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Macrolides

Choung JT

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Anti-Inflammatory Effect and Its Clinical Significance of Macrolides

Chung EH

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Proper use of new macrolides in pediatrics

Yun BY

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Successful Treatment of Eosinophilic Gastroenteritis with Clarithromycin

Ohe M, Hashino S

  • KMID: 2432938
  • Korean J Intern Med.
  • 2012 Dec;27(4):451-454.
Eosinophilic gastroenteritis (EGE) is an uncommon disease characterized by eosinophilic infiltration of the gastrointestinal tract, which is usually associated with abdominal pain, diarrhea, ascites, and peripheral eosinophilia. Steroids remain the...
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Effects of Erythromycin and New Macrolides on the Serum Theophylline Level and Clearance

Lee HB, Lee YC, Rhee YK

BACKGROUND: Up to 90% of a theophylline dose is biotransformed, by interaction with one or more the variants of the cytochrome P-450 drug metabolism system. Macrolides affect the elimination of...
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Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia

Oh JH, Oh DJ, Koo SM, Kim YK, Kim KU, Kim HJ, Kim DW, Uh ST

Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used...
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Erythromycin Inhibits Interleukin-6 and Interleukin-8 Expression and Promotes Apoptosis of Activated Human Neutrophils in Vitro

Baik AR, Lee J

  • KMID: 1512891
  • Korean J Physiol Pharmacol.
  • 2007 Dec;11(6):259-262.
Diffuse panbronchiolitis (DPB) is a pulmonary disease characterized by chronic inflammation of the bronchioles and chronic infiltration of inflammatory cells in the lungs. Macrolides are effective therapeutic agents for chronic...
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Successful treatment with erythromycin for idiopathic thrombocytopenic purpura

Ohe M, Hashino S

Macrolides have both immunomodulatory and antibacterial effects. We report 3 cases of primary immune thrombocytopenia (ITP) patients who were successfully treated with macrolides, irrespective of Helicobacter pylori (H. pylori) infection...
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Diffuse panbronchiolitis in an adolescent female

Kim HY, Son SK, Park HJ

Diffuse panbronchiolitis (DPB) is a progressive inflammatory respiratory disease of unknown cause mainly occurring in East Asian people. Studies on causes of the disease point to a genetic predisposition unique...
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The Effect of Macrolide Therapy on Bronchopulmonary Dysplasia in Ureaplasma-Positive Very Low Birth Weight Infants

Kim S, Kim CY, Jung E, Kim H, Song WS, Lee BS, Kim EA, Kim KS

OBJECTIVE: Ureaplasma has been demonstrated the cause of short and long-term morbidities of preterm infants, especially such as bronchopulmonary dysplasia (BPD). This study aims to evaluate the influence of Ureaplasma...
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The Anti-tumor Effect of Macrolides on the Extracellular Matrix Invasion and Cell Adhesion in Human Non-small Cell Lung Cancer Cells

Han SJ, Yoo CG, Lee CT, Han SK, Shim YS, Kim YW

  • KMID: 2005749
  • J Lung Cancer.
  • 2004 Dec;3(2):113-121.
PURPOSE: We investigated the effect of macrolides on the extracellular matrix (ECM) invasion and expression of cell adhesion proteins in non-small cell lung cancer cells. MATERIALS AND METHODS: Three kinds...
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A case of anaphylaxis to erythromycin

Park JG, Seo EK, Cho YS, Jang JS, Joo HJ, Lee SH, Kim MK

  • KMID: 2259150
  • Korean J Med.
  • 2010 May;78(5):660-663.
Macrolides antibiotics synthesized by Streptomyces strains are prescribed widely and seldom produce hypersensitivity reactions, even when administered topically. Consequently, they are considered very safe drugs. We report the case of...
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Predictive value of C-reactive protein in response to macrolides in children with macrolide-resistant Mycoplasma pneumoniae pneumonia

Seo YH, Kim JS, Seo SC, Seo WH, Yoo Y, Song DJ, Choung JT

PURPOSE: The prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) has increased worldwide. The aim of this study was to estimate the proportion of MRMP in a tertiary hospital in Korea, and...
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Eribulin for Advanced Breast Cancer: A Drug Evaluation

Shablak A

  • KMID: 2374539
  • J Breast Cancer.
  • 2013 Mar;16(1):12-15.
Eribulin is a synthetic microtubule dynamics inhibitor that was developed from a marine natural product halichondrin B. It exhibited in vitro and in vivo activities against a wide number of...
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Emergence of macrolide resistance and clinical use of macrolide antimicrobials in children

Choi EH

Macrolide antimicrobial agents including erythromycin, roxithromycin, clarithromycin, and azithromycin are commonly used in the treatment of respiratory tract infections in children. Newer macrolides that have structural modifications of older drug...
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Epidemiology and Erythromycin Resistance of Streptococcus pyogenes in the Last 20 Years

Kim S

Serological methods for the epidemiological study of Streptococcus pyogenes, such as T-, or M-typing, were replaced by emm typing in the 2000s. The frequency of emm types may differ according...
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Mechanism of resistance acquisition and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

Yang HJ, Song DJ, Shim JY

Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children and adolescents. Outbreaks of MPP occur in 3- to 7-year cycles worldwide; recent epidemics...
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Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children

Yang HJ

Although Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, the emergence of macrolide-resistant MPP (MRMP) has made its treatment challenging. MRMP rapidly spread after the 2000s, especially in...
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Ureaplasma infections in pre-term infants: Recent information regarding the role of Ureaplasma species as neonatal pathogens

Sung TJ

Although numerous clinical observational studies have been conducted over a period of over 30 years, the clinical significance of Ureaplasma infection is still under debate. The Ureaplasma speices. is a...
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Roxithromycin Suppresses MUC5B/8 Mucin Genes and Mucin Production in Airway Epithelial Cells

Woo HJ, Min MK, Bae CH, Song SY, Kim YD

  • KMID: 2141201
  • Korean J Otorhinolaryngol-Head Neck Surg.
  • 2008 Jul;51(7):617-622.
BACKGROUND AND OBJECTIVES: Macrolide antibiotics are known to inhibit mucus hypersecretion in patients with chronic airway diseases, but its action mechanism is unclear. Several reports demonstrated that macrolides significantly inhibited...
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