- Effects of Lipoxygenase Inhibitor on Diabetic Nephropathy in Rats: Decreasing Proteinuria and Preserving Renal Function
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Chung HC, Kim IY, Kim SR, Son J, Lee DW, Song SH, Seong EY, Kwak IS, Lee SB
- KMID: 2252632
- Korean J Nephrol.
- 2011 Sep;30(5):452-458.
PURPOSE: Oxidative stress leads to an increased production of lipoxygenase derivatives in diabetic nephropathy. Thus, we hypothesized that lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA), ha the effects of decreasing proteinuria and... -
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- Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat
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Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Yang BY, Lee MY, Sol MY
- KMID: 1778158
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S170-S175.
- doi: 10.3346/jkms.2009.24.S1.S170
5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin... -
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- Arachidonic Acid Activates K+-Cl--cotransport in HepG2 Human Hepatoblastoma Cells
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Lee YS
- KMID: 1982575
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):401-408.
- doi: 10.4196/kjpp.2009.13.5.401
K+-Cl--cotransport (KCC) has been reported to have various cellular functions, including proliferation and apoptosis of human cancer cells. However, the signal transduction pathways that control the activity of KCC are... -
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- Effects of Celecoxib and Nordihydroguaiaretic Acid on Puromycin Aminonucleoside-Induced Nephrosis in the Rat
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Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Chung HC, Yang BY, Lee MY, Sol MY
- KMID: 1778160
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S183-S188.
- doi: 10.3346/jkms.2009.24.S1.S183
The selective cyclooxygenase-2 (COX-2) and 5-lipoxygenase (LOX) inhibitors might inhibit prostaglandin synthesis and reduce proteinuria. The present study was designed to investigate the anti-proteinuric effects of nordihydroguaiaretic acid (NDGA) as... -
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- The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells
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Lim JC, Park SY, Nam Y, Nguyen TT, Sohn UD
- KMID: 1493963
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):313-320.
- doi: 10.4196/kjpp.2012.16.5.313
In this study, we focused to identify whether eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by... -
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- Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo
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Kim SY, Kim TB, Moon KA, Kim TJ, Shin D, Cho YS, Moon HB, Lee KY
- KMID: 1094126
- Exp Mol Med.
- 2008 Aug;40(4):461-476.
- doi: 10.3858/emm.2008.40.4.461
Reactive oxygen species (ROS) performs a pivotal function as a signaling mediator in receptor-mediated signaling. However, the sources of ROS in this signaling have yet to be determined, but may... -
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