- Leukotrienes and Allergic Inflammation
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- KMID: 1969527
- Korean J Asthma Allergy Clin Immunol.
- 2012 Jun;32(2):67-72.
Leukotrienes (LTs) are important lipid mediators involved in allergic inflammation. The LT pathway is relatively steroid-resistant, which suggests the possibility that its blockade by alternative means may facilitate asthma management.... -
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- Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
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Kanaoka Y, Boyce JA
- KMID: 2260208
- Allergy Asthma Immunol Res.
- 2014 Jul;6(4):288-295.
- doi: 10.4168/aair.2014.6.4.288
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties... -
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- Inhibitory Effect of Rebamipide on Helicobacter pylori Induced Release of Leukotriene D4
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Lee JJ, Han BG, Kim MN, Chung MH
- KMID: 1943438
- J Korean Soc Microbiol.
- 1997 Dec;32(6):653-658.
It has been implicated that leukotrienes play roles in the pathogenesis of gastritis and gastric ulceration associated with Helicobacter pylori (H. pylori). Rebamipide is being used as an antiulcer drug... -
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- Effects of Eupatilin on the Release of Leukotriene B4 , by Helicobacter pylori - stimulated Neutrophils and Gastric Mucosal Cells
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Lee JJ, Han BG, Kim MN, Chung MH
- KMID: 1943439
- J Korean Soc Microbiol.
- 1997 Dec;32(6):659-666.
Leukotrienes (LTs) are known to act as a mediator provoking tissue response in inflammation. LTs, particularly type B4 (LTB4) as chemotactic factor of neutrophil are released from neutrophils and gastric... -
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- Emerging Therapies in Chronic Spontaneous Urticaria
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Min TK, Saini SS
- KMID: 2448750
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):470-481.
- doi: 10.4168/aair.2019.11.4.470
Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to... -
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- Mast Cells and Allergic Rhinitis
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Cho JS
- KMID: 2297727
- J Rhinol.
- 1998 Nov;5(2):85-91.
That mast cells play a role in acute allergic inflammation by releasing various inflammatory mediators, including histamine, leukotrienes (LT), such as LTC4 and LTD4, and prostaglandins (PG), such as PGD2,... -
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- Effects of ginsenosides on the mechanism of histamine release in the guinea pig lung mast cells activated by specific antigen-antibody reactions
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Ro JY, Ahn YS, Kim KH
- KMID: 2071516
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):445-456.
We previously reported that some components of ginsenosides decreased mediator releases evoked by the activation of mast cells with specific antigen-antibody reactions. This study aimed to assess the effects of ginsenosides (Rb2, Re)... -
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- Treatment of Allergic Rhinitis
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Hur GY
- KMID: 2267767
- Korean J Med.
- 2013 Nov;85(5):463-468.
Allergic rhinitis (AR) is defined as chronic inflammatory reactions to common allergens in the nasal mucosa with at least two AR symptoms including rhinorrhea, nasal congestion, sneezing, nasal/ocular pruritus, and... -
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- Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma
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Shin KS, Kim YW
- KMID: 1855968
- Korean J Pediatr.
- 2005 Jul;48(7):766-771.
PURPOSE: Cysteinyl leukotrienes are important inflammatory mediators in the pathogenesis of asthma; therefore interruption of cysteinyl leukotrienes by leukotriene receptor antagonists improves clinical symptoms in the management of patients with... -
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- Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?
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Sanak M
- KMID: 2349987
- Allergy Asthma Immunol Res.
- 2016 Nov;8(6):481-490.
- doi: 10.4168/aair.2016.8.6.481
Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages. Among the most significant biologically lipid mediators, these are produced by free-radical... -
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- Complementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory Disease
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Lee JU, Park JS, Chang HS, Park CS
- KMID: 2459183
- Allergy Asthma Immunol Res.
- 2019 Nov;11(6):779-794.
- doi: 10.4168/aair.2019.11.6.779
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) has attracted a great deal of attention because of its association with severe asthma. However, it remains widely underdiagnosed in asthmatics as well... -
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- 5-Lipoxygenase Promotor Polymorphism in Nasal Polyp Patients
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Park SK, Choi JB, Jung H, Yea SS
- KMID: 2276733
- Korean J Otolaryngol-Head Neck Surg.
- 2007 Apr;50(4):310-313.
BACKGROUND AND OBJECTIVES: Nasal polyps are the most common mass lesions in the nasal cavity and occur on both infectious and noninfectious basis, and genetic etiology is suspected in the... -
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- Clinical application of urinary leukotriene E4 in bronchial asthma
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Yoon HK, Shin Y, Lee SH, Lee SY, Kim SC, Kim KH, Moon HS, Song JS, Park SH
- KMID: 2285928
- J Asthma Allergy Clin Immunol.
- 2001 Aug;21(4):600-609.
BACKGROUND: Cysteinyl leukotrienes are important inflammatory mediators in bronchial asthma because they enhance microvascular permeability, increase nonspecific bronchial hyperresponsiveness, and are potent bronchoconstrictor agents. Leukotriene E4 is a major metabolite... -
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- The Effect of Montelukast in the Treatment of Atopic Dermatitis through the SCORAD Index
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Lee YK, Kim YH, Kim KH, Lee CW
- KMID: 2087907
- Korean J Dermatol.
- 2008 Jan;46(1):34-39.
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease, with genetic and environmental background. The pathogenesis is complex, and although the dermatitis fades during childhood in most cases,... -
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- Correlation between the Level of Urinary Leukotriene E4 and Seurm Eosinophil Cationic Protein and Clinical Severity of Atopic Dermatitis in Children
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- KMID: 2234226
- Korean J Asthma Allergy Clin Immunol.
- 2004 Dec;24(4):409-414.
BACKGROUND: Atopic dermatitis is a chronic inflammatory relapsing skin disorder. It has been shown that urinary LTE4 and serum ECP level are elevated and correlated with disease activity. OBJECTIVE: We... -
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- Effects of ATP and LTC4 on hypoxic pulmonary vasoconstriction in isolated rat lungs
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Rho JY, Shin HY, Kim HC, Lee JW, Kim SD
- KMID: 1765452
- Korean J Anesthesiol.
- 2009 Oct;57(4):472-482.
- doi: 10.4097/kjae.2009.57.4.472
BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as... -
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- Cromakalim blocks membrane phosphoinositide activated signals in the guinea pig lung mast cells stimulated with antigen-antibody reactions
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Ro JY, Kim JY, Kim KH
- KMID: 1562328
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):251-260.
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by... -
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- The effects of cromakalim on the mediator releases from guinea pig lung mast cell activated by specific antigen-antibody reactions
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Ro JY, Yim YN, Kim KH
- KMID: 699910
- Yonsei Med J.
- 1996 Oct;37(5):325-338.
- doi: 10.3349/ymj.1996.37.5.325
The inhibitory effect of cromakalim on the mediator release from mast cells caused by antigenantibody reactions was in controversy with the specific antigen used. However, it has recently been observed... -
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- Arachidonic Acid Metabolites in Antrochoanal Polyp and the Nasal Polyp Associated with Chronic Paranasal Sinusitis
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Rhee CK, Jang YJ
- KMID: 2074329
- Korean J Otolaryngol-Head Neck Surg.
- 1999 Jan;42(1):54-57.
BACKGROUND AND OBJECTIVES: It is known that various inflammatory mediators released from the eosinophils and mast cells play important roles in the pathogenesis of nasal polyp. Among those mediators, the... -
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- MUC2/5AC Expression and Mucin Secretion through Leukotriene Receptor in Human Airway Epithelial Cells
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Kim YD, Lee JE, Bai CH, Seo YJ, Ye SB, Song SY
- KMID: 2276273
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Nov;47(11):1115-1119.
BACKGROUND AND OBJECTIVES: Mucin gene expression and mucin production are highly increased during inflammatory airway disorders such as, asthma, chronic bronchitis and sinusitis. Cytokines, lipopolysaccharides and other inflammatory mediators are... -
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