- The Role of NF-kappaB in Colon Cancer
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Seo GS
- KMID: 991461
- Korean J Gastroenterol.
- 2011 Jan;57(1):3-7.
- doi: 10.4166/kjg.2011.57.1.3
Colon cancer is the 3rd common malignancy and 4th common cause of cancer death in Korea. Recent studies have shown that abnormal inflammatory response plays a critical role in colon... -
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- Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas
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Kim HJ, Park JK, Kim YG
- KMID: 646309
- J Korean Med Sci.
- 1999 Jun;14(3):299-303.
- doi: 10.3346/jkms.1999.14.3.299
T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB. We determined the mechanism of NF-kappaB suppression in T... -
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- Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis
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Jue DM, Jeon KI, Jeong JY
- KMID: 646299
- J Korean Med Sci.
- 1999 Jun;14(3):231-238.
- doi: 10.3346/jkms.1999.14.3.231
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint swelling and progressive destruction of cartilage and bone. Current RA treatments are largely empirical in origin and their... -
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- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Inflammation and Cancer Development in Pancreatic and Biliary Tract Cancer
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Lee SH, Park SW
- KMID: 2373366
- Korean J Gastroenterol.
- 2015 Dec;66(6):325-339.
- doi: 10.4166/kjg.2015.66.6.325
Chronic inflammation has been known to be a risk for many kinds of cancers, including pancreatic and biliary tract cancer. Recently, inflammatory process has emerged as a key mediator of... -
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- NF-kB and cytokines in pancreatic acinar cells
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Kim H, Seo JY, Kim KH
- KMID: 1026952
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S53-S54.
- doi: 10.3346/jkms.2000.15.S.S53
Reactive oxygen species (ROS), generated by infiltrating neutrophils, are considered as an important regulator in the pathogenesis and deveolpment of pancreatitis. A hallmark of the inflammatory response is the induction... -
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- Anti-inflammatory Mechanism of Lactobacillus rhamnosus GG in Lipopolysaccharide-stimulated HT-29 Cell
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Lee SK, Yang KM, Cheon JH, Kim TI, Kim WH
- KMID: 1387336
- Korean J Gastroenterol.
- 2012 Aug;60(2):86-93.
- doi: 10.4166/kjg.2012.60.2.86
BACKGROUND/AIMS: Probiotics are live non-pathogenic organisms that belong to the resident microflora, and confer health benefits by multiple mechanisms. Lactobacillus rhamnosus GG (LGG) is one of the probiotic bacteria that... -
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- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
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Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
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- B6C3F1 mice exposed to ozone with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-kappaB, AP-1, Nrf2, and osteopontin
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Kim MY, Song KS, Park GH, Chang SH, Kim HW, Park JH, Jin H, Eu KJ, Cho HS, Kang G, Kim YC, Cho MH
- KMID: 1120069
- J Vet Sci.
- 2004 Jun;5(2):131-137.
Toxic effects of ozone, 4-(N-methyl-N-nitrosamino)-1-(3- pyridyl)-1-butanone (NNK), and/or dibutyl phthalate (DBP) were examined through NF-kappaB, AP-1, Nrf2, and osteopontin (OPN) in lungs and livers of B6C3F1 mice. Electrophoretic mobility shift... -
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- Methylglyoxal Induces Apoptosis Mediated by Reactive Oxygen Species in Bovine Retinal Pericytes
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Kim J, Son JW, Lee JA, Oh YS, Shinn SH
- KMID: 1785701
- J Korean Med Sci.
- 2004 Feb;19(1):95-100.
- doi: 10.3346/jkms.2004.19.1.95
One of the histopathologic hallmarks of early diabetic retinopathy is the loss of pericytes. Evidences suggest that the pericyte loss in vivo is mediated by apoptosis. However, the underlying cause... -
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- Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
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Lee HY, Rhee CK, Kang JY, Park CK, Lee SY, Kwon SS, Kim YK, Yoon HK
- KMID: 2373777
- Korean J Intern Med.
- 2016 Jan;31(1):89-97.
- doi: 10.3904/kjim.2016.31.1.89
BACKGROUND/AIMS: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects... -
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- Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells
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Lee KJ, Kim YM, Kim DY, Jeoung D, Han K, Lee ST, Lee YS, Park KH, Park JH, Kim DJ, Hahn JH
- KMID: 1110120
- Exp Mol Med.
- 2006 Aug;38(4):364-374.
Heat shock protein 70 (Hsp70) release and its effects on pro-inflammatory cytokine production have been controversial. In this study, we investigated whether Hsp70 could be released from monocytes and activates... -
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- Expression of MicroRNA in Host Cells Infected with Helicobacter pylori
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Chung JW, Jeong SH, Lee SM, Pak JH, Lee GH, Jeong JY, Kim JH
- KMID: 2412213
- Gut Liver.
- 2017 May;11(3):392-400.
- doi: 10.5009/gnl16265
BACKGROUND/AIMS: MicroRNAs (miRNAs) regulate gene expression. We assess miRNA regulation by Helicobacter pylori infection and elucidate their role in H. pylori-infected gastric epithelial cells. METHODS: The relationship between miRNA expression and... -
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- Induction of nitric oxid esynthase(NOS) by soluble glucocorticoid induced tumor necrosis factor receptor(sGITR) is modulated by IFN-g in murine macrophage
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Shin HH, Lee HW, Choi HS
- KMID: 1094698
- Exp Mol Med.
- 2003 Jun;35(3):175-180.
Earlier study showed that glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, activated murine macrophages to express inducible nitric oxide synthase (iNOS) and to generate nitric oxide... -
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- Intrinsic Cellular Defenses against Virus Infection by Antiviral Type I Interferon
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Boo KH, Yang JS
- KMID: 1779600
- Yonsei Med J.
- 2010 Jan;51(1):9-17.
- doi: 10.3349/ymj.2010.51.1.9
Intrinsic cellular defenses are non-specific antiviral activities by recognizing pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs), one of the pathogen recognize receptor (PRR), sense various microbial ligands. Especially, TLR2, TLR3,... -
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- Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils
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Kim BJ, Kim JY, Hwang ES, Kim JG
- KMID: 2155644
- Gut Liver.
- 2015 May;9(3):358-369.
- doi: 10.5009/gnl13218
BACKGROUND/AIMS: The cytosolic host protein nucleotide binding oligomerization domain 1 (Nod1) has emerged as a key pathogen recognition molecule for innate immune responses in epithelial cells. The purpose of the... -
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- Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice
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Nam KH, Choi JH, Seo YJ, Lee YM, Won YS, Lee MR, Lee MN, Park JG, Kim YM, Kim HC, Lee CH, Lee HK, Oh SR, Oh GT
- KMID: 1110129
- Exp Mol Med.
- 2006 Aug;38(4):445-452.
We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal... -
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- TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts
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Park ES, Kim J, Ha TU, Choi JS, Hong KS, Rho J
- KMID: 2154254
- Exp Mol Med.
- 2013 Aug;45(8):e35.
Apoptosis has an important role in maintaining tissue homeostasis in cellular stress responses such as inflammation, endoplasmic reticulum stress, and oxidative stress. T-cell death-associated gene 51 (TDAG51) is a member... -
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- Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury
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Kim JY, Lee YW, Kim JH, Lee WT, Park KA, Lee JE
- KMID: 2164481
- J Korean Med Sci.
- 2015 Jul;30(7):943-952.
- doi: 10.3346/jkms.2015.30.7.943
Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after... -
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- Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin
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Kim BH, Oh I, Kim JH, Jeon JE, Jeon B, Shin J, Kim TY
- KMID: 2155352
- Exp Mol Med.
- 2014 Mar;46(3):e87.
- doi: 10.1038/emm.2013.157
Inflammation is a part of the complex biological responses of a tissue to injury that protect the organ by removing injurious stimuli and initiating the healing process, and is considered... -
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