J Korean Med Sci.  2005 Dec;20(6):1062-1065. 10.3346/jkms.2005.20.6.1062.

A Case of Primary Gastric CD30-Positive Anaplastic Large-Cell Lymphoma

• Song HH
• Baik GH
• Kwon JH
• Lee KS
• Choi YH
• Choi KC
• Park YE

• KMID: 2157763
• DOI: http://doi.org/10.3346/jkms.2005.20.6.1062

Abstract

Gastric CD30-positive anaplastic large-cell lymphoma is a very rare disease. It is sometimes difficult to distinguish it from undifferentiated carcinoma, sarcoma and so on. We report here on a case of primary gastric anaplastic large-cell lymphoma. A 50-yr-old woman complained of epigastric pain and severe chest pain for 1 week. The gastroendoscopic examination revealed geographic mucosal irregularities with shallow ulceration at the antrum. She underwent a total gastrectomy. The gross finding of the resected stomach was an 8 x 4.5 cm sized ulceroinfiltrative lesion at the pyloric antrum along the lesser curvature. The microscopic examination revealed diffuse and solid proliferations of large atypical cells with pleomorphic nuclei. Immunohistochemically, the tumor cells were positive for CD30, vimentin and CD3, and this was a finding compatible with anaplastic large-cell lymphoma. To the best of our knowledge, this is the first such reported case in Korea.

Keyword

Antigens, CD30; Lymphoma Large-Cell, Ki-1; Stomach Neoplasms; Immunohistochemistry

MeSH Terms

Antigens, CD30/*metabolism
Female
Humans
Immunohistochemistry
Korea
Lymphoma, Large-Cell/enzymology/*immunology/*pathology
Middle Aged
Protein-Tyrosine Kinase/metabolism
Stomach Neoplasms/enzymology/*immunology/*pathology

Figure

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  Fig. 1 Gastroendoscopy shows a geographic mucosal irregularity at the antrum (A). Endoscopic ultrasonography shows submucosal thickening of the stomach (arrows) (B).

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  Fig. 2 A macroscopic picture of the total gastrectomy specimen. The ulceroinfiltrative mass measuring 8×4.5 cm can be seen on the lesser curvature of the antrum.

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  Fig. 3 Histologic and immunohistochemical pictures of the gastric tumor. A high power view (H&E, ×400) shows a diffuse and solid proliferation of large atypical cells with pleomorphic nuclei. Multiple nuclear lobulations are noted (A). Positive immunoreactivity with anti-CD30 (×400) and (B), negative immunoreactivity for ALK (×400) (C).

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