- High Activities of Protein Kinases C and M in Fresh Human Stomach and Breast Tumors
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Lim IK, Lee DJ, Lee KH, Yun TK
- KMID: 1095740
- Yonsei Med J.
- 1987 Dec;28(4):255-260.
- doi: 10.3349/ymj.1987.28.4.255
The activities of Ca+2-PL dependent protein Kinase (PKC) and independent protein kinase(RKM) were measured in human stomach and breast tumors and in the respective counterparts of normal tissue. Expression of... -
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- WNKs: protein kinases with a unique kinase domain
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Huang CL, Cha SK, Wang HR, Xie J, Cobb MH
- KMID: 1090959
- Exp Mol Med.
- 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in... -
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- Anti-tumor mechanisms and regulation of survivin by selective cyclooxygenase-2 inhibitor
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Jang JW
- KMID: 1381460
- Korean J Hepatol.
- 2008 Sep;14(3):305-308.
- doi: 10.3350/kjhep.2008.14.3.305
No abstract available. -
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- Telomerase is strongly activated in hepatocellular carcinoma but not in chronic hepatitis and cirrhosis
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Park YM, Choi JY, Byun BH, Cho CH, Kim HS, Kim BS
- KMID: 754985
- Exp Mol Med.
- 1998 Mar;30(1):35-40.
Telomerase is highly activated in human immortal cell lines and tumor tissues, whereas it is not activated in primary cell strains and many tumor-adjacent tissues. It is suggested that telomerase activation is... -
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- Immunohistochemical expression of h-telomerase reverse transcriptase in canine and feline meningiomas
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Mandrioli , Panarese S, Cesari A, Mandara MT, Marcato PS, Bettini G
- KMID: 1089660
- J Vet Sci.
- 2007 Jun;8(2):111-115.
- doi: 10.4142/jvs.2007.8.2.111
Telomere length maintenance is regarded as a fundamental step in tumorigenesis, as most human brain tumors, including meningiomas, stabilize the ends of their chromosomes using telomerase. This investigation represents an... -
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- Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma
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Joo YE, Seo KS, Kim J, Kim HS, Rew JS, Park CS, Kim SJ
- KMID: 1731316
- J Korean Med Sci.
- 1999 Aug;14(4):417-423.
- doi: 10.3346/jkms.1999.14.4.417
Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial... -
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- Cyclooxygenase-2 Expression according to Size and Location of Gastric and Colorectal Tubular Adenomas
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Kim SH, Lee JH, Kang KH, Park JH, Park CK, Cho CM, Kweon YO, Kim SK, Choi YH, Bae HI, Kim MS
- KMID: 1113421
- Korean J Gastroenterol.
- 2004 Oct;44(4):206-211.
BACKGROUND/AIMS: Recent studies have shown that cyclooxygenase-2 (COX-2) may be involved in the process of invasion, growth and apoptosis in colorectal carcinoma and in the growth and tumorigenesis in... -
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- Hepatitis C virus genotypes in Korea and their relationship to clinical outcome in type C chronic liver diseases
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Han CJ, Lee HS, Kim HS, Choe JH, Kim CY
- KMID: 1038875
- Korean J Intern Med.
- 1997 Jan;12(1):21-27.
OBJECTIVES: The relationship between HCV genotype and the development of more serious liver disease has not been clearly established. This study was to investigate the distribution pattern of HCV genotypes... -
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- Prevalence of viral hepatitis markers in Korean patients with hepatocellular carcinoma
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Huh K, Choi SY, Whang YS, Lee DS
- KMID: 1745555
- J Korean Med Sci.
- 1998 Jun;13(3):306-310.
- doi: 10.3346/jkms.1998.13.3.306
The positive rates of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV) were analyzed according to year, sex, age, and serum ALT levels in 1,370... -
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- A Case of Primary Gastric CD30-Positive Anaplastic Large-Cell Lymphoma
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Song HH, Baik GH, Kwon JH, Lee KS, Choi YH, Choi KC, Park YE
- KMID: 2157763
- J Korean Med Sci.
- 2005 Dec;20(6):1062-1065.
- doi: 10.3346/jkms.2005.20.6.1062
Gastric CD30-positive anaplastic large-cell lymphoma is a very rare disease. It is sometimes difficult to distinguish it from undifferentiated carcinoma, sarcoma and so on. We report here on a case... -
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- Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer
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Ko BK, Cho HR, Choi DW, Nam CW, Park CJ, Kim GY, Kim SS, Woo YJ, Huh J, Kim MY
- KMID: 1745551
- J Korean Med Sci.
- 1998 Jun;13(3):286-290.
- doi: 10.3346/jkms.1998.13.3.286
The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis of human cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes and their... -
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- Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression
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Hur JH, Park MJ, Park IC, Yi DH, Rhee CH, Hong SI, Lee SH
- KMID: 1128630
- J Korean Med Sci.
- 2000 Jun;15(3):309-314.
- doi: 10.3346/jkms.2000.15.3.309
To evaluate possible roles of matrix metalloproteinase (MMP)-1, -2, tissue inhibitor of metalloproteinase (TIMP)-1, -2 and membrane-type-1 matrix metalloproteinase (MT1-MMP) in invasion of human gliomas, expressions of these proteins were... -
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- Alternative splicing in 5'-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines
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Shin SO, Lee KH, Kim JH, Baek SH, Park JW, Gabrielson EW, Kwon TK
- KMID: 755098
- Exp Mol Med.
- 2000 Dec;32(4):193-196.
Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and, execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there... -
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- Expression of Neutrophil Gelatinase-Associated Lipocalin in Calcium-Induced Keratinocyte Differentiation
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Lee JH, Kye KC, Seo EY, Lee K, Lee SK, Lim JS, Seo YJ, Kim CD, Park JK
- KMID: 1713465
- J Korean Med Sci.
- 2008 Apr;23(2):302-306.
- doi: 10.3346/jkms.2008.23.2.302
In a previous search for the differentially expressed genes in keratinocyte differentiation, we identified neutrophil gelatinase-associated lipocalin (NGAL) as a calcium- induced gene. In this study, we further verified the... -
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- Expression of Cyclooxygenase-2 and Its Correlation with Clinicopathologic Factors of Ampulla of Vater Cancer
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Kim HJ, Sohn TS, Lee KT, Lee JK, Paik SW, Rhee JC
- KMID: 2157625
- J Korean Med Sci.
- 2003 Apr;18(2):218-224.
- doi: 10.3346/jkms.2003.18.2.218
There has been no report for the expression of cyclooxygenase-2 (COX-2) and its clinicopathologic and biologic significance in ampulla of Vater cancer. This study was aimed for the clarification of... -
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- Newer treatments for advanced hepatocellular carcinoma
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Song MJ, Bae SH
- KMID: 1792028
- Korean J Intern Med.
- 2014 Mar;29(2):149-155.
- doi: 10.3904/kjim.2014.29.2.149
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The only curative treatment modalities for HCC are surgery, percutaneous ablation, and liver transplantation. Unfortunately, the majority of patients... -
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- Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery
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Lee DY, Yang DH, Kang CW, Kim SJ, Joo CU, Cho SC, Kim JS
- KMID: 645026
- J Korean Med Sci.
- 1997 Feb;12(1):32-39.
- doi: 10.3346/jkms.1997.12.1.32
Recent findings have indicated that insulin-like growth factors (IGF-I and IGF-II) may play a role in neoplasia. Alteration of serum IGFs or IGF Binding Proteins (IGFBPs) have been reported... -
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- Immunohistochemical Analysis of Nuclear Factor, p38, and Cyclin D1 Proteins in Premalignant Lesions and Carcinomas of the Colorectal Mucosa
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Lee SD, Lee TJ, Park ES
- KMID: 783112
- Korean J Gastroenterol.
- 2008 Dec;52(6):359-367.
BACKGROUND/AIMS: Nuclear factor-kappa B p65 (NF-kappa B p65), nuclear factor-kappa B1 p50 (NF-kappa B p50) have been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis.... -
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- The Effect of Cyclooxygenase-2 Expression on Tumor Volume Response in Patients Treated with Radiotherapy for Uterine Cervical Cancer
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Kang MK, Park W, Choi YL, Cho EY, Ahn G, Nam H, Huh SJ, Ahn YC, Lim DH, Oh DR, Bae DS, Kim BG
- KMID: 1783150
- J Korean Med Sci.
- 2009 Dec;24(6):1170-1176.
- doi: 10.3346/jkms.2009.24.6.1170
We investigated the correlation between Cyclooxygenase-2 (COX-2) expression and the tumor response in patients with cervical cancer that were treated with curative radiotherapy (RT). Fifty-seven patients with squamous cell carcinoma... -
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- CYP1A2 activity as a risk factor for bladder cancer
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Lee SW, Jang IJ, Shin SG, Lee KH, Yim DS, Kim SW, Oh SJ, Lee SH
- KMID: 644840
- J Korean Med Sci.
- 1994 Dec;9(6):482-489.
- doi: 10.3346/jkms.1994.9.6.482
CYP1A2, CYP2D6 and N-acetyltransferase activities were estimated in 100 patients with bladder cancer and 84 control subjects from measurements of theophylline, metoprolol and isoniazid and their metabolites in urine, respectively.... -
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