- Mechanism of Neuronal Migration in Human Foetal Cerebrum In-vitro
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Choi BH
- KMID: 687776
- Yonsei Med J.
- 1979 Dec;20(2):92-104.
- doi: 10.3349/ymj.1979.20.2.92
Active migration of immature neurons occurs when fragments of human foetal cerebral tissues are explanted as organotypic cultures. The sequence of events during neuronal migration is orderly and consistent under... -
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- The effects of laminin on the characteristics and differentiation of neuronal cells from epidermal growth factor-responsive neuroepithelial cells
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Park DS, Park JS, Yeon DS
- KMID: 711537
- Yonsei Med J.
- 1998 Apr;39(2):130-140.
- doi: 10.3349/ymj.1998.39.2.130
Many extracellular matrix molecules are expressed in the embryonic nervous system and there is some evidence that they are important regulators of neural development. Of these molecules, laminin appears to... -
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- Cytotoxicity of gamma-ray in rat immature hippocampal neurons
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Yang M, Song MS, Kim SH, Kim JC, Kim JS, Shin T, Moon C
- KMID: 1067390
- J Vet Sci.
- 2011 Sep;12(3):203-207.
- doi: 10.4142/jvs.2011.12.3.203
This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy... -
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- c-fos Expression in Bladder-Specific Spinal Neurons after Spinal Cord Injury Using Pseudorabies Virus
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Im YJ, Hong CH, Jin MH, Lee BH, Han SW
- KMID: 724265
- Yonsei Med J.
- 2008 Jun;49(3):479-485.
- doi: 10.3349/ymj.2008.49.3.479
PURPOSE: c-fos expression in spinal neurons that are activated by lower urinary tract stimulation are not organ specific. In this experiment, we demonstrated changes of c-fos expression in bladder-specific preganglionic... -
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- Shank 2 expression coincides with neuronal differentiation in the developing retina
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Kim JH, Kim JH, Yang E, Park JH, Yu YS, Kim KW
- KMID: 1088598
- Exp Mol Med.
- 2009 Apr;41(4):236-242.
- doi: 10.3858/emm.2009.41.4.026
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation... -
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- Anti-oxidative neuroprotection by estrogens in mouse cortical cultures
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Bae YH, Hwang JY, Kim YH, Koh JY
- KMID: 1128633
- J Korean Med Sci.
- 2000 Jun;15(3):327-336.
- doi: 10.3346/jkms.2000.15.3.327
Estrogen replacement therapy in postmenopausal women may reduce the risk of Alzheimer's disease, possibly by ameliorating neuronal degeneration. In the present study, we examined the neuroprotective spectrum of estrogen against... -
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- Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neurons
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Moon IS, Cho SJ, Seog DH, Walikonis
- KMID: 1119326
- Exp Mol Med.
- 2009 Aug;41(8):601-610.
- doi: 10.3858/emm.2009.41.8.066
Activity-dependent dendritic translation in CNS neurons is important for the synapse-specific provision of proteins that may be necessary for strengthening of synaptic connections. A major rate-limiting factor during protein synthesis... -
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- Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells
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Kim BW, Son H
- KMID: 1115952
- Exp Mol Med.
- 2006 Dec;38(6):732-738.
It has been shown that neural cell adhesion molecule (NCAM)-induced neuronal differentiation is extracellular signal-regulated kinase (ERK)-dependent. However, an involvement of the mitogen activated protein kinase (MAPK) kinase (MEK), an... -
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- Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation
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Song J, Oh Y, Kim JY, Cho KJ, Lee JE
- KMID: 2427165
- Yonsei Med J.
- 2016 Nov;57(6):1461-1467.
- doi: 10.3349/ymj.2016.57.6.1461
PURPOSE: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects... -
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- Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
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Shin MH, Lee EG, Lee SH, Lee YS, Son H
- KMID: 1121093
- Exp Mol Med.
- 2002 Dec;34(6):401-410.
Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat embryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble... -
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- Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo
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Park KW, Lee HG, Jin BK, Lee YB
- KMID: 1091076
- Exp Mol Med.
- 2007 Dec;39(6):812-819.
A degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is expressed in LPS-injected rat cerebral... -
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- Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells
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Seo SR, Seo JT
- KMID: 1088602
- Exp Mol Med.
- 2009 Apr;41(4):269-276.
- doi: 10.3858/emm.2009.41.4.030
Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic... -
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- Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells
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Seo MS, Jeong YH, Park JR, Park SB, Rho KH, Kim HS, Yu KR, Lee SH, Jung JW, Lee YS, Kang KS
- KMID: 1726916
- J Vet Sci.
- 2009 Sep;10(3):181-187.
- doi: 10.4142/jvs.2009.10.3.181
Human umbilical cord blood-derived mesenchymal stem cells (MSCs) are known to possess the potential for multiple differentiations abilities in vitro and in vivo. In canine system, studying stem cell therapy... -
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- Inhibition of BETA2/NeuroD by Id2
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Ghil SH, Jeon YJ, Suh-Kim H
- KMID: 755209
- Exp Mol Med.
- 2002 Nov;34(5):367-373.
Id (Inhibitor of Differentiation) proteins belong to a family of transcriptional modulators that are characterized by a helix loop helix (HLH) region but lack the basic amino acid domain. Id... -
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- Neurotoxicity Screening in a Multipotent Neural Stem Cell Line Established from the Mouse Brain
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Choi YS, Lee MC, Kim HS, Lee KH, Park YG, Kim HK, Jeong HS, Kim MK, Woo YJ, Kim SU, Ryu JK, Choi HB
- KMID: 1778041
- J Korean Med Sci.
- 2010 Mar;25(3):440-448.
- doi: 10.3346/jkms.2010.25.3.440
Neural stem cells (NSCs) have mainly been applied to neurodegeneration in some medically intractable neurologic diseases. In this study, we established a novel NSC line and investigated the cytotoxic responses... -
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- Toxic effects of methylmercury, arsanilic acid and danofloxacin on the differentiation of mouse embryonic stem cells into neural cells
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Kang SJ, Jeong SH, Kim EJ, Park YI, Park SW, Shin HS, Son SW, Kang HG
- KMID: 1737611
- J Vet Sci.
- 2014 Mar;15(1):61-71.
- doi: 10.4142/jvs.2014.15.1.61
This study was performed to assess the neurotoxic effects of methylmercury, arsanilic acid and danofloxacin by quantification of neural-specific proteins in vitro. Quantitation of the protein markers during 14 days... -
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- Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
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Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG
- KMID: 1105280
- Exp Mol Med.
- 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,... -
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- The biologic role of ganglioside in neuronal differentiation: effects of GM1 ganglioside on human neuroblastoma SH-SY5Y cells
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Lee MC, Lee WS, Park CS, Juhng SW
- KMID: 1422174
- J Korean Med Sci.
- 1994 Apr;9(2):179-187.
- doi: 10.3346/jkms.1994.9.2.179
Human neuroblastoma SH-SY5Y cell is a cloned cell line which has many attractive features for the study of neuronal proliferation and neurite outgrowth, because it has receptors for insulin, IGF-I... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- Protective effects of fustin, a flavonoid from Rhus verniciflua tokes, on 6-hydroxydopamine-induced neuronal cell death
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Park BC, Lee YS, Park HJ, Kwak MK, Yoo BK, Kim JY, Kim JA
- KMID: 1047082
- Exp Mol Med.
- 2007 Jun;39(3):316-326.
6-Hydroxydopamine (6-OHDA) is a neurotoxin and is commonly used to generate experimental models of Parkinson's disease (PD). In this study, we investigated the signaling molecules involved in the 6-OHDA-induced cell... -
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