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Molecular Biological and Pathological Aspects of Intercostal Muscles and Intervertebral Discs in Adolescent Idiopathic Scoliosis in Korea

Kim HS, Kwon OR, Moon SH, Kim KH, Kim H, Kwon UH, Lee HM, Park JO, Shin DE, Ha JW, Shim CG

STUDY DESIGN: A molecular biological study of intercostal muscles and intervertebral disc cells of Korean scoliosis patients. OBJECTIVES: To study the pathological results of intercostal muscles and molecular biological activity of...
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Osteogenesis by Transfer of Bone Morphogenetic Protein-2 cDNA in Ligamentum Flavum Cells: Approach Toward Tissue Engineering

Moon SH, Kim H, Kwon UH, Won JH, Kim HS, Hahn SB, Lee HM

STUDY DESIGN: In-vitro experiment. OBJECTIVES: To determine the effect of bone morphogenetic protein-2 in the osteogenesis of human ligamentum flavum cells and test the feasibility of gene transfer to these cells. SUMMARY OF...
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Dual Roles of Ligamentum Flavum for Spinal Fusion: As an Osteoinductive Agent and Carrier for Ex-vivo Gene Transfer

Moon SH, Kim H, Kwon UH, Kim KH, Youn HK, Kim HS, Hahn SB, Lee HM

STUDY DESIGN: An in-vitro experiment using human ligamentum flavum (LF) and the adnovirus-BMP-2 construct, Ad/BMP-2. OBJECTIVES: To determine the dual roles of LF as an osteoinductive agent and carrier for ex-vivo...
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Animal Model and Gene Expression Analysis During the Accelerated Fracture Healing in Traumatic Brain Injury

Kim KH, Kim HS, Moon SH, Kim H, Kwon UH, Lee HM, Park HW, Hahn SB, Moon ES

  • KMID: 2104907
  • J Korean Orthop Res Soc.
  • 2003 Oct;6(2):177-185.
PURPOSE: This study was performed to create a traumatic brain injury (TBI) animal model of up-regulated bone formation, and to show the possibility of comprehensive analysis of early gene expression...
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The Effect of Pulsed Electromagnetic Field in Human Intervertebral Disc Cell

Kwon UH, Moon SH, Kim H, Lee KI, Jun JA, Kim HS, Lee HM

  • KMID: 2322896
  • J Korean Soc Spine Surg.
  • 2004 Dec;11(4):194-201.
STUDY DESIGN: An in vitro experiment. OBJECTIVES: To assess the effect of pulsed sinusoidal EMF on human intervertebral disc (IVD) cells. LITERATURE REVIEW SUMMARY: Electromagnetic field (EMF) is known to modify some...
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Mesenchymanl Stem Cell Based Intradiscal Gene Therapy: Therapeutic Implication in Degenerative Disc Disease

Kim H, Kwon UH, Lee KI, Song KH, Shin SY, Park SY, Park JO, Lee HM, Moon SH

STUDY DESIGN: In-vitro experiments using human mesenchymal stem cells (MSCs), intervertebral disc (IVD) cells and type 5 adenovirus/transforming growth factor-beta1 construct (Ad/TGF-beta1). OBJECTIVES: To determine the effect of MSC-based gene therapy...
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Tissue Engineering of the Intervertebral Disc with Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Gene Therapy

Kim HS, Lee KI, Kim H, Kwon UH, Nam MR, Jang JW, Cho IJ, Kim B, Lee HM, Moon SH

STUDY DESIGN: This is an in-vitro experiment using rabbit intervertebral disc (IVD) cells and growth factors. OBJECTIVES: We wanted to determine the effect of types I, and II atelocollagen and growth...
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Pulsed Electromagnetic Field Stimulates Cellular Proliferation in Human Intervertebral Disc Cells

Lee HM, Kwon UH, Kim H, Kim HJ, Kim B, Park JO, Moon ES, Moon SH

PURPOSE: The purpose of this study is to investigate the mechanism of cellular proliferation of electromagnetic field (EMF) on human intervertebral disc (IVD) cells. MATERIALS AND METHODS: Human IVD cells...
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Phenotypical Stability and Matrix Synthesis of Human Intervertebral Disc Cells in Response to Dexamethasone and Transforming Growth Factor-beta1

Pyo NS, Kwon UH, Moon SH, Kim H, Lee KI, Jun JA, Kim KT, Kim HS, Lee HM

STUDY DESIGN: An in vitro experiment. OBJECTIVES: To evaluate the mRNA expressions of matrix components, and analyze the cellular proliferation and proteoglycan synthesis of human intervertebral disc cells in response to...
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