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Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers

Kondo Y

DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in...
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Health-Related Quality of Life is Associated With Pain, Kinesiophobia, and Physical Activity in Individuals Who Underwent Cervical Spine Surgery

Higuchi D, Kondo Y, Watanabe Y, Miki T

Objective: To determine the association between health-related quality of life (HRQOL) and neck pain, kinesiophobia, and modalities of physical activity in individuals with postoperative degenerative cervical myelopathy and radiculopathy (DCM/R)...
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Effects of Central Sensitivity Syndrome and Psychological Factors on the Clinical Features of Patients with Cervical Degenerative Disease: A Cross-Sectional Study

Kondo Y, Miki T, Higuchi D, Takebayashi T

Study Design: Single-center cross-sectional study. Purpose: The present study aimed to clarify the effects of central sensitivity syndrome (CSS) and psychological factors on the clinical features in patients with cervical degenerative...
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Chronic Stress Induces Neurotrophin-3 in Rat Submandibular Gland

Saruta J, Iida M, Kondo Y, To M, Hayashi T, Hori M, Sato S, Tsukinoki

PURPOSE: Plasma neurotrophin-3 (NT-3) levels are associated with several neural disorders. We previously reported that neurotrophins were released from salivary glands following acute immobilization stress. While the salivary glands were...
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Predictive Factors for Intractability to Endoscopic Hemostasis in the Treatment of Bleeding Gastroduodenal Peptic Ulcers in Japanese Patients

Ogasawara , Mizuno M, Masui R, Kondo Y, Yamaguchi , Yanamoto K, Noda H, Okaniwa N, Sasaki M, Kasugai K

BACKGROUND/AIMS: Despite improvements in endoscopic hemostasis and pharmacological therapies, upper gastrointestinal (UGI) ulcers repeatedly bleed in 10% to 20% of patients, and those without early endoscopic reintervention or definitive surgery...
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Efficacy of restarting anti-tumor necrosis factor α agents after surgery in patients with Crohn's disease

Hiraoka S, Takashima , Kondo Y, Inokuchi T, Sugihara Y, Takahara M, Kawano S, Harada K, Kato J, Okada H

BACKGROUND/AIMS: The efficacy of anti-tumor necrosis factor α (anti-TNFα) antibodies for postoperative Crohn's disease (CD) in patients who were treated with these agents prior to surgery is largely unknown. METHODS: CD...
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