- In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood
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Park KS, Lee YS, Kang KS
- KMID: 1089481
- J Vet Sci.
- 2006 Dec;7(4):343-348.
- doi: 10.4142/jvs.2006.7.4.343
Mesenchymal stem cells (MSCs) have the capabilities for self-renewal and differentiation into cells with the phenotypes of bone, cartilage, neurons and fat cells. These features of MSCs have attracted the... -
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- Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells
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Kwak DH, Yu K, Kim SM, Lee DH, Kim SM, Jung JU, Seo JW, Kim N, Lee SK, Jung KY, You H, Kim HA, Choo YK
- KMID: 1115945
- Exp Mol Med.
- 2006 Dec;38(6):668-676.
Stem cells are used for the investigation of developmental processes at both cellular and organism levels and offer tremendous potentials for clinical applications as an unlimited source for transplantation. Gangliosides,... -
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- Clinical Application of Marrow Mesenchymal Stem Cells for Hard Tissue Repair
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Ohgushi H, Kitamura S, Kotobuki N, Hirose M, Machida H, Muraki K, Takakura Y
- KMID: 1726148
- Yonsei Med J.
- 2004 Jun;45(Suppl):S61-S67.
- doi: 10.3349/ymj.2004.45.Suppl.61
Human marrow mesenchymal stem cells were cultured in a medium containing glycerophosphate, ascorbic acid, and dexamethasone (Dex) on alumina ceramic discs and on tissue culture polystyrene (TCPS) dishes. Cell proliferation... -
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- Comparison of Phenotypic Characterization between "Alginate Bead" and "Pellet" Culture Systems as Chondrogenic Differentiation Models for Human Mesenchymal Stem Cells
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Yang IH, Kim SH, Kim YH, Sun HJ, Kim SJ, Lee JW
- KMID: 1103913
- Yonsei Med J.
- 2004 Oct;45(5):891-900.
- doi: 10.3349/ymj.2004.45.5.891
Chondrogenesis involves the recruitment of mesenchymal cells to differentiate into chondroblasts, and also the cells must synthesize a cartilage-specific extracellular matrix. There were two representative culture systems that promoted the... -
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- Stemness Evaluation of Mesenchymal Stem Cells from Placentas According to Developmental Stage: Comparison to Those from Adult Bone Marrow
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Sung HJ, Hong SC, Yoo JH, Oh JH, Shin HJ, Choi IY, Ahn KH, Kim SH, Park Y, Kim BS
- KMID: 2157843
- J Korean Med Sci.
- 2010 Oct;25(10):1418-1426.
- doi: 10.3346/jkms.2010.25.10.1418
This study was done to evaluate the stemness of human mesenchymal stem cells (hMSCs) derived from placenta according to the development stage and to compare the results to those from... -
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- Cotransplanted Bone Marrow Derived Mesenchymal Stem Cells (MSC) Enhanced Engraftment of Hematopoietic Stem Cells in a MSC-dose Dependent Manner in NOD/SCID Mice
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Kim DH, Yoo KH, Yim YS, Choi J, Lee SH, Jung HL, Sung KW, Yang SE, Oh WI, Yang YS, Kim SH, Choi SY, Koo HH
- KMID: 1713108
- J Korean Med Sci.
- 2006 Dec;21(6):1000-1004.
- doi: 10.3346/jkms.2006.21.6.1000
Transplantation of marrow-derived mesenchymal stem cells (MSCs), expanded by culture in addition to whole bone marrow, has been shown to enhance engraftment of human hematopoietic stem cells (HSCs). Our hypothesis... -
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- Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells
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Lee J, Lee CG, Lee KW, Lee CW
- KMID: 1099864
- Exp Mol Med.
- 2009 Dec;41(12):873-879.
- doi: 10.3858/emm.2009.41.12.093
BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of the chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and... -
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- Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells
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Seo MS, Jeong YH, Park JR, Park SB, Rho KH, Kim HS, Yu KR, Lee SH, Jung JW, Lee YS, Kang KS
- KMID: 1726916
- J Vet Sci.
- 2009 Sep;10(3):181-187.
- doi: 10.4142/jvs.2009.10.3.181
Human umbilical cord blood-derived mesenchymal stem cells (MSCs) are known to possess the potential for multiple differentiations abilities in vitro and in vivo. In canine system, studying stem cell therapy... -
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- Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor
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Kim CH, Lee JH, Won JH, Cho MK
- KMID: 1785956
- J Korean Med Sci.
- 2011 Jun;26(6):726-733.
- doi: 10.3346/jkms.2011.26.6.726
We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of... -
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- Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells
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Kim B, Yoon BS, Moon JH, Kim J, Jun EK, Lee JH, Kim JS, Baik CS, Kim A, Whang KY, You S
- KMID: 1120139
- Exp Mol Med.
- 2012 Jan;44(1):26-35.
- doi: 10.3858/emm.2012.44.1.002
Recent evidence has suggested that human skin fibroblasts may represent a novel source of therapeutic stem cells. In this study, we report a 3-stage method to induce the differentiation of... -
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- Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cells
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Jin GZ, Yin XJ, Yu XF, Cho SJ, Lee HS, Lee HJ, Kong IK
- KMID: 1106218
- J Vet Sci.
- 2007 Dec;8(4):377-382.
- doi: 10.4142/jvs.2007.8.4.377
Mesenchymal stem cells (MSCs) secrete a variety of neuroregulatory molecules, such as nerve growth factor, brain-derived neurotrophic factor, and glial cell-derived neurotrophic factor, which upregulate tyrosine hydroxylase (TH) gene expression... -
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- Ectopic expression of cyclooxygenase-2-induced dedifferentiation in articular chondrocytes
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Lee WK, Yu SM, Cheong SW, Sonn JK, Kim SJ
- KMID: 1072952
- Exp Mol Med.
- 2008 Dec;40(6):721-727.
- doi: 10.3858/emm.2008.40.6.721
Cyclooxygenase-2 (COX-2) is known to modulate bone metabolism, including bone formation and resorption. Because cartilage serves as a template for endochondral bone formation and because cartilage development is initiated by... -
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- Transplantation of Neural Differentiated Human Mesenchymal Stem Cells into the Cochlea of an Auditory-neuropathy Guinea Pig Model
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Cho YB, Cho HH, Jang S, Jeong HS, Park JS
- KMID: 1777878
- J Korean Med Sci.
- 2011 Apr;26(4):492-498.
- doi: 10.3346/jkms.2011.26.4.492
The aim of this study was to determine the effects of transplanted neural differentiated human mesenchymal stem cells (hMSCs) in a guinea pig model of auditory neuropathy. In this study,... -
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- Thromboxane A2 modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells
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Yun DH, Song HY, Lee MJ, Kim MR, Kim MY, Lee JS, Kim JH
- KMID: 756282
- Exp Mol Med.
- 2009 Jan;41(1):17-24.
- doi: 10.3858/emm.2009.41.1.003
Prostanoid metabolites are key mediators in inflammatory responses, and accumulating evidence suggests that mesenchymal stem cells (MSCs) can be recruited to injured or inflamed tissues. In the present study, we... -
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- Co-transplantation of Human Mesenchymal Stem Cells Promotes Human CD34+ Cells Engraftment in a Dose-dependent Fashion in NOD/SCID Mice
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Park SK, Won JH, Kim HJ, Bae SB, Kim CK, Lee KT, Lee NS, Lee YK, Jeong DC, Chung NG, Kim HS, Hong DS, Park HS
- KMID: 1778346
- J Korean Med Sci.
- 2007 Jun;22(3):412-419.
- doi: 10.3346/jkms.2007.22.3.412
Mesenchymal stem cells (MSCs) have recently been identified and characterized in humans. Moreover, MSC secrete cytokines that can support hematopoietic progenitor growth. In the present study, we evaluated whether the... -
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- Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells
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Kim KH, Kim YM, Lee MJ, Ko HC, Kim MB, Kim JH
- KMID: 1120134
- Exp Mol Med.
- 2012 Feb;44(2):159-166.
- doi: 10.3858/emm.2012.44.2.011
Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle-like cells expressing alpha-smooth muscle actin (alpha-SMA) via transforming growth factor-beta1/Smad2- and RhoA/Rho kinase-dependent mechanisms. 3-Hydroxy-3-methylglutaryl-coenzyme... -
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- Establishment of Efficacy and Safety Assessment of Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in a Nude Rat Femoral Segmental Defect Model
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Choi HJ, Kim JM, Kwon E, Che JH, Lee JI, Cho SR, Kang SK, Ra JC, Kang BC
- KMID: 1777877
- J Korean Med Sci.
- 2011 Apr;26(4):482-491.
- doi: 10.3346/jkms.2011.26.4.482
Human adipose tissue-derived mesenchymal stem cell (hATMSC) have emerged as a potentially powerful tool for bone repair, but an appropriate evaluation system has not been established. The purpose of this... -
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- Effects of Polycaprolactone-Tricalcium Phosphate, Recombinant Human Bone Morphogenetic Protein-2 and Dog Mesenchymal Stem Cells on Bone Formation: Pilot Study in Dogs
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Kim SJ, Kim MR, Oh JS, Han I, Shin SW
- KMID: 1777098
- Yonsei Med J.
- 2009 Dec;50(6):825-831.
- doi: 10.3349/ymj.2009.50.6.825
PURPOSE: The aim of this study was to evaluate the survival, proliferation, and bone formation of dog mesenchymal stem cells (dMSCs) in the graft material by using Polycaprolactone-tricalcium phosphate (PCL-TCP),... -
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- Individual Variation in Growth Factor Concentrations in Platelet-rich Plasma and Its Influence on Human Mesenchymal Stem Cells
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Cho HS, Song IH, Park SY, Sung MC, Ahn MW, Song KE
- KMID: 1735857
- Korean J Lab Med.
- 2011 Jul;31(3):212-218.
- doi: 10.3343/kjlm.2011.31.3.212
BACKGROUND: The objective of this study was to explore whether individual variations in the concentration of growth factors (GFs) influence the biologic effects of platelet-rich plasma (PRP) on human mesenchymal... -
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- Chondrogenic Differentiation of Mesenchymal Stem Cells and Its Clinical Applications
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Lee JW, Kim YH, Kim SH, Han SH, Hahn SB
- KMID: 1726144
- Yonsei Med J.
- 2004 Jun;45(Suppl):S41-S47.
- doi: 10.3349/ymj.2004.45.Suppl.41
Tissue engineering has the potential to provide cartilaginous constructs capable of restoring the normal function of native articular cartilage following joint injury or degradation. One approach to functional tissue engineering... -
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