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Enhanced neutrophil functions by recombinant human granulocyte colony-stimulating factor in diabetic patients with foot infections in vitro

Peck KR, Son DW, Song JH, Kim S, Oh MD, Choe KW

This study was performed to evaluate the effect of granulocyte-colony stimulating factor on neutrophil functions in diabetic patients with active foot infections in vitro. Twelve diabetic patients with foot infections...
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Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma

Park HS, Hwang SC, Nahm DH, Yim HE

Toluene diisocyanate (TDI) is the most prevalent agent in occupational asthma (OA) in Korea. The immuno-pathologic mechanism for TDI-induced bronchoconstriction remains to be clarified. We studied the immunohistochemical finding of...
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Sequential evolution of IL-17 responses in the early period of allograft rejection

Min SI, Ha J, Park CG, Won JK, Park YJ, Min SK, Kim SJ

In addition to CD4+CD25+Foxp3+ regulatory T (T(reg)) cells which protect against autoimmune tissue injury, IL-17-producing CD4+ T (Th17) cells have been recently described and shown to play a crucial role...
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Immunological abnormalities in patient with IgA nephropathy

Ihm CG, Woo JT, Chang YW, Kwon OS, Kim MJ

T cell immunity and phagocytic activity were studied in the blood of patients with IgA nephropathy in order to clarify their roles in the pathogenesis of IgA nephropathy. The percentages...
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A Case of Neonatal Alloimmune Neutropenia Associated with Anti-Human Neutrophil Antigen-1a (HNA-1a) Antibody

Han TH, Chey MJ, Han KS

Neonatal alloimmune neutropenia (NAN) is an uncommon disease of the newborn provoked by the maternal production of neutrophil-specific alloantibodies, whereby neutrophil IgG antibodies cross the placenta and induce the destruction...
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CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury

Kim MS, Lee KH, Lee WM, Jun JH, Kim DH

Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion...
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Phagocytic activity in familial Mediterranean fever

Keskin G, Inal A, Sengul A, Cindoruk M, Haznedaroglu S, Duranay M, Songur Y

Familial Mediterranean fever (FMF) is an autosomal recessive disease. Although the possibility of multiple immunologic mechanisms have been studied, the actual mechanism is still unresolved. Forty-one patients with FMF (24...
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The Role of Keratinocyte-derived Chemokine in Hemorrhage-induced Acute Lung Injury in Mice

Lee BH, Lee TJ, Jung JW, Oh DJ, Choi JC, Shin JW, Park IW, Choi BW, Kim JY

Dominant inflammatory cytokines might be different depending on the underlying causes of acute lung injury (ALI). The role of kertinocyte-derived chemokine (KC), a potent chemoattractant for neutrophils, has not been...
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Steroid Responsive Pancreatic Mass-Forming Type 2 Autoimmune Pancreatitis

Chun YJ, Chang JH, Lee IS, Lee JE, Chung MK, Jung CK, Choi MG, Chung IS

Autoimmune pancreatitis (AIP) has two distinct subsets. Type 1 AIP or lymphoplasmacytic sclerosing pancreatitis is systemic disease with the elevation in serum levels of the IgG4. Type 2 AIP, also...
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Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

Pham DL, Kim SH, Losol P, Yang EM, Shin YS, Ye YM, Park HS

BACKGROUND/AIMS: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic...
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The Role of Cyclosporine and Mycophenolate in an Orthotopic Porcine-to-Rat Corneal Xenotransplantation

Lee HI, Kim MK, Oh JY, Ko JH, Lee HJ, Wee WR, Lee JH

We performed this study to investigate the feature of rejection in porcine-to-rat corneal orthotopic transplantation and to evaluate the effect of cyclosporine and mycophenolate on the xeno-rejection. Orthotopic corneal transplantation...
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A Case of Sweet's Syndrome in a Patient with Liver Cirrhosis Caused by Chronic Hepatitis B

Park CW, Kim YJ, Seo HJ, Lee KI, Jang BK, Hwang JS, Chung WJ

Sweet's syndrome (SS), also known as acute febrile neutrophilic dermatosis, is characterized by the sudden onset of painful erythematous skin lesions together with fever and neutrophilia. SS can be associated...
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