- Critics on "Adjunctive Memantine Therapy for Cognitive Impairment in Chronic Schizophrenia: A Placebo-Controlled Pilot Study"
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Pae CU
- KMID: 2316254
- Psychiatry Investig.
- 2013 Mar;10(1):98-99.
No abstract available. -
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- Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
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Uribe E, Landaeta J, Wix R, Eblen A
- KMID: 2165437
- Exp Neurobiol.
- 2013 Mar;22(1):18-22.
- doi: 10.5607/en.2013.22.1.18
The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an... -
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- Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia
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Kim TW, Kim DM, Park KH, Kim H
- KMID: 754312
- Korean J Ophthalmol.
- 2002 Jun;16(1):1-7.
- doi: 10.3341/kjo.2002.16.1.1
The purpose of this study was to evaluate the neuroprotective effect of memantine, a N-methyl-D-aspartate antagonist, in an experimental optic nerve ischemia. Endothelin-1 (ET-1) in a dosage of 0.1 microg/day... -
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- Neonatal Administration of Memantine Enhances Social Cognition in Adult Rats Subjected to Early Maternal Deprivation
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Uribe E, Sánchez-Mendoza E, Nieves N, Merchor G
- KMID: 2362829
- Exp Neurobiol.
- 2016 Dec;25(6):328-332.
- doi: 10.5607/en.2016.25.6.328
Schizophrenia is considered a neurodevelopmental disorder; however, all the available treatment options are used when the disease becomes clinically significant in adolescence or early adulthood. Using a developmental rat model... -
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- Memantine Induces NMDAR1-Mediated Autophagic Cell Death in Malignant Glioma Cells
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Yoon WS, Yeom MY, Kang ES, Chung YA, Chung DS, Jeun SS
- KMID: 2374873
- J Korean Neurosurg Soc.
- 2017 Feb;60(2):130-137.
- doi: 10.3340/jkns.2016.0101.006
OBJECTIVE: Autophagy is one of the key responses of cells to programmed cell death. Memantine, an approved anti-dementia drug, has an antiproliferative effect on cancer cells but the mechanism is... -
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- Oral Administration of Memantine Prolongs Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
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Joo IS, Hwang DH, Seok JI, Shin SK, Kim SU
- KMID: 1808551
- J Clin Neurol.
- 2007 Dec;3(4):181-186.
- doi: 10.3988/jcn.2007.3.4.181
BACKGROUND AND PURPOSE: N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and oxidative stress have been implicated in the etiology of amyotrophic lateral sclerosis (ALS). Memantine is a low-affinity, noncompetitive NMDA receptor antagonist that may... -
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- Adjunctive Memantine Therapy for Cognitive Impairment in Chronic Schizophrenia: A Placebo-Controlled Pilot Study
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Lee JG, Lee SW, Lee BJ, Park SW, Kim GM, Kim YH
- KMID: 2316178
- Psychiatry Investig.
- 2012 Jun;9(2):166-173.
OBJECTIVE: To investigate the effects of memantine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on cognitive impairments in patients with chronic schizophrenia. METHODS: A 12-week, placebo-controlled trial was conducted to determine the effectiveness... -
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- Drug Therapy for Alzheimer's Disease
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Suh GH
- KMID: 2184855
- J Korean Med Assoc.
- 2007 Apr;50(4):369-374.
- doi: 10.5124/jkma.2007.50.4.369
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD afflicts 0.3 to 0.5 million people in Korea, and the number is projected to increase to... -
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- A 10-Week Memantine Treatment in Bipolar Depression: A Case Report. Focus on Depressive Symptomatology, Cognitive Parameters and Quality of Life
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Strzelecki D, Tabaszewska A, Barszcz Z, Jozefowicz O, Kropiwnicki P, Rabe-Jablonska J
- KMID: 2316321
- Psychiatry Investig.
- 2013 Dec;10(4):421-424.
Memantine and other glutamatergic agents have been currently investigated in some off-label indications due to glutamatergic involvement in several psychoneurological disorders. We assumed that memantine similarly to ketamine may positively... -
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- The Effect of Memantine on Experimentally Gentamicin Induced Vestibulotoxicity in Guinea Pigs
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Park CH, Kim EH, Kim SI, Rha KS, Park YH
- KMID: 1455712
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Feb;53(2):77-83.
- doi: 10.3342/kjorl-hns.2010.53.2.77
BACKGROUND AND OBJECTIVES: In general, aminoglycosides are known to cause ototoxicity through the glutamate induced nitric oxide production. The N-methyl-D-aspartate (NMDA) related glutamate receptors have a pivotal role in aminoglycoside... -
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- Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
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Park BY, Park SH, Kim WM, Yoon MH, Lee HG
- KMID: 1767875
- Korean J Pain.
- 2010 Sep;23(3):179-185.
- doi: 10.3344/kjp.2010.23.3.179
BACKGROUND: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine... -
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- Clinical Efficacy and Safety of Memantine in Patients with Moderate to Severe Dementia
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Ahn IS, Hwang TY, Kim S, Yun JH, Song M, Chung J, Kim DK
- KMID: 2286723
- Korean J Psychopharmacol.
- 2007 May;18(3):163-170.
OBJECTIVE: This study examined the efficacy and safety of memantine-an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist-in the treatment of moderate-to-severe dementia. METHODS: Forty-four patients with moderate-to-severe dementia received 20 mg of... -
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- Pharmacological Treatment in Alcohol-induced Cognitive Disorder
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Kim DJ, Joe KH
- KMID: 2340903
- J Korean Med Assoc.
- 2008 Jan;51(1):84-89.
Alcohol-induced cognitive disorder is a very severe problem in problem alcohol drinker and alcohol itself seems to be one of the main causalities in the development of senile dementia. However,... -
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- Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats
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Jung JY, Roh M, Ko KK, Jang HS, Lee SR, Ha JH, Jang IS, Lee HW, Lee MG
- KMID: 2011156
- Korean J Physiol Pharmacol.
- 2012 Aug;16(4):231-236.
- doi: 10.4196/kjpp.2012.16.4.231
We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal... -
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- Treatment Effects of Glutamate Antagonist for Tinnitus
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Choung YH, Park HJ, Song JW, Ryu SJ, Moon SK, Park K
- KMID: 2276063
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Nov;46(11):935-939.
BACKGROUND AND OBJECTIVES: Tinnitus is one of the most widespread disorders of the auditory system, affecting approximately 17% of the general population, with the frequency increasing to about 33% in... -
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- Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat
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Jang CH, Lee S, Park IY, Song A, Moon C, Cho GW
- KMID: 2458547
- Exp Neurobiol.
- 2019 Aug;28(4):495-503.
- doi: 10.5607/en.2019.28.4.495
Memantine, a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, suppresses the release of excessive levels of glutamate that may induce neuronal excitation. Here we investigated the effects of memantine on... -
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- Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease
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Zhou X, Wang L, Xiao W, Su Z, Zheng C, Zhang Z, Wang Y, Xu B, Yang X, Hoi MP
- KMID: 2451074
- Exp Neurobiol.
- 2019 Jun;28(3):390-403.
- doi: 10.5607/en.2019.28.3.390
Memantine is a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically approved for moderate-to-severe Alzheimer's disease (AD) to improve cognitive functions. There is no report about the proteomic alterations induced by memantine... -
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- Long-Term Efficacy of Memantine in Parkinson' Disease Dementia: An 18-Month Prospective Perfusion Single Photon Emission Computed Tomography Preliminary Study
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Jeong HS, Chung YA, Park JS, Song IU, Yang Y
- KMID: 2442854
- Dement Neurocogn Disord.
- 2016 Jun;15(2):43-48.
- doi: 10.12779/dnd.2016.15.2.43
BACKGROUND AND PURPOSE: Although the treatment efficacy of memantine in Parkinson's disease dementia (PDD) has been reported after several weeks of administration, the long-term effects on brain perfusion and clinical... -
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- Pharmacological Treatment of Alzheimer's Disease
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Lee JH
- KMID: 2053698
- Hanyang Med Rev.
- 2006 Feb;26(1):26-32.
The current treatment of Alzheimer's disease (AD) is based on symptomatic pharmacological therapy of cognitive decline and behavioural disturbance. A number of therapies have been investigated for the treatment and... -
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- Differntial effect of NMDA antagonists on D1 & D2 mediated rotation responses in 6- hydroxydopamine (6-OHDA) lesioned rat
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Hong KS, Kim KM, Yoon BW, Jeon BS
- KMID: 2342591
- J Korean Neurol Assoc.
- 1997 Feb;15(1):99-108.
BACKGROUND & OBJECTIVES: Glutamate is a major neurotrammitter in corticostriatal, subthalamopallidal, and subthalamonigral pathways and interacts with other neurotrammitters. The study was done to investigate the effects of NMDA blockade... -
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