- Gene Therapy in Rats with a Lentiviral Vector Containing the Human Coagulation Factor IX Gene
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Kim ST, Oh T, Jeon HJ, Kim OH, Lee SM
- KMID: 1477826
- Korean J Blood Transfus.
- 2008 Apr;19(1):1-8.
BACKGROUND: Hemophilia B is an inheritable X-linked bleeding disorder that occurs as a consequence of genetic alterations within the factor IX (IX) gene. In the present study, pseudotyped HIV-I-derived lentiviral... -
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- Differential Cellular Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus Monkey
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An H, Cho DW, Lee SE, Yang YS, Han SC, Lee CJ
- KMID: 2165578
- Exp Neurobiol.
- 2016 Feb;25(1):48-54.
- doi: 10.5607/en.2016.25.1.48
Many researchers are using viruses to deliver genes of interest into the brains of laboratory animals. However, certain target brain cells are not easily infected by viruses. Moreover, the differential... -
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- Transduction of eGFP Gene to Human Embryonic Stem Cells and Their Characterization
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Kim YY, Ku SY, Park YB, Oh SK, Moon SY, Choi YM
- KMID: 2288259
- Korean J Reprod Med.
- 2009 Dec;36(4):283-292.
OBJECTIVE: Human embryonic stem cells (hESCs) can proliferate indefinitely and differentiate into all kinds of cell types in vitro. Therefore, hESCs can be used as a cell source for cell-based... -
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- Inhibition of in vitro hepatitis B virus replication by lentivirus-mediated short-hairpin RNA against HBx
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Kim JW, Lee SH, Park YS, Jeong SH, Kim N, Lee DH
- KMID: 1776811
- Korean J Hepatol.
- 2009 Mar;15(1):15-24.
- doi: 10.3350/kjhep.2009.15.1.15
BACKGROUNDS/AIMS: Hepatitis B virus (HBV) replicates via RNA intermediates, which could serve as targets for RNA interference (RNAi). Vector-mediated short-hairpin RNA (shRNA) can induce sustained RNAi in comparison to small... -
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- Comparison of Human Sodium/Iodide Symporter (hNIS) Gene Expressions between Lentiviral and Adenoviral Vectors in Rat Mesenchymal Stem Cells
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Park SY, Kim SJ, Lee WW, Lee H, Kim HJ, Chung JK, Kim SE
- KMID: 2051952
- Nucl Med Mol Imaging.
- 2008 Oct;42(5):394-400.
PURPOSE: Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirus-mediated delivery systems has not been reported. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression... -
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- Application of Induced Pluripotent Stem Cells in Rheumatology
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Jung SM, Ju JH
- KMID: 2223004
- J Rheum Dis.
- 2013 Oct;20(5):286-296.
- doi: 10.4078/jrd.2013.20.5.286
Since induced pluripotent stem cell (iPSC) was first introduced by Yamanaka in 2006, it took only six years to win a Nobel Prize for his pioneering work. It is unusual... -
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- Spectrin Cleavage Induced by LLP-1 Lentivirus Lytic Peptide Domain in the Intracytoplasmic Tail of Human Immunodeficiency Virus Type 1 GP41 in Rat Organotypic Hippocampal Slice Cultures
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Lee JH, Lee EO, Chong YH
- KMID: 2055033
- J Bacteriol Virol.
- 2006 Dec;36(4):247-254.
- doi: 10.4167/jbv.2006.36.4.247
We previously demonstrated that the lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induced cell death in human neuronal cells. Present study was conducted to... -
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- The Validation of RT-PCR Assay for Detection of Replication-competent Lentivirus (RCL) in Vector Preparations Using HIV Vector Based Gene Delivery System
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Yoo ES
- KMID: 2140620
- Korean J Pediatr Hematol Oncol.
- 2002 Apr;9(1):108-116.
PURPOSE: Unlike murine oncoretroviruses which can infect only dividing cells, lentiviral vector based on HIV have been shown to efficiently transfer genetic materials into a various cells which makes... -
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- Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo
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Wang XT, Xie YB, Xiao Q
- KMID: 1025167
- Exp Mol Med.
- 2011 Nov;43(11):638-645.
- doi: 10.3858/emm.2011.43.11.072
The E2F-1 transcription factor is post-translationally modified and stabilized in response to various forms of DNA damage to regulate the expression of cell-cycle and pro-apoptotic genes. The sustained overexpression of... -
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- Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis
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Wang Y, Lin L, Zheng C
- KMID: 1245261
- Exp Mol Med.
- 2012 Mar;44(3):177-190.
- doi: 10.3858/emm.2012.44.3.013
Orai1 is the key subunit of the Ca2+-release-activated Ca2+ channel. Our previous report has demonstrated that Orai1 expression in the airway was upregulated in the ovalbumin (OVA)-induced allergic rhinitis (AR)... -
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- Enforced Expression of BMI-1 in Postnatal Human CD34+ Cells Promotes Erythroid Differentiation
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Lee G, Kim BS, Shieh JH, Moore MA
- KMID: 2305199
- Korean J Hematol.
- 2007 Sep;42(3):241-249.
- doi: 10.5045/kjh.2007.42.3.241
BACKGROUND: The Polycomb-group gene Bmi-1 is known to be a molecular regulator of self-renewal of normal and leukemic stem cells and be involved in various aspects of cellular proliferation, differentiation,... -
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- Inhibition of hepatitis B virus replication by RNA interference
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Park YG
- KMID: 1776809
- Korean J Hepatol.
- 2009 Mar;15(1):1-6.
- doi: 10.3350/kjhep.2009.15.1.1
No abstract available. -
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- microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression
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Lee H, Kim C, Kang H, Tak H, Ahn S, Yoon SK, Kuh HJ, Kim W, Lee EK
- KMID: 2382689
- Exp Mol Med.
- 2017 May;49(5):e327.
- doi: 10.1038/emm.2017.33
Acquisition of resistance to anti-cancer drugs is a significant obstacle to effective cancer treatment. Although several efforts have been made to overcome drug resistance in cancer cells, the detailed mechanisms... -
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- Tracking the Fate of Muscle-derived Stem Cells: an Insight into the Distribution and Mode of Action
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Park HS, Choi GH, Hahn S, Yoo YS, Jung IM, Lee T
- KMID: 2319514
- Vasc Spec Int.
- 2014 Mar;30(1):11-18.
PURPOSE: To examine the fate of muscle-derived stem cells (MDSC) after injection into different host conditions and provide an insight for their mechanism of action. MATERIALS AND METHODS: MDSCs differentiated in... -
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- Effect of Small Hairpin RNA Molecules Targeting Angiotensin-converting Enzyme Gene in Spontaneously Hypertensive Rats
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Hong YM, Lee HR, Kim KC
- KMID: 2330959
- J Korean Soc Hypertens.
- 2012 Sep;18(3):105-116.
BACKGROUND: Interfering RNA (iRNA) represents a recent breakthrough in effective blocking of the target genes in mammalian cells. Angiotensin-converting enzyme (ACE) has been shown to play an important role in... -
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- Protection of Cardiomyocytes from Acute Ischemic Injury by Protein Kinase Cepsilon Expression
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Yoo JN, Lee SH, Jang SI, Kim SO, Lee KH, Park MA, Lim TH, Kwon JS, Cho MC, Kim YD
- KMID: 2227060
- Korean Circ J.
- 2007 Jul;37(7):327-333.
- doi: 10.4070/kcj.2007.37.7.327
BACKGROUND AND OBJECTIVES: Ischemic injury is the most common and important cause of myocardial damage. Over past decades, a number of studies have identified a protective mechanism known as ischemic... -
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- TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis
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Lian W, Liu X, Chen W
- KMID: 2460221
- Yonsei Med J.
- 2019 Nov;60(11):1045-1053.
- doi: 10.3349/ymj.2019.60.11.1045
PURPOSE: To explore the molecular mechanism of the upregulation of multidrug resistance-associated protein 4 (MRP4) in cholestasis. MATERIALS AND METHODS: The mRNA and protein levels of MRP4 in liver samples from... -
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- miR-34a Inhibitor May Effectively Protect against Sevoflurane-Induced Hippocampal Apoptosis through the Wnt/β-Catenin Pathway by Targeting Wnt1
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Zhao X, Sun Y, Ding Y, Zhang J, Li K
- KMID: 2426335
- Yonsei Med J.
- 2018 Dec;59(10):1205-1213.
- doi: 10.3349/ymj.2018.59.10.1205
PURPOSE: Research has shown that sevoflurane-induced toxicity causes neurodegeneration in the developing brain. miR-34a has been found to negatively regulate ketamine-induced hippocampal apoptosis and memory impairment. However, the role of... -
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- Effect of Small Hairpin RNA Targeting Endothelin-Converting Enzyme-1 in Monocrotaline-Induced Pulmonary Hypertensive Rats
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Son JS, Kim KC, Kim BK, Cho MS, Hong YM
- KMID: 2157974
- J Korean Med Sci.
- 2012 Dec;27(12):1507-1516.
- doi: 10.3346/jkms.2012.27.12.1507
The purpose of this study was to investigate the therapeutic effects of small hairpin RNA (shRNA) targeting endothelin-converting enzyme (ECE)-1 in monocrotaline (MCT)-induced pulmonary hypertensive rats. Ninty-four Sprague-Dawley rats were... -
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- Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1
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Kim SY, Ko YS, Park J, Choi Y, Park JW, Kim Y, Pyo JS, Yoo YB, Lee JS, Lee BL
- KMID: 2152293
- Cancer Res Treat.
- 2016 Jan;48(1):345-354.
- doi: 10.4143/crt.2014.247
PURPOSE: We previously reported that forkhead transcription factors of the O class 1 (FOXO1) expression in gastric cancer (GC) was associated with angiogenesis-related molecules. However, there is little experimental evidence... -
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