J Korean Soc Microbiol.  1997 Dec;32(6):659-666.

Effects of Eupatilin on the Release of Leukotriene B4 , by Helicobacter pylori - stimulated Neutrophils and Gastric Mucosal Cells

• Lee JJ
• Han BG
• Kim MN
• Chung MH

Abstract

Leukotrienes (LTs) are known to act as a mediator provoking tissue response in inflammation. LTs, particularly type B4 (LTB4) as chemotactic factor of neutrophil are released from neutrophils and gastric mucosal cells when these cells are stimulated by Helicobacter pylori. The present study was performed to test a possibility that eupatilin may prevent the H. pylori-induced gastric cell damage by observing whether this chemical inhibit the release of LTB4 from H. pylori-stimulated gastric cells (Kato III) and neutrophils. As observed in the previous study, H. pylori induced the release of LTB4 from these cells and at the same influx of Ca2+ into the cells. In the presence of eupatilin, the release of LTB4 was inhibited whereas Ca2+ influx was not affected. Probably eupatilin may inhibit the release of LTB4 by preventing the synthesis of LTs. These results suggest that eupatilin can has a therapeutic effect on H. pylori-induced gasric cell damage.

MeSH Terms

Helicobacter pylori*
Helicobacter*
Inflammation
Leukotriene B4*
Leukotrienes
Neutrophils*
Leukotriene B4
Leukotrienes