- Roles of Protein Arginine Methyltransferases in the Control of Glucose Metabolism
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Han HS, Choi D, Choi S, Koo SH
- KMID: 2384238
- Endocrinol Metab.
- 2014 Dec;29(4):435-440.
- doi: 10.3803/EnM.2014.29.4.435
Glucose homeostasis is tightly controlled by the regulation of glucose production in the liver and glucose uptake into peripheral tissues, such as skeletal muscle and adipose tissue. Under prolonged fasting,... -
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- Protein Methylation and Interaction with the Antiproliferative Gene, BTG2(/TIS21/Pc3)
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Paik WK, Kim S, Lim IK
- KMID: 2386454
- Yonsei Med J.
- 2014 Mar;55(2):292-303.
The last one and half a decade witnessed an outstanding re-emergence of attention and remarkable progress in the field of protein methylation. In the present article, we describe the early... -
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- Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review
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Kim H, Kang JS, Jeong HJ
- KMID: 2470434
- Precis Future Med.
- 2019 Dec;3(4):139-145.
- doi: 10.23838/pfm.2019.00107
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated... -
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- Identification of Protein Arginine Methyltransferase 5 as a Regulator for Encystation of Acanthamoeba
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Moon EK, Hong Y, Chung DI, Goo YK, Kong HH
- KMID: 2164009
- Korean J Parasitol.
- 2016 Apr;54(2):133-138.
- doi: 10.3347/kjp.2016.54.2.133
Encystation is an essential process for Acanthamoeba survival under nutrient-limiting conditions and exposure to drugs. The expression of several genes has been observed to increase or decrease during encystation. Epigenetic... -
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- Writing, erasing and reading histone lysine methylations
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Hyun K, Jeon J, Park K, Kim J
- KMID: 2382715
- Exp Mol Med.
- 2017 Apr;49(4):e324.
- doi: 10.1038/emm.2017.11
Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their... -
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- ArmA and RmtB Were the Predominant 16S RMTase Genes Responsible for Aminoglycoside-resistant Isolates in Korea
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Lee TH, Hwang JH, Lee WK, Shin MK, Woo HR, Chung KM, Lee CS
- KMID: 2422087
- J Korean Med Sci.
- 2018 Oct;33(42):e262.
- doi: 10.3346/jkms.2018.33.e262
Pathogenic gram-negatives that produce 16S ribosomal RNA methyltransferases (16S RMTases) have already been distributed all over the world. To investigate the predominance of aminoglycoside resistance associated with 16S RMTases in... -
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- Epigenetic Changes (Aberrant DNA Methylation) in Colorectal Neoplasia
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Kim YS, Deng G
- KMID: 2284042
- Gut Liver.
- 2007 Jun;1(1):1-11.
Both genetic and epigenetic events have been implicated in the stepwise histological progression involving adenoma-carcinoma and hyperplastic polyp/serrated adenoma-carcinoma sequences in the development of colorectal cancer. Genetic changes have been... -
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- Protein methylation in cellular proliferation and differentiation: Non-histone nuclear methyl acceptor protein(s) during 3'-methyl-4-dimethylaminoazobenzeneinduced hepatocarcinogenesis
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Paik MK, Han YJ, Hong JH, Kim JS, Suh KS, Yoon SJ
- KMID: 2128624
- Exp Mol Med.
- 1997 Mar;29(1):35-43.
An accelerating effect of methyl-deficient diet (MDD) on hepatocarcinogenesis and methylation pattern of nuclear protein(s) by S-adenosylmethionine: protein arginine N-methyltransferase (protein methylase I, PM-I) have been studied with 3'-methyl-4-dimethyl- aminoazobenzene(MeDAB)-treated... -
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- Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins
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Mirza S, Sharma G, Parshad R, Gupta SD, Pandya P, Ralhan R
- KMID: 2374541
- J Breast Cancer.
- 2013 Mar;16(1):23-31.
PURPOSE: The DNA methylation mediated by specific DNA methyltransferases (DNMTs), results in the epigenetic silencing of multiple genes which are implicated in human breast cancer. We hypothesized that the natural... -
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- The Emergence of the 16S rRNA Methyltransferase RmtB in a Multidrug-Resistant Serratia marcescens Isolate in China
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Ma XJ, Yang HF, Liu YY, Mei Q, Ye Y, Li HR, Cheng J, Li JB
- KMID: 2363172
- Ann Lab Med.
- 2015 Jan;35(1):172-174.
- doi: 10.3343/alm.2015.35.1.172
No abstract available. -
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- Isolation of MLL1 Inhibitory RNA Aptamers
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Ul-Haq A, Jin ML, Jeong KW, Kim HM, Chun KH
- KMID: 2442012
- Biomol Ther.
- 2019 Feb;27(2):201-209.
- doi: 10.4062/biomolther.2018.157
Mixed lineage leukemia proteins (MLL) are the key histone lysine methyltransferases that regulate expression of diverse genes. Aberrant activation of MLL promotes leukemia as well as solid tumors in humans,... -
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- Enzymology of Protein Methylation
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Paik WK, Kim S
- KMID: 693029
- Yonsei Med J.
- 1986 Sep;27(3):159-177.
- doi: 10.3349/ymj.1986.27.3.159
No abstract available. -
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- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells
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Kim D, Kim Y, Kim Y
- KMID: 2468812
- J Cancer Prev.
- 2019 Dec;24(4):224-232.
- doi: 10.15430/JCP.2019.24.4.224
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have... -
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- Dissemination of Plasmid-mediated qnr, aac(6')-Ib-cr, and qepA Genes Among 16S rRNA Methylase Producing Enterobacteriaceae in Korea
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Kang HY, Tamang MD, Seol SY, Kim J
- KMID: 1474160
- J Bacteriol Virol.
- 2009 Sep;39(3):173-182.
- doi: 10.4167/jbv.2009.39.3.173
Plasmid-mediated quinolone resistance (PMQR) genes: qnr, aac(6')-Ib-cr, and qepA were investigated among 153 armA and 51 rmtB-positive transconjugants and their 204 clinical isolates of Enterobacteriaceae. Overall, qnrB4 and aac(6')-Ib-cr genes... -
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- Identification and Characterization of Protein Arginine Methyltransferase 1 in Acanthamoeba castellanii
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Moon EK, Kong HH, Hong Y, Lee HA, Quan FS
- KMID: 2379411
- Korean J Parasitol.
- 2017 Apr;55(2):109-114.
- doi: 10.3347/kjp.2017.55.2.109
Protein arginine methyltransferase (PRMT) is an important epigenetic regulator in eukaryotic cells. During encystation, an essential process for Acanthamoeba survival, the expression of a lot of genes involved in the... -
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- Inhibitors of DNA methylation support TGF-β1-induced IL11 expression in gingival fibroblasts
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Sufaru IG, Beikircher G, Weinhaeusel A, Gruber R
- KMID: 2377741
- J Periodontal Implant Sci.
- 2017 Apr;47(2):66-76.
- doi: 10.5051/jpis.2017.47.2.66
PURPOSE: Oral wound healing requires gingival fibroblasts to respond to local growth factors. Epigenetic silencing through DNA methylation can potentially decrease the responsiveness of gingival fibroblasts to local growth factors.... -
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- 6-Thioguanine-Induced Hepatic Sinusoidal Obstruction Syndrome in a Leukemic Child with TPMT Heterozygote
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Kwon YJ, Yoon JH, Park JA, Bang JS, Park BK, Choi JI, Kong SY, Park HJ
- KMID: 2049280
- Clin Pediatr Hematol Oncol.
- 2012 Oct;19(2):109-113.
Hepatic sinusoidal obstruction syndrome (hSOS) can be developed as a common complication after hematopoietic stem cell transplantation (HSCT), and rarely after 6-thioguanine-based chemotherapy without HSCT. A four-year-old boy with heterozygotic... -
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- Genetic Polymorphism of Thiopurine Methyltransferase in Children with Acute Lymphoblastic Leukemia
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Cho HG, Baek HJ, Han DK, Bae SY, Kook H, Hwang TJ
- KMID: 1483074
- Clin Pediatr Hematol Oncol.
- 2008 Apr;15(1):1-9.
Purpose: 6-mercaptopurine (6-MP) is a very important drug in pediatric patients for the maintenance treatment of acute lymphoblastic leukemia (ALL). 6-MP is catabolized by thiopurine methyltransferase (TPMT). TPMT activity, one... -
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- The Genetic Characteristics of Multidrug-resistant Acinetobacter baumannii Coproducing 16S rRNA Methylase armA and Carbapenemase OXA-23
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Lim J, Cho HH, Kim S, Kim J, Kwon KC, Park JW, Koo SH
- KMID: 1782700
- J Bacteriol Virol.
- 2013 Mar;43(1):27-36.
- doi: 10.4167/jbv.2013.43.1.27
Acinetobacter baumannii is a gram-negative organism reported worldwide as a cause of health-care associated infections. Due to its increasing drug resistance, several studies on coproduction of armA and carbapenemase in... -
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- Differences in the Adverse Effects of Azathioprine between Inflammatory Bowel Disease and Autoimmune Hepatitis in Korean Patients
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Lee YJ, Choi WY, Park KS, Kim YJ, Cho KB, Kim ES, Jang BK, Chung WJ, Hwang JS
- KMID: 2160667
- Korean J Gastroenterol.
- 2014 Dec;64(6):348-355.
- doi: 10.4166/kjg.2014.64.6.348
BACKGROUND/AIMS: Azathioprine (AZA) has been widely used in the therapy of inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH). However, studies evaluating the adverse effects of AZA in these two... -
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