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The Effect of Strychnine on Membrane Properties of Spinal Motoneurons in the Cat

Lee KC, Klee MR, Lee HJ

Strychnine (Stry.) has been used, as an instrument for studies of experimental epilepsy, though its precise mode of action has remained obscure. One mechanism of action was partially clarified in...
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CFTR, a rectifying, non-rectifying anion channel?

Quinton PM, Reddy MM

No abstract available.
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Effects of vanadate on vascular contractility and membrane potential in the rabbit aorta

Chung SM, Ahn DS, Seok HS, Jeong Y, Kang BS

Isolated rabbit aortic ring with intact endothelial cell preparations precontracted with NE (10(-7) M) were relaxed by vanadate in a dose dependent manner (from 0.2 to 2 mM). Application of...
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Effects of Mixed Herbal Extracts from Parched Puerariae Radix, Gingered Magnoliae Cortex, Glycyrrhizae Radix and Euphorbiae Radix (KIOM-79) on Cardiac Ion Channels and Action Potentials

Park SJ, Choi KS, Shin DH, Kim JS, Jang DS, Youm JB, Choe H, Earm YE, Kim SJ

KIOM-79, a mixture of ethanol extracts from four herbs (parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix), has been developed for the potential therapeutic application to diabetic...
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Methionine Enhances the Contractile Activity of Human Colon Circular Smooth Muscle In Vitro

Choe EK, Moon JS, Park KJ

Effective drug to manage constipation has been unsatisfactory. We sought to determine whether methionine has effect on the human colon. Human colon tissues were obtained from the specimens of colon...
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Mechanism of Low K+-induced Depolarization in Mammalian Cardiac Muscle

Ahn DS, Lee SI, Kang DH

The membrane permeability to potassium at a resting state is greater than to any other ions and the maintenance of resting membrane potential is largely dependent on K+ concentration of...
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Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release

Kwon KB, Kim EK, Shin BC, Seo EA, Yang JY, Ryu DG

  • KMID: 1097256
  • Exp Mol Med.
  • 2003 Apr;35(2):91-97.
Herba houttuyniae has been used as a constituent of herval medicine prescriptions for the treatment of inflammation, cancer, and other diseases. In the present study, we investigated the cellular effects...
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Effects of Vanadate on Cellular Ca2+ Movements in Guinea Pig Papillary Muscles

Suh CK, Park SR, Ahn DS, Paik KS

The effects of vanadate on cellular Ca2+ movements across the sarcolemma of cardiac muscle cells were investigated by measuring the intracellular and extracellular Ca2+ activities of guinea pig papillary muscle...
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Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells

Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR

  • KMID: 1110128
  • Exp Mol Med.
  • 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis...
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Changes in Inward Rectifier K+ Channels in Hepatic Stellate Cells During Primary Culture

Lee DH, Kong ID, Lee JW, Park KS

PURPOSE: This study examined the expression and function of inward rectifier K+ channels in cultured rat hepatic stellate cells (HSC). MATERIALS AND METHODS: The expression of inward rectifier K+ channels...
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Fatty acids directly increase the activity of Ca(2+)-activated K+ channels in rabbit coronary smooth muscle cells

Ahn DS, Kim YB, Lee YH, Kang BS, Kang DH

The large conductance Ca2+ activated K+ channel (BK channel) has been considered to play an important role in the excitability and contractility of vascular smooth muscle cells. Activation of the...
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Characterization of Pacemaking Currents in Cultured Interstitial Cells of Cajal from Mice Small Intestine

Chang SJ, Cho ET, Heo GS, Park CG, Kim MW, Chang IY, Shin MK, Cha KH, Yeum CH, Jun JY

  • KMID: 772533
  • Korean J Gastroenterol.
  • 2003 Aug;42(2):121-127.
BACKGROUND/AIMS: Gastrointestinal motility is initiated by the periodic generation of slow waves. Interstitial cells of Cajal (ICC) are pacemaker cells that generate slow waves and drive spontaneous mechanical contractions...
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Ca2+-activated K+ Current in Freshly Isolated c-Kit Positive Cells in Guinea-pig Stomach

Kim YC, Suzuki H, Xu WX, Choi W, Kim SH, Lee SJ

This study was designed to isolate Ca2+-activated K+ current (IKCa) and elucidate its physiological significance in freshly isolated interstitial cells of Cajal (ICCs) of guinea-pig stomach. Single ICC was freshly...
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Characteristics of Potassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Rat

Lee KI, Kong ID, Baik SK, Kim HS, Lee DK, Kwon SO, Chun BG

Hepatic stellate cells (HSCs) are known to play a role in the pathogenesis of the increased intrahepatic vascular resistance found in chronic liver diseases. The aim of this study was...
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