- A case report of primary T-cell lymphoma of the liver
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Kim HS, Ko YH, Ree HJ
- KMID: 648131
- J Korean Med Sci.
- 2000 Apr;15(2):240-242.
- doi: 10.3346/jkms.2000.15.2.240
The patient was a 50-year-old woman who presented intermittent mild fever with elevated liver enzymes for 12 years. The liver biopsy showed diffuse portal and sinusoidal involvement of lymphoid cells... -
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- Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
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Kim JR, Kim SY, Kim MJ, Kim JH
- KMID: 754996
- Exp Mol Med.
- 1998 Jun;30(2):109-114.
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers.... -
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- Knockdown of 14-3-3zeta enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells
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Lee YK, Hur W, Lee SW, Hong SW, Kim SW, Choi JE, Yoon SK
- KMID: 2155342
- Exp Mol Med.
- 2014 Feb;46(2):e77.
- doi: 10.1038/emm.2013.151
14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study,... -
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- Viral loads and E2/NS1 region sequences of hepatitis C virus in hepatocellular carcinoma and surrounding liver
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Park CK, Park TR, Kim YB, Kim HY, Yoo JY, Kim CH, Choo SH, Cho JM
- KMID: 1038874
- Korean J Intern Med.
- 1997 Jan;12(1):28-33.
OBJECTIVES: Numerous epidemiologic data have documented that chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). But the molecular mechanism... -
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- Analysis of the precore and core promoter DNA sequence in liver tissues from tients with hepatocellular carcinoma
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Cho SW, Shin YJ, Hahm KB, Jin JH, Kim YS, Kim JH, Kim HJ
- KMID: 1731317
- J Korean Med Sci.
- 1999 Aug;14(4):424-430.
- doi: 10.3346/jkms.1999.14.4.424
To investigate the role of mutant hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC), 20 patients with HCC were studied for precore and core promoter mutations in... -
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- Role of Long Non-coding Ribonucleic Acid in Gastrointestinal Cancer
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Park CH, Lee SK
- KMID: 1711287
- Korean J Gastroenterol.
- 2013 Dec;62(6):317-326.
- doi: 10.4166/kjg.2013.62.6.317
With the improvement of high-throughput genomic technology such as microarray and next-generation sequencing over the last ten to twenty year, we have come to know that the portion of the... -
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- Ectopic Over-expression of Oncogene Pim-2 Induce Malignant Transformation of Nontumorous Human Liver Cell Line L02
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Ren K, Duan W, Shi Y, Li B, Liu Z, Gong J
- KMID: 1792950
- J Korean Med Sci.
- 2010 Jul;25(7):1017-1023.
- doi: 10.3346/jkms.2010.25.7.1017
In order to prove that ectopic over-expression of Pim-2 could induce malignant transformation of human liver cell line L02, three groups of cells were set up including human liver cell... -
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- Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas in Korea
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Lee HS, Kim ST, Kim CY
- KMID: 1421492
- J Korean Med Sci.
- 1990 Sep;5(3):145-148.
- doi: 10.3346/jkms.1990.5.3.145
The rate of HBV DNA integration into the genome of hepatocellular carcinoma (HCC) cells varies greatly among HCC tissues from different geographical districts. Because of the potential etiological significance of... -
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- Triton X-100 induces apoptosis in human hepatoma cell lines
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Ahn JM, Kim SJ, Kim H, Park C, Kim WH, Park JH
- KMID: 699929
- Yonsei Med J.
- 1997 Feb;38(1):52-59.
- doi: 10.3349/ymj.1997.38.1.52
The detergent Triton X-100 was used to establish a model for apoptosis in hepatoma cell lines. The electrophoresis of DNA extracted from 0.01% Triton X-100 treated hepatoma cell... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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- Mutation analysis of p31(comet) gene, a negative regulator of Mad2, in human hepatocellular carcinoma
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Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH
- KMID: 756074
- Exp Mol Med.
- 2007 Aug;39(4):508-513.
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment... -
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- IL28B Is Associated with Outcomes of Chronic HBV Infection
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Shi X, Chi X, Pan Y, Gao Y, Li W, Yang C, Zhong J, Xu D, Zhang M, Minuk G, Jiang J, Niu J
- KMID: 2450334
- Yonsei Med J.
- 2015 May;56(3):625-633.
- doi: 10.3349/ymj.2015.56.3.625
PURPOSE: The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are... -
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- Hepatitis C virus and hepatocarcinogenesis
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Jeong SW, Jang JY, Chung RT
- KMID: 1410890
- Clin Mol Hepatol.
- 2012 Dec;18(4):347-356.
- doi: 10.3350/cmh.2012.18.4.347
Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The... -
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- Cyclosporin A Inhibits Albumin Synthesis in Huh7 Cells
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Jeon YJ, Kim YS
- KMID: 1022171
- Korean J Intern Med.
- 2011 Sep;26(3):314-319.
- doi: 10.3904/kjim.2011.26.3.314
BACKGROUND/AIMS: Hypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. METHODS: Huh7 cells were... -
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- Adaptive response to ionizing radiation induced by low dose of gamma ray in human hepatoma cell lines
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Seong J, Kim GE
- KMID: 1381220
- Yonsei Med J.
- 1994 Mar;35(1):77-83.
- doi: 10.3349/ymj.1994.35.1.77
When cells are exposed to a low dose of a mutagenic or clastogenic agent, they often become less sensitive to the effects of a higher dose administered subsequently. Such adaptive... -
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