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Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes

Nam SM, Kim JW, Yoo DY, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS

In this study, we investigated the effects of chronic aluminum (Al) exposure for 10 weeks on cell proliferation and neuroblast differentiation in the hippocampus of type 2 diabetic rats. Six-week-old...
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Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation

Song J, Oh Y, Kim JY, Cho KJ, Lee JE

PURPOSE: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects...
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Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress

Nam SM, Kim JW, Yoo DY, Kim W, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS

Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer's disease. In this study, we investigated the effects of Al and/or...
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Cell proliferation and neuroblast differentiation in the dentate gyrus of high-fat diet-fed mice are increased after rosiglitazone treatment

Yoo DY, Kim W, Kim DW, Nam SM, Jung HY, Kim JW, Lee CH, Choi JH, Won MH, Yoon YS, Hwang IK

In this study, we determined how rosiglitazone (RSG) differentially affected hippocampal neurogenesis in mice fed a low-fat diet (LFD) or high-fat diet (HFD; 60% fat). LFD and HFD were given...
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