J Korean Med Sci.
2018 Oct;33(42):e262. 10.3346/jkms.2018.33.e262.
ArmA and RmtB Were the Predominant 16S RMTase Genes Responsible for Aminoglycoside-resistant Isolates in Korea
- Affiliations
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- 1Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, Korea. kmin@jbnu.ac.kr
- 2Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Korea.
- 3Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. lcsmd@jbnu.ac.kr
- 4Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
- 5Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, Korea.
- 6Department of New Biology, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Korea.
- KMID: 2422087
- DOI: http://doi.org/10.3346/jkms.2018.33.e262
Abstract
- Pathogenic gram-negatives that produce 16S ribosomal RNA methyltransferases (16S RMTases) have already been distributed all over the world. To investigate the predominance of aminoglycoside resistance associated with 16S RMTases in Korea, we collected a total of 222 amikacin resistant Gram-negative clinical isolates from patient specimens between 1999 and 2015 from three hospital banks across Korea. ArmA and rmtB were the predominant 16S RMTase genes responsible for aminoglycoside-resistant isolates circulating in Korean community settings although only one rmtA-producing isolate was detected in 2006.
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