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The Role of Heat Shock Response in Insulin Resistance and Diabetes

Kondo T, Motoshima , Igata M, Kawashima , Matsumura , Kai H, Araki E

The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in...
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Fungemia due to Trichosporon dermatis in a patient with refractory Burkitt's leukemia

Hashino S, Takahashi , Morita R, Kanamori H, Onozawa M, Kawamura T, Kahata K, Kondo T, Tokimatsu , Sugita T, Akizawa K, Asaka M

No abstract available.
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Key Imaging Findings for the Prospective Diagnosis of Rare Diseases of the Gallbladder and Cystic Duct

Ichikawa S, Oishi N, Kondo T, Onishi H

There are various diseases of the gallbladder and cystic duct, and imaging diagnosis is challenging for the rare among them. However, some rare diseases show characteristic imaging findings or patient...
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Esophageal Sensation and Esophageal Hypersensitivity: Overview From Bench to Bedside

Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J

  • KMID: 2204231
  • J Neurogastroenterol Motil.
  • 2010 Oct;16(4):353-362.
Noxious stimuli in the esophagus activate nociceptive receptors on esophageal mucosa, such as transient receptor potential, acid-sensing ion channel and the P2X family, a family of ligand-gated ion channels responsive...
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Safety and efficacy of endoscopic ultrasound-guided pancreatic duct drainage using a drill dilator: a retrospective study in Japan

Sadek A, Hara K, Okuno N, Haba S, Kuwahara T, Fukui T, Urata M, Kondo T, Yamamoto Y, Tachi K

Background/Aims: Dilation of the tract before stent deployment is a challenging step in endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD). In this study, we examined the effectiveness and safety of a...
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Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey

Tamura A, Tomita T, Oshima T, Toyoshima , Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ikehara H, Ohda Y, Fukui H, Watari J, Miwa H

  • KMID: 2433461
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):677-685.
  • doi: 10.5056/jnm15187
BACKGROUND/AIMS: Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits...
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Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia

Duan S, Imamura N, Kondo T, Kanda H, Kogure Y, Okugawa T, Fukushima M, Tomita T, Oshima T, Fukui H, Noguchi K, Dai Y, Miwa H

  • KMID: 2528040
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):255-264.
  • doi: 10.5056/jnm21204
Background/Aims Herbal medicine is an important complementary therapy for functional dyspepsia (FD). However, its effect against gastric hypersensitivity in patients with FD has rarely been evaluated. Yokukansan (YKS), a traditional Japanese...
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Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia

Kuroda S, Kondo T, Mori K, Yasuda K, Asai T, Sanjo H, Yakanaka H, Takeshima , Kawahara T, Kato Y, Miyoshi Y, Uemura H, Iwasaki A, Yumura Y

Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a...
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Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry

Yamasaki T, Tomita T, Mori S, Takimoto M, Tamura A, Hara K, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H

  • KMID: 2417384
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):403-409.
  • doi: 10.5056/jnm17147
BACKGROUND/AIMS: High-resolution esophageal manometry (HREM) is considered to be the gold standard for the diagnosis of achalasia. However, the Japan Esophageal Society recommends that esophagography is also accurate in either...
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Incidence and Characteristics of Clinical L5–S1 Adjacent Segment Degeneration after L5 Floating Lumbar Fusion: A Multicenter Study

Takegami N, Akeda K, Yamada J, Imanishi T, Fujiwara T, Kondo T, Takegami K, Sudo A

Study Design: Retrospective study. Purpose: This study aimed to evaluate the incidence, characteristics, and risk factors for clinical L5–S1 adjacent segment degeneration (ASD) after L5 floating lumbar fusion. Overview of Literature: ASD...
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Switching to systemic therapy after locoregionaltreatment failure: Definition and best timing

Ogasawara , Ooka Y, Koroki K, Maruta S, Kanzaki H, Kanayama K, Kobayashi , Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Tawada A, Chiba T, Arai M, Kato J, Kato N

In patients with unresectable hepatocellular carcinoma (HCC) without both macrovascular invasion and extrahepatic metastasis, the initial treatment choice recommended is transarterial chemoembolization (TACE). Before sorafenib came into wide use, TACE...
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Impact of preoperative proteinuria on renal functional outcomes after open partial nephrectomy in patients with a solitary kidney

Tachibana , Kondo T, Takagi T, Okumi M, Tanabe K

PURPOSE: To assess the impact of proteinuria on postoperative renal function after open partial nephrectomy (OPN) in patients with a solitary kidney and analyze predictive factors for developing chronic kidney...
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Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

Asano H, Tomita T, Nakamura K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Fukushima , Hirota S, Watari J, Miwa H

  • KMID: 2387830
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):392-399.
  • doi: 10.5056/jnm16173
BACKGROUND/AIMS: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of...
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Elevated Brain-Derived Neurotrophic Factor Levels During Depressive Mixed States

Otsuka N, Takaesu Y, Zamami Y, Ota K, Kurihara K, Shinzato H, Kondo T

Objective Neurotrophin-like brain-derived neurotrophic factor (BDNF) and pro-inflammatory cytokines may modulate the pathophysiology of mood disorders. Although several studies show alterations in these biomarkers during the depressive, manic, and euthymic...
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Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals

Yamasaki T, Tomita T, Takimoto M, Kondo T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H

  • KMID: 2395420
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):526-532.
  • doi: 10.5056/jnm17067
BACKGROUND/AIMS: When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However,...
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Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)

Kondo T, Yoshida S, Nagai H, Takeshita , Mino M, Morioka H, Nakajima T, Kusakabe K, Okada T

In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet...
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A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation

Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H

  • KMID: 2460486
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):563-575.
  • doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic...
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Prevalence of Irritable Bowel Syndrome–like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Tomita T, Kato Y, Takimoto M, Yamasaki T, Kondo T, Kono T, Tozawa K, Yokoyama Y, Ikehara H, Ohda Y, Oshima T, Fukui H, Tanaka S, Shima M, Watari J, Miwa H

  • KMID: 2433459
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):661-669.
  • doi: 10.5056/jnm15160
BACKGROUND/AIMS: Few studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has...
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