- Microarray Data Analysis of Perturbed Pathways in Breast Cancer Tissues
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Kim C, Choi J, Yoon S
- KMID: 2166421
- Genomics Inform.
- 2008 Dec;6(4):210-222.
Due to the polygenic nature of cancer, it is believed that breast cancer is caused by the perturbation of multiple genes and their complex interactions, which contribute to the wide... -
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- Vitamin D and its effects on cardiovascular diseases: a comprehensive review
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Pérez-Hernández N, Aptilon-Duque G, Nostroza-Hernández MC, Vargas-Alarcón G, RodrÃguez-Pérez JM, Blachman-Braun R
- KMID: 2382851
- Korean J Intern Med.
- 2016 Nov;31(6):1018-1029.
- doi: 10.3904/kjim.2015.224
Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that... -
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- A Metabolic Pathway Drawing Algorithm for Reducing the Number of Edge Crossings
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Song EH, Kim MK, Lee SH
- KMID: 1512146
- Genomics Inform.
- 2006 Sep;4(3):118-124.
For the direct understanding of flow, pathway data are usually represented as directed graphs in biological journals and texts. Databases of metabolic pathways or signal transduction pathways inevitably contain these... -
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- J2.5dPathway: A 2.5D Visualization Tool to Display Selected Nodes in Biological Pathways, in Parallel Planes
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Ham SI, Song EH, Yang SD, Thong CT, Rhie A, Galbadrakh B, Lee KE, Park HS, Lee SH
- KMID: 1469578
- Genomics Inform.
- 2009 Sep;7(3):171-174.
The characteristics of metabolic pathways make them particularly amenable to layered graph drawing methods. This paper presents a visual Java-based tool for drawing and annotating biological pathways in twoand- a-half... -
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- Regulation of glucose metabolism from a liver-centric perspective
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Han HS, Kang G, Kim JS, Choi BH, Koo SH
- KMID: 2361505
- Exp Mol Med.
- 2016 Mar;48(3):e218.
- doi: 10.1038/emm.2015.122
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual's health. The liver has a major role in the control of glucose... -
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- The BIOWAY System: A Data Warehouse for Generalized Representation & Visualization of Bio-Pathways
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Kim MK, Seol YJ, Lee SH, Song EH, Lee HI, Ahn CS, Choi EC, Park HS
- KMID: 1515377
- Genomics Inform.
- 2004 Dec;2(4):191-194.
Exponentially increasing biopathway data in recent years provide us with means to elucidate the large-scale modular organization of the cell. Given the existing information on metabolic and regulatory networks, inferring... -
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- J2dpathway: A Global Metabolic Pathway Viewer with Node-Abstracting Features
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Song EH, Ham SI, Yang SD, Rhie A, Park HS, Lee SH
- KMID: 2166341
- Genomics Inform.
- 2008 Jun;6(2):68-71.
The static approach of representing metabolic pathway diagrams offers no flexibility. Thus, many systems adopt automatic graph layout techniques to visualize the topological architecture of pathways. There are weaknesses, however,... -
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- Targeting Lipid Metabolic Reprogramming as Anticancer Therapeutics
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Cha JY, Lee HJ
- KMID: 2367557
- J Cancer Prev.
- 2016 Dec;21(4):209-215.
- doi: 10.15430/JCP.2016.21.4.209
Cancer cells rewire their metabolism to satisfy the demands of growth and survival, and this metabolic reprogramming has been recognized as an emerging hallmark of cancer. Lipid metabolism is pivotal... -
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- In silico analysis of putative drug and vaccine targets of the metabolic pathways of Actinobacillus pleuropneumoniae using a subtractive/comparative genomics approach
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Birhanu BT, Lee SJ, Park NH, Song JB, Park SC
- KMID: 2407618
- J Vet Sci.
- 2018 Mar;19(2):188-199.
- doi: 10.4142/jvs.2018.19.2.188
Actinobacillus pleuropneumoniae is a Gram-negative bacterium that resides in the respiratory tract of pigs and causes porcine respiratory disease complex, which leads to significant losses in the pig industry worldwide.... -
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- The Immune Landscape in Nonalcoholic Steatohepatitis
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Narayanan , Surette FA, Hahn YS
- KMID: 2299788
- Immune Netw.
- 2016 Jun;16(3):147-158.
- doi: 10.4110/in.2016.16.3.147
The liver lies at the intersection of multiple metabolic pathways and consequently plays a central role in lipid metabolism. Pathological disturbances in hepatic lipid metabolism are characteristic of chronic metabolic... -
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- Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
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Jha MK, Suk K
- KMID: 2048476
- Brain Tumor Res Treat.
- 2013 Oct;1(2):57-63.
- doi: 10.14791/btrt.2013.1.2.57
Metabolic aberrations in the form of altered flux through key metabolic pathways are the major hallmarks of several life-threatening malignancies including malignant gliomas. These adaptations play an important role in... -
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- Metabolic Signaling to Epigenetic Alterations in Cancer
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Kim JA, Yeom YI
- KMID: 2400816
- Biomol Ther.
- 2018 Jan;26(1):69-80.
- doi: 10.4062/biomolther.2017.185
Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects:... -
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- Genome-Wide Association Study of Metabolic Syndrome in Koreans
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Jeong SW, Chung M, Park SJ, Cho SB, Hong KW
- KMID: 2391495
- Genomics Inform.
- 2014 Dec;12(4):187-194.
- doi: 10.5808/GI.2014.12.4.187
Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we... -
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- ROS homeostasis and metabolism: a critical liaison for cancer therapy
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Kim J, Kim J, Bae JS
- KMID: 2362293
- Exp Mol Med.
- 2016 Nov;48(11):e269.
- doi: 10.1038/emm.2016.119
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can... -
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- AMPK activators: mechanisms of action and physiological activities
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Kim J, Yang G, Kim Y, Kim J, Ha J
- KMID: 2361511
- Exp Mol Med.
- 2016 Apr;48(4):e224.
- doi: 10.1038/emm.2016.16
AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of... -
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- The Relationship between Mitochondria and NLRP3 Inflammasome
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Lee HA, Na HS, Chung J
- KMID: 2394576
- Int J Oral Biol.
- 2017 Sep;42(3):85-90.
- doi: 10.11620/IJOB.2017.42.3.085
Mitochondria participate in various intracellular metabolic pathways such as generating intracellular ATP, synthesizing several essential molecules, regulating calcium homeostasis, and producing the cell's reactive oxygen species (ROS). Emerging studies have... -
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- Apoptosis of Fas Expressed Target Cells Induced by Cytotoxic T Lymphocytes
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Kim SH, Kim SY
- KMID: 1548225
- Korean J Immunol.
- 1997 Jun;19(2):245-262.
Cytotoxic T lymphocytes (CTL) playing an important role in e cell-mediated immune response kill the target cells by the special contact-dependent mechanism. It has been known that CTL and NK... -
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- Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology
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Sassa T, Kihara A
- KMID: 2170646
- Biomol Ther.
- 2014 Mar;22(2):83-92.
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found... -
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- Role of Peroxisome Proliferator-Activated Receptor alpha in Diabetic Nephropathy
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Chung S, Park CW
- KMID: 2281638
- Diabetes Metab J.
- 2011 Aug;35(4):327-336.
- doi: 10.4093/dmj.2011.35.4.327
With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process.... -
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- New therapeutic agents in diabetic nephropathy
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Kim Y, Park CW
- KMID: 2365975
- Korean J Intern Med.
- 2017 Jan;32(1):11-25.
- doi: 10.3904/kjim.2016.174
Studies investigating diabetic nephropathy (DN) have mostly focused on interpreting the pathologic molecular mechanisms of DN, which may provide valuable tools for early diagnosis and prevention of disease onset and... -
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