- Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration
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Ban YH, Ha SJ
- KMID: 2400636
- Immune Netw.
- 2017 Oct;17(5):307-316.
- doi: 10.4110/in.2017.17.5.307
Quantitative PCR and plaque assay are powerful virological techniques used to measure the load of defective or infectious virus in mouse and human. However, these methods display limitations such as... -
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- Extrinsic Acquisition of CD80 by Antigen-Specific CD8⺠T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
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Son J, Ha SJ
- KMID: 2455935
- Immune Netw.
- 2019 Aug;19(4):e25.
- doi: 10.4110/in.2019.19.e25
CD80 is mainly expressed on Ag-presenting cells (APCs) as a costimulatory molecule but is also detected on T cells. However, the origin and physiological role of CD80 on CD8⺠T... -
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- Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8⺠T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection
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Son J, Cho YW, Woo YJ, Baek YA, Kim EJ, Cho Y, Kim JY, Kim BS, Song JJ, Ha SJ
- KMID: 2444159
- Immune Netw.
- 2019 Apr;19(2):e11.
- doi: 10.4110/in.2019.19.e11
During virus infection, T cells must be adapted to activation and lineage differentiation states via metabolic reprogramming. Whereas effector CD8⺠T cells preferentially use glycolysis for their rapid proliferation, memory... -
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- Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
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Im SJ, Ha SJ
- KMID: 2471042
- Immune Netw.
- 2020 Feb;20(1):e2.
- doi: 10.4110/in.2020.20.e2
Acute viral infection or vaccination generates highly functional memory CD8 T cells following the Ag resolution. In contrast, persistent antigenic stimulation in chronic viral infection and cancer leads to a... -
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- Enhancing T Cell Immune Responses by B Cell-based Therapeutic Vaccine Against Chronic Virus Infection
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Kim MK, Lee A, Hwang YK, Kang CY, Ha SJ
- KMID: 2150809
- Immune Netw.
- 2014 Aug;14(4):207-218.
- doi: 10.4110/in.2014.14.4.207
Chronic virus infection leads to the functional impairment of dendritic cells (DCs) as well as T cells, limiting the clinical usefulness of DC-based therapeutic vaccine against chronic virus infection. Meanwhile,... -
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- Detection of Foreign Antigen-specific CD4+Foxp3+ Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining
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Choi JY, Eo SK
- KMID: 2150787
- Immune Netw.
- 2013 Dec;13(6):264-274.
- doi: 10.4110/in.2013.13.6.264
The unrestricted population of CD4+Foxp3+ regulatory T (Treg) cells, which have been known to control the expression of autoimmune diseases and protective immunity to inflammatory reactions, has led to greater... -
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