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Trends in Chemotherapy Patterns and Survival of Patients with Advanced Gastric Cancer over a 16-Year Period: Impact of Anti-HER2–Targeted Agent in the Real-World Setting

Koo DH, Ryu MH, Lee MY, Chae H, Kim EJ, Moon MS, Kang YK

Purpose This study aimed to evaluate the survivals of patients with metastatic or recurrent gastric cancer (MRGC) over a period of 16 years and to investigate the recent changes in chemotherapy...
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Ramosetron versus Palonosetron in Combination with Aprepitant and Dexamethasone for the Control of Highly-Emetogenic Chemotherapy-Induced Nausea and Vomiting

Kang JH, Kwon JH, Lee YG, Park KU, An HJ, Sohn J, Seol YM, Lee H, Yun HJ, Ahn JS, Yang JH, Song H, Koo DH, Kim JY, Kim GM, Kim HJ

Purpose The purpose of this study was to compare ramosetron (RAM), aprepitant (APR), and dexamethasone (DEX) [RAD] with palonosetron (PAL), APR, and DEX [PAD] in controlling highly-emetogenic chemotherapy (HEC)–induced nausea and...
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Initial titration with 200 μg fentanyl buccal tablets: a retrospective safety analysis in Korean cancer patients

Kwon MY, Cho HN, Koo DH, Lee YG, Oh S, Lee SS

BACKGROUND/AIMS: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset...
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Practice Patterns Regarding Multidisciplinary Cancer Management and Suggestions for Further Refinement: Results from a National Survey in Korea

Lee YG, Oh S, Kimm H, Koo DH, Kim DY, Kim BS, Lee SS

PURPOSE: This study was conducted to explore the process and operation of a cancer multidisciplinary team (MDT) after the reimbursement decision in Korea, and to identify ways to overcome the...
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Field Cancerization in Sporadic Colon Cancer

Park SK, Song CS, Yang HJ, Jung YS, Choi KY, Koo DH, Kim KE, Jeong KU, Kim HO, Kim H, Chun HK, Park DI

BACKGROUND/AIMS: Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor 2 (TFPI2), N-Myc downstream-regulated gene 4...
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Erratum: Field Cancerization in Sporadic Colon Cancer

Park SK, Song CS, Yang HJ, Jung YS, Choi KY, Koo DH, Kim KE, Jeong KU, Kim HO, Kim H, Chun HK, Park DI

In the version of this article initially published, the first affiliation (affiliation number 1) was incorrectly stated as "Division of Gastroentorology, Department of Internal Medicine." The correct affiliation is "Department...
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Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor

Koo DH, Ryu MH, Kim KM, Yang HK, Sawaki A, Hirota S, Zheng J, Zhang B, Tzen CY, Yeh CN, Nishida T, Shen L, Chen LT, Kang YK

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors originating in the gastrointestinal tract. With the introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these tumors...
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Ethical Attitudes according to Education and Clinical Experience of Do-Not-Resuscitate (DNR)

Kae YA, Lee MY, Park JS, Kim HJ, Jung TY, Jang BY, Kim YJ, Koo DH

PURPOSE: Although a Do-Not-Resuscitate (DNR) order is widely in use, it is one of the challenging issues in end-of-life care. This study was conducted to investigate attitudes toward DNR according...
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Clinical Outcome of Remnant Thyroid Ablation with Low Dose Radioiodine in Korean Patients with Low to Intermediate-risk Thyroid Cancer

Ha S, Oh SW, Kim YK, Koo DH, Jung YH, Yi KH, Chung JK

Radioiodine activity required for remnant thyroid ablation is of great concern, to avoid unnecessary exposure to radiation and minimize adverse effects. We investigated clinical outcomes of remnant thyroid ablation with...
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Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-gamma Stimulated HaCaT Human Keratinocytes

Kang NJ, Koo DH, Kang GJ, Han SC, Lee BW, Koh YS, Hyun JW, Lee NH, Ko MH, Kang HK, Yoo ES

Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22...
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Early outcome of the Korean Diagnosis-Related Groups payment system for appendectomy

Kim H, Jung IM, Yun KW, Heo SC, Ahn YJ, Hwang KT, Lee HW, Koo DH, Ko E, Ahn HS, Shin R, Chung JK

PURPOSE: The implementation of the Korean diagnosis-related groups (DRG) payment system has been recently introduced in selected several diseases including appendectomy in Korea. Here, we report the early outcomes with...
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Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study

Chai YJ, Hong JH, Koo DH, Yu HW, Lee JH, Kwon H, Kim SJ, Choi JY, Lee KE

PURPOSE: Primary thyroid lymphoma (PTL) is a rare disease and it has been investigated in a limited number of studies. The present multicenter study evaluated the clinical features and treatment...
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A Rare Case of Acute Leukemic Presentation of Blastic Plasmacytoid Dendritic Cell Neoplasm without Cutaneous Lesions

Yu S, Kwon MJ, Kim K, Koo DH, Woo HY, Park H

No abstract available.
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Long-term Follow-up of Hb Madrid Patient

Koo DH, Oh S, Kim HJ, Jung HL

  • KMID: 2049293
  • Clin Pediatr Hematol Oncol.
  • 2013 Apr;20(1):55-58.
We report a long-term follow-up of unstable hemoglobin (Hb) patient. He was diagnosed as Hb Madrid [beta115(G17)Ala-->Pro] by direct DNA sequencing and restriction enzyme analysis. Hydroxyurea had been given for...
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Burnt-out Metastatic Prostate Cancer

Shin DS, Koo DH, Yoo S, Ju DY, Jang CM, Joo KJ, Shin HC, Chae SW

  • KMID: 2320025
  • Yeungnam Univ J Med.
  • 2013 Dec;30(2):116-119.
A burnt-out prostate cancer tumor is a very rare clinical entity. The term 'burnt-out' refers to a primary tumor that has spontaneously and nearly completely regressed without treatment. Since metastasis...
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Diagnosis and Treatment of Gastrointestinal Stromal Tumor

Kang YK, Koo DH

  • KMID: 2267783
  • Korean J Med.
  • 2013 Oct;85(4):341-353.
Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the gastrointestinal tract, have represented an important advance in oncology field with the success of molecular targeted therapy....
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An exclusively dopamine secreting paraganglioma in the retroperitoneum: a first clinical case in Korea

Yi JW, Oh EM, Lee KE, Choi JY, Koo DH, Kim KJ, Jung KC, Kim SY, Youn YK

  • KMID: 2324841
  • J Korean Surg Soc.
  • 2012 Jun;82(6):389-393.
Exclusively dopamine producing retroperitoneal paragangliomas are extremely rare. We have experienced the first Korean case managed successfully based on the proper evaluation. A 26-year-old female patient came to our attention...
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Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis

Song JY, Bae HS, Koo DH, Lee JK, Jung HH, Lee KW, Lee NW

Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study...
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The Chloroform Fraction of Carpinus tschonoskii Leaves Inhibits the Production of Inflammatory Mediators in HaCaT Keratinocytes and RAW264.7 Macrophages

Kang GJ, Kang NJ, Han SC, Koo DH, Kang HK, Yoo BS, Yoo ES

  • KMID: 1432309
  • Toxicol Res.
  • 2012 Dec;28(4):255-262.
Inflammation is the immune system's response to infection and injury-related disorders, and is related to pro-inflammatory factors (NO, PGE2, cytokines, etc.) produced by inflammatory cells. Atopic dermatitis (AD) is a...
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Usage Patterns of Surveillance, Chemoprevention and Risk-Reducing Surgery in Korean BRCA Mutation Carriers: 5 Years of Experience at a Single Institution

Koo DH, Chung IY, Kang E, Han SA, Kim SW

PURPOSE: Options for BRCA mutation carriers include close surveillance, chemoprevention, and risk-reducing surgery (RRS) for breast and ovarian cancer. However, chemoprevention and RRS for cancer prevention are not widely performed...
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