- Studies on the Cytotoxicity and Antineoplastic Activity of Methyl Gallate
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Han DS, Lee SR, Jung WY
- KMID: 1558427
- Korean J Anat.
- 2001 Apr;34(2):131-139.
In order to develop antitumor agent which indicates weak side effects and strong antitumor activity, cytotoxicity and antitumor effects of MG was evaluated by MTT assay and SRB assay of... -
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- The optimal conditions to improve retrovirus-mediated transduction efficiency to NIH 3T3 cells
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Lee JA, Lee KM, Lee HJ, Lee YJ, Kim DH, Lim JS, Park KD
- KMID: 2279316
- Korean J Pediatr.
- 2007 Oct;50(10):1011-1017.
- doi: 10.3345/kjp.2007.50.10.1011
PURPOSE: We tried to assess the optimal conditions to improve low transduction efficiency and their effect on target cells. METHODS: Cultured NIH 3T3 cells were incubated with retroviral vectors bearing an... -
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- Candida spp.- Induced Cytokine Gene Expression on Mouse Peritoneal Macrophages and NIH 3T3 Fibroblasts
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Kim HS, Kim SK, Lee YS, Kim SD
- KMID: 1551638
- J Korean Soc Microbiol.
- 1998 Jun;33(3):237-245.
Interaction with Candida albicans (C. albicans) causes secretion of a variety of cytokines by macrophages. Although macrophages and neutrophils are thought to be major effector cell types in inflammation, fibroblasts... -
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- The Difference in Biological Properties between Parental and v-Ha-ras Transformed NIH3T3 Cells
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Lee M, Ahn JH, Eum KH
- KMID: 2165985
- Cancer Res Treat.
- 2009 Jun;41(2):93-99.
PURPOSE: We performed experiments to investigate the change in cellular signaling that occurs during the transformation of a normal cell to a cell capable of cancerous growth, and we did... -
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- The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement
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Begum R, Nur-E-Kamal MSA, Zaman MA
- KMID: 1094080
- Exp Mol Med.
- 2004 Aug;36(4):358-366.
The rearrangement of the actin cytoskeleton has been shown to play a critical role in the development of transformation and malignant phenotype of cancer cells. Rho family GTPases regulate the... -
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- Tissue engineering of dental pulp on type I collagen
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Lee GH, Huh SY, Park SH
- KMID: 2175631
- J Korean Acad Conserv Dent.
- 2004 Jul;29(4):370-377.
- doi: 10.5395/JKACD.2004.29.4.370
The purpose of this study was to regenerate human dental pulp tissues similar to native pulp tissues. Using the mixture of type I collagen solution, primary cells collected from the... -
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- Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3
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Kim MS, Koland JG
- KMID: 1581029
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular... -
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- Role of Pertussis Toxin-sensitive G Protein-coupled Receptor Signaling in the Proliferation of Bone Marrow Mesenchymal Stem Cells
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Kim SW, Hwang JH, Jin SA, Yun GW, Yang YJ, Park NW, Lee HJ, Yun HJ, Jo DY, Kim S
- KMID: 2252265
- Korean J Hematol.
- 2007 Mar;42(1):24-32.
- doi: 10.5045/kjh.2007.42.1.24
BACKGROUND: Bone marrow (BM) mesenchymal stem cells (MSCs) can be expanded over 20~30 cell doublings in vitro even in the absence of any growth factors. However, the mechanisms that govern... -
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- The Effect of GTP Cyclohydrolase I on the Activity and Expression of Tyrosine Hydroxylase and Cell Growth
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Lee YJ, Han IS, Yi SD
- KMID: 2342761
- J Korean Neurol Assoc.
- 1999 Jan;17(1):122-130.
BACKGROUND: Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by resting tremor, rigidity, and bradykinesia. L-3,4-dihydroxyphenylalanine (L-dopa) has been used for over last 3 decades to treat this disorder,... -
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- Differentially Expressed Proteins in Nitric Oxide-Stimulated NIH/3T3 Fibroblasts: Implications for Inhibiting Cancer Development
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Shim DH, Lim JW, Kim H
- KMID: 2070039
- Yonsei Med J.
- 2015 Mar;56(2):563-571.
- doi: 10.3349/ymj.2015.56.2.563
PURPOSE: Recent evidence shows that nitric oxide (NO) may exhibit both pro-cancer and anti-cancer activities. The present study aimed to determine the differentially expressed proteins in NO-treated NIH/3T3 fibroblasts in... -
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- Activation Of H-Ras Oncogene In Rat Salivary Gland Tumors Induced By Dmba And Irradiation
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Hu KS, Choi JW, Choi SC, Park TW, You DS
- KMID: 1537338
- J Korean Acad Oral Maxillofac Radiol.
- 1998 Feb;28(1):245-259.
Cellular transforming genes have been identified in a number of different tumor cell lines and tumor types. A significant number of these oncogenes belong to the ras gene family. The... -
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- Mutation of Ha-ras Oncogene in Rat Salivary Gland Tumors Induced by DMBA
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Yeh BI, Han DP, Sohn JH, Yoon JH, Lee HA, Chang SJ, Kong ID, Kim HW, Choi JW
- KMID: 2166224
- Cancer Res Treat.
- 2001 Dec;33(6):495-499.
PURPOSE: The incidence of salivary gland tumor is approximately 2% among all head and neck tumors, of which malignant cases account for only about 5%. Much research has been performed... -
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- Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription
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Lee J, Chun SK, Son GH, Kim K
- KMID: 2407090
- Endocrinol Metab.
- 2015 Sep;30(3):381-388.
- doi: 10.3803/EnM.2015.30.3.381
BACKGROUND: Hes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we... -
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- Differential Physiological Effects of Raf-1 Kinase Pathways Linked to Protein Kinase C Activation Depending on the Stimulus in v-H-ras-transformed Cells
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Lee M
- KMID: 2166000
- Cancer Res Treat.
- 2008 Jun;40(2):39-44.
PURPOSE: We investigated the molecular mechanism by which the Raf-1 kinase pathways that are linked to protein kinase C induce differential physiological effects, depending on the stimulus, by employing the... -
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- T-cell immune regulator 1 enhances metastasis in hepatocellular carcinoma
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Yang HD, Eun JW, Lee KB, Shen Q, Kim HS, Kim SY, Seo DW, Park WS, Lee JY, Nam SW
- KMID: 2438350
- Exp Mol Med.
- 2018 Jan;50(1):e420.
- doi: 10.1038/emm.2017.166
Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative gene expression analysis with recurrent... -
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- p21-activated kinase 1 is allostericallyInhibited by naphthoquinone (NQ) derivatives
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Oh SW, Lee KI, Choi JK, Kim KA, Kim EG, Shin EY
- KMID: 2394586
- J Biomed Transl Res.
- 2017 Jun;18(2):43-49.
- doi: 10.12729/jbtr.2017.18.2.043
The p21-activated kinases (PAKs) are a family of serine/threonine protein kinases and activated by binding with activated Rho GTPases such as Rac or Cdc42. PAKs regulate actin cytoskeletal remodeling, cell... -
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- Histological Method to Study the Effect of Shear Stress on Cell Proliferation and Tissue Morphology in a Bioreactor
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Chabanon M, Duval H, Grenier J, Beauchesne C, Goyeau B, David B
- KMID: 2449234
- Tissue Eng Regen Med.
- 2019 Jun;16(3):225-235.
- doi: 10.1007/s13770-019-00181-3
BACKGROUND: Tissue engineering represents a promising approach for the production of bone substitutes. The use of perfusion bioreactors for the culture of bone-forming cells on a three-dimensional porous scaffold resolves... -
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- Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin
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Kang BS, Ahn JY, Kim MK, Kim HJ, Kang L, Lim HC, Park KS, Lee JS, Seo JS, Cha CI, Kim SU, Park YJ, Kim M
- KMID: 1103679
- Exp Mol Med.
- 2007 Feb;39(1):38-46.
Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal system, where proteolytic fragments of... -
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- Effects of N-acetyl-L-cysteine and Glutathione on Antioxidant Status of Human Serum and 3T3 Fibroblasts
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Hong SY, Yang JO, Lee EY, Lee ZW
- KMID: 1130033
- J Korean Med Sci.
- 2003 Oct;18(5):649-654.
- doi: 10.3346/jkms.2003.18.5.649
The effectiveness of several sulfhydryl compounds in the treatment of paraquat intoxication has been previously tested based on their antioxidant ability. However, practical guidelines for their clinical use remain to... -
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- Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells
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Kim J, Choi BH, Jang KL, Min DS
- KMID: 1123766
- Exp Mol Med.
- 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast... -
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