- Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
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Kim KA, Min A, Lee YA, Shin MH
- KMID: 1792210
- Korean J Parasitol.
- 2014 Oct;52(5):459-469.
- doi: 10.3347/kjp.2014.52.5.459
Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of... -
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- Overexpression of bone morphogenetic protein 4 in STO fibroblast feeder cells represses the proliferation of mouse embryonic stem cells in vitro
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Kim GH, Lee GR, Choi HI, Park NH, Chung HT, Han IS
- KMID: 1397450
- Exp Mol Med.
- 2012 Jul;44(7):457-463.
Embryonic stem cells (ESCs) can be propagated in vitro on feeder layers of mouse STO fibroblast cells. The STO cells secrete several cytokines that are essential for ESCs to maintain... -
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- Inhibitory Effect of Melanoma Differentiation Associated Gene-7/Interleukin-24 on Invasion In Vitro of Human Melanoma Cancer Cells
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Lin BW, Jiao ZL, Fan JF, Peng L, Li L, Zhao ZG, Ding XY, Li HJ
- KMID: 2158029
- J Korean Med Sci.
- 2013 Jun;28(6):833-839.
- doi: 10.3346/jkms.2013.28.6.833
The acquisition of metastasis potential is a critical point for malignant tumors. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a potential tumor suppress gene and frequently down-regulated in malignant tumors. It... -
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- beta-irradiation (166Ho patch)-induced skin injury in mini-pigs: effects on NF-kappaB and COX-2 expression in the skin
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Kim JS, Rhim KJ, Jang WS, Lee SJ, Son Y, Lee SS, Park S, Lim SM
- KMID: 2160814
- J Vet Sci.
- 2015 Mar;16(1):1-9.
- doi: 10.4142/jvs.2015.16.1.1
In the present study, the detrimental effect of beta-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of... -
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- TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells
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Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS
- KMID: 1103688
- Exp Mol Med.
- 2007 Feb;39(1):121-127.
TNF-alpha plays a variety of biological functions such as apoptosis, inflammation and immunity. PTEN also has various cellular function including cell growth, proliferation, migration and differentiation. Thus, possible relationships between... -
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- Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration
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Kwon HJ, Hong SK, Yoon WK, Nam KH, Choi IP, Kim DY, Kim HC, Won YS
- KMID: 1705555
- J Vet Sci.
- 2013 Sep;14(3):257-262.
- doi: 10.4142/jvs.2013.14.3.257
Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1... -
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- Chemopreventive and metabolic effects of inulin on colon cancer development
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Hijova E, Szabadosova V, Stofilova , Hrckova G
- KMID: 1712304
- J Vet Sci.
- 2013 Dec;14(4):387-393.
- doi: 10.4142/jvs.2013.14.4.387
Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4... -
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- The efficacy of SPA0355 in protecting beta cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
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Bae UJ, Song MY, Jang HY, Gim HJ, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2154270
- Exp Mol Med.
- 2013 Nov;45(11):e51.
Cytokines activate several inflammatory signals that mediate beta-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting beta cells from various insults.... -
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- Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling
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Lee JS, Park SY, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA
- KMID: 983987
- Exp Mol Med.
- 2010 Feb;42(2):143-154.
- doi: 10.3858/emm.2010.42.2.016
TNF-alpha is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through... -
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- Isoflavone-deprived soy peptide suppresses mammary tumorigenesis by inducing apoptosis
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Park K, Choi K, Kim H, Kim K, Lee MH, Lee JH, Kim Rim JC
- KMID: 756229
- Exp Mol Med.
- 2009 Jun;41(6):371-380.
- doi: 10.3858/emm.2009.41.6.042
During carcinogenesis, NF-kappaB mediates processes associated with deregulation of the normal control of proliferation, angiogenesis, and metastasis. Thus, suppression of NF-kappaB has been linked with chemoprevention of cancer. Accumulating findings... -
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- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy
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Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS
- KMID: 2468272
- J Korean Med Sci.
- 2016 Sep;31(9):1403-1412.
- doi: 10.3346/jkms.2016.31.9.1403
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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- Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells
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Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH, Min DS
- KMID: 756211
- Exp Mol Med.
- 2009 Sep;41(9):678-685.
- doi: 10.3858/emm.2009.41.9.074
In spite of the importance of phospholipase D (PLD) in cell proliferation and tumorigenesis, little is known about the molecules regulating PLD expression. Thus, identification of small molecules inhibiting PLD... -
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- Gene network and canonical pathway analysis in prostate cancer: a microarray study
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Savli H, Szendroi A, Romics I, Nagy B
- KMID: 1052940
- Exp Mol Med.
- 2008 Apr;40(2):176-185.
- doi: 10.3858/emm.2008.40.2.176
The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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