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No Acceleration of Intervertebral Disc Degeneration after a Single Injection of Bupivacaine in Young Age Group with Follow-Up of 5 Years

Ohtori S, Inoue G, Orita S, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Nakamura J, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Takaso M, Toyone T, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Takahashi

STUDY DESIGN: Prospective study of changes in intervertebral disc degeneration after injection of bupivacaine. PURPOSE: To examine whether injection of bupivacaine into human intervertebral discs accelerates their degeneration. OVERVIEW OF LITERATURE: Bupivacaine...
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Transdermal Fentanyl for Chronic Low Back Pain

Ohtori S, Inoue G, Orita S, Eguchi Y, Ochiai N, Kishida S, Takaso M, Aoki Y, Kuniyoshi , Nakamura J, Ishikawa T, Arai G, Miyagi M, Kamoda H, Suzuki M, Toyone T, Takahashi

PURPOSE: Chronic low back pain is a common clinical problem. As medication, non-steroidal anti-inflammatory drugs are generally used; however, they are sometimes non-effective. Recently, opioids have been used for the...
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Injection of Bupivacaine into Disc Space to Detect Painful Nonunion after Anterior Lumbar Interbody Fusion (ALIF) Surgery in Patients with Discogenic Low Back Pain

Kimura S, Ohtori S, Orita S, Inoue G, Eguchi Y, Takaso M, Ochiai N, Kuniyoshi , Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Inage K, Sainoh T, Yamauchi K, Toyone T, Nakamura J, Kishida S, Sato J, Takahashi

  • KMID: 2386481
  • Yonsei Med J.
  • 2014 Mar;55(2):487-492.
PURPOSE: Bupivacaine is commonly used for the treatment of back pain and the diagnosis of its origin. Nonunion is sometimes observed after spinal fusion surgery; however, whether the nonunion causes...
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Progressive Change in Joint Degeneration in Patients with Knee or Hip Osteoarthritis Treated with Fentanyl in a Randomized Trial

Fujii T, Takana K, Orita S, Inoue G, Ochiai N, Kuniyoshi , Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Yamauchi K, Toyone T, Nakamura J, Kishida S, Takahashi , Ohtori S

PURPOSE: Opioids improve pain from knee and hip osteoarthritis (OA) and decrease the functional impairment of patients. However, there is a possibility that opioids induce analgesia and suppress the physiological...
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More than 6 Months of Teriparatide Treatment Was More Effective for Bone Union than Shorter Treatment Following Lumbar Posterolateral Fusion Surgery

Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kuniyoshi , Aoki Y, Nakamura J, Miyagi M, Suzuki M, Kubota G, Inage K, Sainoh T, Sato J, Shiga Y, Abe K, Fujimoto K, Kanamoto H, Inoue G, Takahashi

STUDY DESIGN: Retrospective case series. PURPOSE: To examine the most effective duration of teriparatide use for spinal fusion in women with postmenopausal osteoporosis. OVERVIEW OF LITERATURE: We reported that daily subcutaneous injection...
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Mini-Open Anterior Retroperitoneal Lumbar Interbody Fusion: Oblique Lateral Interbody Fusion for Lumbar Spinal Degeneration Disease

Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Aoki Y, Nakamura J, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Sato J, Fujimoto K, Shiga Y, Abe K, Toyone T, Inoue G, Takahashi

PURPOSE: Surgery for lumbar spinal degeneration disease is widely performed. While posterior decompression and fusion are popular, anterior lumbar interbody fusion (ALIF) is also used for treatment. Extreme lateral interbody...
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Efficacy of Combination of Meloxicam and Pregabalin for Pain in Knee Osteoarthritis

Ohtori S, Inoue G, Orita S, Takaso M, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Suzkuki M, Nakamura J, Kubota G, Sakuma Y, Oikawa Y, Toyone T, Inage K, Sainoh T, Yamauchi K, Takahashi

PURPOSE: Osteoarthritic pain is largely considered to be inflammatory pain. Sensory nerve fibers innervating the knee have been shown to be significantly damaged in rat models of knee osteoarthritis (OA)...
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Existence of a Neuropathic Pain Component in Patients with Osteoarthritis of the Knee

Ohtori S, Orita S, Yamashita , Ishikawa T, Ito T, Shigemura , Nishiyama , Konno S, Ohta H, Takaso M, Inoue G, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Aoki Y, Arai G, Miyagi M, Kamoda H, Suzkuki M, Nakamura J, Furuya T, Kubota G, Sakuma Y, Oikawa Y, Suzuki M, Sasho T, Nakagawa K, Toyone T, Takahashi

PURPOSE: Pain from osteoarthritis (OA) is generally classified as nociceptive (inflammatory). Animal models of knee OA have shown that sensory nerve fibers innervating the knee are significantly damaged with destruction...
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Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis

Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Aoki Y, Nakamura J, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Sato J, Shiga Y, Abe K, Fujimoto K, Kanamoto H, Toyone T, Inoue G, Takahashi

PURPOSE: Osteoarthritic (OA) pain is largely considered to be inflammatory pain. However, during the last stage of knee OA, sensory nerve fibers in the knee are shown to be significantly...
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Mini-Open Anterior Retroperitoneal Lumbar Interbody Fusion: Oblique Lateral Interbody Fusion for Degenerated Lumbar Spinal Kyphoscoliosis

Ohtori S, Mannoji C, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Aoki Y, Nakamura J, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Sato J, Shiga Y, Abe K, Fujimoto K, Kanamoto H, Toyone T, Inoue G, Takahashi

STUDY DESIGN: Prospective case series. PURPOSE: To examine the clinical efficacy of mini-open anterior retroperitoneal lumbar interbody fusion: oblique lateral interbody fusion (OLIF) for degenerated lumbar spinal kyphoscoliosis. OVERVIEW OF LITERATURE: The...
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Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

Nojima D, Inage K, Sakuma Y, Sato J, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kuniyoshi , Aoki Y, Nakamura J, Miyagi M, Suzuki M, Kubota G, Sainoh T, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue G, Takahashi , Ohtori S

PURPOSE: The pathophysiology of discogenic low back pain is not fully understood. Tetrodotoxin-sensitive voltage-gated sodium (NaV) channels are associated with primary sensory nerve transmission, and the NaV1.7 channel has emerged...
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