- IL-1beta Induces Lysozyme Overexpression through a Mechanism Involving ERK/p38 Mitogen Activated Protein Kinase Activation in Human Airway Epithelial Cells
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Kim YS, Yang WS, Moon UY, Lee JG, Yoon JH
- KMID: 2297667
- J Rhinol.
- 2007 Nov;14(2):100-105.
BACKGROUND AND OBJECTIVES: Lysozyme, a major serous component of airway epithelial secretions, plays an important role in airway defense. However, little is understood about the regulation of its expression and... -
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- Involvement of MAP Kinases in Apoptosis of Macrophage Treated with Trichomonas vaginalis
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Ryang YS, Chang JH, Park JY
- KMID: 721432
- Yonsei Med J.
- 2004 Aug;45(4):751-754.
- doi: 10.3349/ymj.2004.45.4.751
A primitive protozoan parasite Trichomonas vaginalis selectively activates the signal transduction pathways in macrophages (RAW264.7). This study evaluated the correlation of these signaling pathways and T. vaginalis-induced cell apoptosis. In... -
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- Effect of Cholesterol Depletion on Interleukin-8 Production in Human Respiratory Epithelial Cells
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Kim MJ, Hong JY, Lee KE, Kim KW, Sohn MH, Kim KE
- KMID: 2260285
- Allergy Asthma Immunol Res.
- 2013 Nov;5(6):402-408.
- doi: 10.4168/aair.2013.5.6.402
PURPOSE: The lipid entities of cell membranes are components of the immune system and important mediators of inflammation. Despite increasing interest in the function of epithelial cells in inflammation, the... -
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- Signaling Pathway of the Bacterial Lipopolysaccharide-induced Generation of Nitric Oxide in Rat Primary Astorcytes
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Kwang S, Park RK, Lee SY, Park MC
- KMID: 2340348
- J Korean Neuropsychiatr Assoc.
- 1999 Jul;38(4):881-893.
OBJECTIVES: Nitric oxide(NO)plays an important role in pathophysiology of stroke and various neurodegenerative diseases. This study is designed to elucidate the mechanisms by which signaling pathway of LPS-stimulated NO... -
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- Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways
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Joo HJ, Jeong KH, Kim JE, Kang H
- KMID: 2395183
- Ann Dermatol.
- 2017 Dec;29(6):747-754.
- doi: 10.5021/ad.2017.29.6.747
BACKGROUND: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth. OBJECTIVE: The aim of this study was to investigate the effect of different... -
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- Toll-like receptor signal transduction
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Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S
- KMID: 756065
- Exp Mol Med.
- 2007 Aug;39(4):421-438.
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous pathogens. Activation of TLRs is a first line of defense of the immune system, leading to the activation... -
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- Dexamethasone-induced differentiation of pancreatic AR42J cell involves p21(waf1/cip1)and MAP kinase pathway
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Eum WS, Li MZ, Sin GS, Choi SY, Park JB, Lee JY, Kwon HY
- KMID: 1093610
- Exp Mol Med.
- 2003 Oct;35(5):379-384.
Dexamethasone converts pluripotent pancreatic AR42J cells into exocrine cells expressing digestive enzymes. In order to address molecular mechanism of this differentiation, we have investigated the role of mitogen-activated protein (MAP)... -
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- Role of fibroblasts in organotypic cultures of immortalized human oral keratinocytes
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Cheong JK, Yoon KH, Kim EC
- KMID: 2190271
- J Korean Assoc Oral Maxillofac Surg.
- 2007 Jun;33(3):211-220.
OBJECTIVE: In organotypic culture of immortalized human oral keratinocytes (IHOK), the change of the growth and differentiation was investigated according to the fibroblast type and the involvement of mitogen-activated protein... -
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- Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy
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Yoon YW, Kang TS, Lee BK, Chang W, Hwang KC, Rhee JH, Min PK, Hong BK, Rim SJ, Kwon HM
- KMID: 1094119
- Exp Mol Med.
- 2008 Aug;40(4):398-406.
- doi: 10.3858/emm.2008.40.4.398
Advanced glycation endproducts (AGEs) have been reported to play a role in neointimal formation and increase the rate of in-stent restenosis (ISR) in the diabetic coronary artery disease patients treated... -
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- Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4
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Lee KH, Choi EY, Hyun MS, Kim JR
- KMID: 755666
- Exp Mol Med.
- 2004 Feb;36(1):57-64.
Clinical studies have shown that tumor hypoxia is associated with invasive growth and metastasis and may be an important prognostic factor adversely influencing survival in patients with tumors. To investigate... -
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- p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Regulate Nitric Oxide Production and Inflammatory Cytokine Expression in Raw Cells
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Choi CH, Kim SH
- KMID: 2150587
- Immune Netw.
- 2005 Mar;5(1):30-35.
- doi: 10.4110/in.2005.5.1.30
BACKGROUND: p38 and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) signaling are thought to have critical role in lipopolysaccharide (LPS)-induced immune response but the molecular mechanism underlying the induction... -
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- Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells through the Activation of the MAPK/ERK Pathway
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Berardi DE, Raffo D, Todaro LB, Simian M
- KMID: 2394806
- Cancer Res Treat.
- 2017 Oct;49(4):869-879.
- doi: 10.4143/crt.2016.378
PURPOSE: We investigated the effects of laminin on the fraction of cells with self-renewing capacity in the estrogen-dependent, tamoxifen-sensitive LM05-E breast cancer cell line. We also determined whether laminin affected... -
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- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- Influence of the Angiotensin II AT1 Receptor Antagonist on Reperfusion Injury in Rat Myocardial Ischemia Model
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Nam JH, Lee JE, Kim EJ, Park SJ, Jin BC, Park TJ, Choi JY, Choi DJ, Seo BG
- KMID: 1938934
- Korean Circ J.
- 2001 Nov;31(11):1150-1158.
- doi: 10.4070/kcj.2001.31.11.1150
BACKGROUND AND OBJECTIVES: The protective effect of angiotensin converting enzyme (ACE) inhibitor against ischemia/reperfusion injury has been demonstrated in animal models, however the effect of AT1 receptor antagonist is contradictory.... -
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- Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells
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Nakamura M, Ozaki T, Ishii A, Konishi M, Tsubota Y, Furui T, Tsuda H, Mori I, Ota K, Kakudo K
- KMID: 1123804
- Exp Mol Med.
- 2009 May;41(5):307-314.
- doi: 10.3858/emm.2009.41.5.034
Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to... -
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- Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
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Oh SY, Park KS, Kim AJ, Choi KY
- KMID: 1093594
- Exp Mol Med.
- 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,... -
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- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
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Kim EC, Kim SH, Piao SJ, Kim TJ, Bae K, Kim HS, Hong SS, Lee BI, Nam M
- KMID: 2164486
- J Korean Med Sci.
- 2015 Jul;30(7):979-987.
- doi: 10.3346/jkms.2015.30.7.979
Angiogenesis, the formation of new blood vessels, is critical for tumor growth and metastasis. Notably, tumors themselves can lead to angiogenesis by inducing vascular endothelial growth factor (VEGF), which is... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Protein kinase C micron plays an essential role in hypertonicity-induced heat shock protein 70 expression
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Lim YS, Lee JS, Huang TQ, Seo JS
- KMID: 1072940
- Exp Mol Med.
- 2008 Dec;40(6):596-606.
- doi: 10.3858/emm.2008.40.6.596
Heat shock protein 70 (HSP70), which evidences important functions as a molecular chaperone and anti-apoptotic molecule, is substantially induced in cells exposed to a variety of stresses, including hypertonic stress,... -
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- Expression and Regulation of Endothelial Nitric Oxide Synthase by Vascular Endothelial Growth Factor in ECV 304 Cells
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Park JS, Hong GR, Baek SW, Shin DG, Kim YJ, Shim BS
- KMID: 648670
- J Korean Med Sci.
- 2002 Apr;17(2):161-167.
- doi: 10.3346/jkms.2002.17.2.161
Nitric oxide (NO) seems to play a pivotal role in the vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. This study was designed to investigate the role and intracellular signal... -
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