatitis B virus(HBV) replication in HepG2 cells harboring a cloned HBV genome was examined. Antisense oligo(dN)s directed at translational initiation sites of S, pre... -
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- Study on the Mitochondrial Dysfunction by p53 Regulation in Ceramide-induced Neuronal Cell Death
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Lee DY, Lee HJ, Noh YH, Yun JY, Han IS, Chung YH, Kim KY, Kim SS, Lee WB
- KMID: 1512990
- Korean J Phys Anthropol.
- 2006 Mar;19(1):49-59.
Ceramide induces cell death in a dose- and time-dependent manner in neuroblastoma SK-N-SH cells. To investigate the mechanism of SK-N-SH cell death by C2-ceramide, morphological features and Hoechst 33258 staining... -
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- Association of rOAT1 with Caveolin-1 in Rat Kidney
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Cha SH, Won YJ, Hwang JS, Suh CK
- KMID: 2253308
- Korean J Nephrol.
- 2008 Mar;27(2):175-185.
PURPOSE: A family of organic anion transporters (OAT) has been identified, and several isoforms have been reported. The regulatory mechanisms of OATs functions, however, still remain to be elucidated. The... -
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- Effect of Antisense TGF-beta1 Oligodeoxynucleotides in Streptozotocin-Induced Diabetic Rat Kidney
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Jeong HS, Park KK, Kim SP, Choi IJ, Lee IK, Kim HC
- KMID: 1786815
- J Korean Med Sci.
- 2004 Jun;19(3):374-383.
- doi: 10.3346/jkms.2004.19.3.374
Transforming growth factor (TGF)-beta1 is an important fibrogenic factor that is involved in the pathogenesis of diabetic nephropathy. We evaluated the effect of circular antisense TGF-beta1 oligodeoxynucleotides (ODNs) on the... -
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- Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death
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Yoo YD, Chung YM, Park JK, Ahn CM, Kim SK, Kim HJ
- KMID: 931877
- Exp Mol Med.
- 2002 Sep;34(4):273-277.
Peroxiredoxin II (Prx II) is known not only to protect cells from oxidative damage caused by hydrogen peroxide (H2O2), but also to endow cancer cells with resistance to both... -
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- Myeloablative Treatment Supported by Autologous Stem Cell Infusion with Neuroblastoma
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Ryu KH, Seoh JY, Jang PS, Kim CW, Koh SH, Shin HY, Ahn HS
- KMID: 2157620
- J Korean Med Sci.
- 2003 Apr;18(2):184-190.
- doi: 10.3346/jkms.2003.18.2.184
Bcr-abl antisense oligodeoxynucleotides (AS-ODNs) have provided evidence of an antileukemia effect when tested in vitro against Philadelphia-positive cells. In order to investigate the efficacy of AS-ODNs as purging agents in... -
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- Hsp27 contributes to estrogen regulation of osteoblast apoptosis
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Jang HS, Eune JJ, Rim JS, Kwon JJ, Choi CM
- KMID: 1961098
- J Korean Assoc Oral Maxillofac Surg.
- 2004 Aug;30(4):323-330.
Estrogen may promote osteoblast/osteocyte viability by limiting apoptotic cell death. We hypothesize that hsp27 is an estrogen- regulated protein that can promote osteoblast viability by increasing osteoblast resistance to apoptosis.... -
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- IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1
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Yu SJ, Kim HS, Cho SW, Sohn J
- KMID: 1094082
- Exp Mol Med.
- 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the... -
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- Characterization of Echinostoma cinetorchis endoribonuclease, RNase H
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Lim SB, Cha SH, Jegal S, Jun H, Park SH, Jeon BY, Pak JH, Bakh YY, Kim TS, Lee HW
- KMID: 2389984
- Korean J Parasitol.
- 2017 Aug;55(4):451-455.
- doi: 10.3347/kjp.2017.55.4.451
Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis... -
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- Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-alpha and IFNgamma-stimulated Primary Cultured Astrocytes
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Lee JK, Kim JK, Park SH, Sim YB, Jung JS, Suh HW
- KMID: 2071726
- Korean J Physiol Pharmacol.
- 2011 Oct;15(5):251-258.
- doi: 10.4196/kjpp.2011.15.5.251
Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-alpha and IFNgamma (CM)-stimulated astrocytes. We have observed that stimulation of astrocytes with CM increased the... -
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- Role of Nuclear Factor (NF)-kappaB Activation in Tumor Growth and Metastasis
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Ko HM, Choi JH, Ra MS, Im SY
- KMID: 2167969
- Immune Netw.
- 2003 Mar;3(1):38-46.
- doi: 10.4110/in.2003.3.1.38
BACKGROUND: Platelet-activating factor (PAF) induces nuclear factor (NF)-kappaB activation and angiogenesis and increases tumor growth and pulmonary tumor metastasis in vivo. The role of NF-kappaB activation in PAF-induced angiogenesis in... -
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