- Regulation of Matrix Metalloproteinase 2 Expression by an Adenosine A1 Agonist in Trabecular Meshwork Cells
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Baek MJ, Kim KH, Kim JW
- KMID: 2422583
- J Korean Ophthalmol Soc.
- 2018 Oct;59(10):946-952.
- doi: 10.3341/jkos.2018.59.10.946
PURPOSE: We investigated the extent of adenosine A1 agonist-induced expression and regulation of matrix metalloproteinase 2 (MMP-2) synthesis in human trabecular meshwork cells (HTMC). METHODS: Primary HTMC cultures were exposed to... -
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- Expression of MMP-2, MT1-MMP, and TIMP-2 mRNA in Breast Carcinomas
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Kim DW, Jin SY, Lee DW
- KMID: 1979368
- Korean J Pathol.
- 2003 Dec;37(6):400-406.
BACKGROUND: The activation of proMMP-2 is induced by membrane type 1-matrix metalloproteinase (MT1-MMP), but inhibited by tissue inhibitors of matrix metalloproteinase type 2 (TIMP-2). This study was carried out to... -
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- Expression of Placental Gelatinases in Normal and Preeclamptic Pregnancy
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Roh JR, Oh WJ, CHoi JJ, Moon JS, Hwang JD, Yang SH
- KMID: 2261394
- Korean J Obstet Gynecol.
- 1999 Jun;42(6):1196-1200.
OBJECTIVES: The aim of this study was to compare activities of gelatinases and their regulators in normal and preeclamptic placenta tissue. METHODS: The activities of gelatinase A and B were... -
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- Membrane-type Matrix Metalloproteinase-1 Induced Invasive and Angiogenic Activities in Chick Chorioallantoic Membrane (CAM) Model
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Jeong JW, Sohn TK, Yu DY, Kim KW
- KMID: 2007126
- J Korean Cancer Assoc.
- 2001 Feb;33(1):49-55.
PURPOSE: Matrix metalloproteinases (MMPs) have been reported to play critical roles in the endothelial cell migration and matrix remodeling during angiogenic process. To investigate the roles of the membrane type... -
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- The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis
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Kim JB, Jung MH, Cho JY, Park JW, Suh JY, Lee JM
- KMID: 1783600
- J Periodontal Implant Sci.
- 2011 Jun;41(3):109-116.
- doi: 10.5051/jpis.2011.41.3.109
PURPOSE: The purpose of this study was to compare and quantify the expression of C-reactive protein (CRP), matrix metalloproteinase (MMP)-14, and tissue inhibitor of metalloproteinases (TIMP)-2 in gingival tissues of... -
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- Expression of MT1, 2, 3-MMP in invasive cervical cancer
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Moon HS, Sung SH, Chung HW, Kim SC
- KMID: 2077613
- Korean J Obstet Gynecol.
- 2006 Jun;49(6):1240-1248.
OBJECTIVE: Threre are several proteolytic enzymes such as Matrix Metalloproteinases (MMP), which are involved in tumor invasion and metastasis. The aim of this study was to determine the exprssion of... -
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- The Effects of Cyclosporine on the Generation of ROS and Extracellular Matrix Accumulation in Cultured Human Mesangial Cells
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Chae HK, Lee SJ, Kim HJ, Kong G, Kahng KW, Kang CM
- KMID: 1989887
- Korean J Nephrol.
- 2000 Nov;19(6):1024-1032.
OBJECTIVE: Treatment with cyclosporine(CsA) for a long-term period may induce renal glomerulosclersosis and interstitial fibrosis. Reactive oxygen species(ROS) seems to be involved in the process of glomerulosclersosis and interstitial fibrosis.... -
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- CD44 and MMP14 Expression Associated with WHO Grade of the Astrocytoma and the Prognostic Implications
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Myung J, Jang B, Park HS, Yon W, Lee HJ, Park SH
- KMID: 2277621
- Korean J Pathol.
- 2010 Feb;44(1):35-41.
BACKGROUND: CD44 is a cell surface receptor that has been implicated in tumor cell invasion and metastasis in a range of tumors of various organs, including breast, ovary, colon, lung,... -
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- Membrane activator of the 72 kDa type IV collagenase in malignant breast carcinoma patients: Expression of membrane-type 1-matrix metalloproteinase (MT1-MMP)
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Chai KJ, Lee HJ, Lee SJ, Lee KS
- KMID: 2128629
- Exp Mol Med.
- 1997 Mar;29(1):71-79.
In this study, we determined proMMP-2 activating capacity of membrane extract prepared from the tissue of invasive ductal carcinoma of breast by zymogram gel analysis. We compared the effect of... -
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- The Effect of Imiquimod on Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Malignant Melanoma Cell Invasion
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Jung JY, Kim HS, Roh MR, Roh HJ, Lee SY, Chung KY
- KMID: 2368158
- Ann Dermatol.
- 2014 Jun;26(3):363-373.
BACKGROUND: A number of reports have been published regarding the use of imiquimod for the treatment of melanoma in situ and metastatic melanoma. Essential steps in the process of melanoma... -
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- The Differences Between Cyclosporine and Tacrolimus in the Generation of ROS and Extracellular Matrix Accumulation in Primary Cultured Human Mesangial Cells
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Lee SK, Lee SJ, Kim HJ, Kong G, Kahng KW, Kang CM
- KMID: 2079155
- Korean J Nephrol.
- 2001 Mar;20(2):187-197.
OBJECTIVE: Cyclosporine(CsA) and tacrolimus, albeit different in structure, exert immunosuppressive effect by similar mechanism. Although most of clinical manifestations, including nephrotoxicity, are similar in the patients using these drugs, there... -
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- Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1
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Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CW
- KMID: 2155355
- Exp Mol Med.
- 2014 Apr;46(4):e90.
- doi: 10.1038/emm.2014.1
Syntenin is a PDZ domain-containing adaptor protein that has been recently shown to regulate migration and invasion in several tumors. Small cell lung cancer (SCLC) is notorious for its invasiveness... -
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- The Effect of the Genistein on the Proliferation of HT1080 and Expression of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA
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Kang JH, Myoung H, Kim MJ
- KMID: 2328354
- J Korean Assoc Oral Maxillofac Surg.
- 2001 Aug;27(4):314-320.
Matrix metalloproteinases have long been viewed as ideal candidates for proteinases that enables tumor cells to permeated basement membrane defenses and invade surrounding tissue. There is growing evidence that the... -
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- The Role of PKCzeta on MT1-MMP Expression with Shear Stress and Cyclic Strain in Microvascular Endothelial Cells
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Yun SS, Kim JI, Moon IS
- KMID: 2096845
- J Korean Soc Vasc Surg.
- 2007 Nov;23(2):120-127.
PURPOSE: hear stress (SS) and cyclic strain (CS) influence the expression of membrane type 1-matrix metalloproteinase (MT1-MMP) in microvascular endothelial cells (MVECs). It is known that changes in the level... -
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- Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in Human Abdominal Aortic Aneurysms
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Jung IM, Chung JK, Min SK, Seo JW, Park JH, Ha J, Kim SJ
- KMID: 2145117
- J Korean Surg Soc.
- 2004 Sep;67(3):214-230.
PURPOSE: Among the theories in the pathogenesis of abdominal aortic aneurysms, matrix metalloproteinase (MMP)- induced excessive degradation of extracellular matrix protein has been widely recognized. Normally, MMPs keep a balance... -
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- MT1-MMP and Egr-1 Expressions Induced by Different Strengths of Shear Stress in Endothelial Cell
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Yun SS, Jeon SY, Park JK, Lee S, Choi SH, Koh YB
- KMID: 1941115
- J Korean Soc Vasc Surg.
- 2003 May;19(1):5-12.
PURPOSE: Membrane type-1-matrix metalloproteinase (MT1-MMP) plays a key role in endothelial cell (EC) migration, matrix remodeling, and angiogenesis. Previous studies demonstrated that a cyclic strain (CS) increases MT1-MMP expression by... -
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- The Expression of MT1-MMP and E-cadherin mRNA in Invasive Cervical Cancer
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Moon HS, Choi EA, Chung HW, Kim SC
- KMID: 2244942
- Korean J Gynecol Oncol Colposc.
- 2002 Jun;13(2):106-115.
OBJECTIVES: There are adhesion molecules, angiogenetic factors, and proteolytic enzymes such as E-cadherin and MT1-MMP, which are involved in carcinogenesis, cancer invasion and metastasis. The aim of this study was... -
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- The Effects of Recombinant Synucleins and Insulin-like Growth Factor 1 on Cancer Cell Migration
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Shin W, Kim J
- KMID: 1717684
- J Bacteriol Virol.
- 2012 Jun;42(2):133-151.
- doi: 10.4167/jbv.2012.42.2.133
The synuclein family consists of three distinct genes, alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha-synuclein and beta-synuclein are predominately expressed in brain and especially alpha-synuclein is related with Parkinson's disease, Alzheimer's... -
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- Stromelysin-1 and Membrane type-MMP-1 Expressions in Human Chronic Periodontitis with Type 2 Diabetes Mellitus
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Ryu SH, Park JW, Suh JY, Lee JM
- KMID: 1999595
- J Korean Acad Periodontol.
- 2008 Dec;38(4):629-638.
- doi: 10.5051/jkape.2008.38.4.629
PURPOSE: The purposes of this study were to compare and quantify the expression of Stromelysin-1 and MT-MMP-1 in the gingival tissues of patients with type 2 diabetes mellitus(DM) and healthy... -
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