Korean J Med.  2013 Oct;85(4):341-353.

Diagnosis and Treatment of Gastrointestinal Stromal Tumor

• Kang YK
• Koo DH

Abstract

Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the gastrointestinal tract, have represented an important advance in oncology field with the success of molecular targeted therapy. Since the approval of the tyrosine kinase inhibitor (imatinib) in 2002, the survival of patients with advanced GISTs has significantly increased. Accurate histopathologic diagnosis of GISTs and multidisciplinary approach has become more important for successful management of GISTs. Recently, imatinib has become a standard treatment even in adjuvant setting, and regorafenib has been approved for advanced GIST after failure of imatinib and sunitinib. This review presents here the updated results of relevant clinical studies for the further revision to the guideline of Korean GIST study group. We hope this review will help enhance the quality of diagnosis, treatment, and care of patients with GIST in Korea.

Keyword

GIST; Diagnosis; Treatment; Imatinib; Sunitinib; Regorafenib

MeSH Terms

Benzamides
Gastrointestinal Stromal Tumors
Gastrointestinal Tract
Humans
Indoles
Korea
Molecular Targeted Therapy
Phenylurea Compounds
Piperazines
Protein-Tyrosine Kinases
Pyridines
Pyrimidines
Pyrroles
Imatinib Mesylate
Benzamides
Indoles
Phenylurea Compounds
Piperazines
Protein-Tyrosine Kinases
Pyridines
Pyrimidines
Pyrroles