- Cause of Intracellular ATP dependency on Zn2++ Blockade of KATP Channels in Pancreatic Beta Cells
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Ahn YH, Song DK
- KMID: 2298573
- Korean J Aerosp Environ Med.
- 1999 Mar;9(1):77-82.
In order to clarify the cause of intracellular ATP dependency on Zn2+ blockade of KATP channels in pancreatic beta cells, we investigated the KATP channel activity during external Zn2+ application... -
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- Effect of Intracellular ATP on Zn2+ Blockade of KATP Channels in Pancreatic Beta Cells
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Song DK, Bae JH, Hong YS, Park WK
- KMID: 2298571
- Korean J Aerosp Environ Med.
- 1999 Mar;9(1):60-65.
In the therapeutic or the nutritional aspects, Zn2+ has been used as a supplement in a variety of drugs. Most of divalent or trivalent cations affect ion channels in the... -
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- Effect of Cisapride on ATP-sensitive K Channel of Ventricular Cell
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Moon SG, In BH, Kim WH, Ko JK
- KMID: 1894752
- Korean Circ J.
- 1998 Jan;28(1):76-81.
- doi: 10.4070/kcj.1998.28.1.76
BACKGROUND: It has been generally accepted that Cisapride (Prepulsid?or propulsid?), a widely used gastrointestinal prokinetic agent, is associated with Torsades de Points, a life-threatening arrhythmia. Recently, cisapride-induced APD (action potential... -
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- Differential Changes of ATP-sensitive Potassium Channel Current after Hypoxia-reperfusion Treatment in Mouse Neuroblastoma 2a (N2a) Cell
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Park JH
- KMID: 2071578
- Korean J Physiol Pharmacol.
- 2002 Aug;6(4):183-186.
Ischemic damage is one of the most serious problems. The openers of KATP channel have been suggested to have an effect to limit the ischemic damage. However, it is not... -
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- Protein Kinase C Activates ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes
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Kim N, Youm JB, Joo H, Kim H, Kim E, Han J
- KMID: 1600067
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):187-193.
Several signal transduction pathways have been implicated in ischemic preconditioning induced by the activation of ATP-sensitive K+ (KATP) channels. We examined whether protein kinase C (PKC) modulated the activity of... -
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- The effects of intracellular monocarboxylates on the ATP-sensitive potassium channels in rabbit ventricular myocytes
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Kim N, Han J, Kim YE, Ho WK, Earm YE
- KMID: 2071538
- Korean J Physiol Pharmacol.
- 1998 Oct;2(5):581-589.
A regulating mechanism of the ATP-sensitive potassium channels (KATP channels) is yet to fully explained. This study was carried out to investigate the effects of intracellular application of monocarboxylates (acetate, formate, lactate, and... -
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- Effect of propofol, an intravenous anesthetic agent, on KATP channels of pancreatic beta-cells in rats
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Park EJ, Song DK, Cheun JK, Bae JI, Ho WK, Earm YE
- KMID: 1580632
- Korean J Physiol Pharmacol.
- 2000 Feb;4(1):25-31.
ATP-sensitive potassium channels (KATP channels) play an important role in insulin secretion from pancreatic beta cells. We have investigated the effect of propofol on KATP channels in cultured single pancreatic beta cells of... -
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- Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea Receptor
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Proks P
- KMID: 2174288
- Diabetes Metab J.
- 2013 Jun;37(3):157-164.
- doi: 10.4093/dmj.2013.37.3.157
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels in pancreatic beta-cells play a crucial role in insulin secretion and glucose homeostasis. These channels are composed of two subunits: a pore-forming subunit (Kir6.2)... -
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- The Effect of Trifluoroacetic Acid, a Metabolite of Isoflurane on the ATP-sensitive Potassium Channel in Rabbit Ventricular Myocytes
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Lee DJ, Kim SJ, Ha KH, Kim MC, Cho KH
- KMID: 1860647
- Korean J Anesthesiol.
- 2002 Dec;43(6):s1-s12.
- doi: 10.4097/kjae.2002.43.6.s1
BACKGROUND: Activation of ATP-sensitive K+ channels (KATP channels) in the cardiac muscle produces cardioprotective effects during myocardial ischemia. Previous experimental evidence indicates that volatile anesthetics exert beneficial actions in ischemic... -
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- Activation of ATP-sensitive potassium channels by the predominant metabolite of isoflurane in rabbit ventricular myocytes
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Han J, Kim NR, Kim EY, Kim SJ, Cho KH
- KMID: 2285237
- Korean J Physiol Pharmacol.
- 2001 Apr;5(2):165-175.
Background: Recent in vivo experimental evidence suggests that isoflurane-induced cardioprotection may involve KATP channel activation. However, it was demonstrated that isofluran inhibited KATP channel activities in the inside-out patch mode. To explain this discrepancy,... -
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- Vascular Smooth Muscle Adenosine Triphosphate (ATP)-Sensitive Potassium Channel and Anesthetics
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Sohn JT
- KMID: 2238967
- Korean J Anesthesiol.
- 2002 Sep;43(3):263-273.
- doi: 10.4097/kjae.2002.43.3.263
Adenosine triphosphate-sensitive potassium channel (KATP channel) closed by intracellular adenosine triphosphate (ATP) appears widely distributed in the vascular system. Activation of vascular smooth muscle KATP channel with hyperpolarizing agents such... -
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- Opening of ATP-sensitive K+ channel by pinacidil requires serine/threonine phosphorylation in rat ventricular myocytes
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Kwak YG, Chae SW
- KMID: 2285223
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):293-303.
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K+ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches,... -
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- Evidence for the Participation of ATP-sensitive Potassium Channels in the Antinociceptive Effect of Curcumin
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De Paz-Campos MA, Chavez-Pina AE, Ortiz MI, Castaneda-Hernandez G
- KMID: 2278162
- Korean J Pain.
- 2012 Oct;25(4):221-227.
- doi: 10.3344/kjp.2012.25.4.221
BACKGROUND: It has been reported that curcumin, the main active compound of Curcuma longa, also known as turmeric, exhibits antinociceptive properties. The aim of this study was to examine the... -
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- Effect of prostaglandins D2, E2 and I2 on the regulation of KATP channel activity in rat cardiac myocytes
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Ju JM, Nah SY, Kim JH
- KMID: 2071552
- Korean J Physiol Pharmacol.
- 1999 Oct;3(5):507-512.
Contribution of prostaglandins D2, E2 and I2 (PGD2, PGE2 and PGI2) on the regulation of ATP-sensitive K+ channel (KATP channel) was investigated in isolated single rat ventricular cardiac myocytes using the patch clamp... -
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- Expression of ATP-sensitive potassium channel and sulfonylurea receptor in neonate and adult rat tissues
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Lee SY, Lee H, Lee MH, Ryu PD
- KMID: 1607083
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):433-441.
The ATP-sensitive potassium (KATP) channel is a member of inward rectifier potassium channel (Kir) that is inhibited by intracellular ATP and functions in close relation to sulfonylurea receptors (SUR). Although the molecular mechanism... -
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- Influence of Nitric Oxide Donor on the Regulation of ATP-sensitive K+ Channel Activity in Cardiac Myocytes
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Ju JM, Shin DH, Lee WS, Park HW, Cho JG, Kim JH
- KMID: 2116759
- Chonnam Med J.
- 2002 Jun;38(2):135-145.
It was investigated that effects of nitric oxide donors on the ATP-sensitive K+ channel (KATP channel) in isolated mouse ventricular cardiac myocytes using patch clamp techniques. In perforated whole-cell patches,... -
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- ATP-sensitive K+ currents in gastric myocytes isolated from guinea-pig
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Jun JY, Yeum CH, Yun PJ, Park JS, Kim SJ, So I, Kim KW
- KMID: 2071528
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):85-93.
ATP-sensitive K+ channels (KATP) were not identified in gastric smooth muscle cells. However, in tension recording of intact gastric circular muscle, lemakalim of KATP channels opener in other tissues suppressed mechanical contractions and... -
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- Participation of KATP Channels in the Antinociceptive Effect of Pregabalin in Rat Formalin Test
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Kweon TD, Kim JY, Kwon IW, Choi JB, Lee YW
- KMID: 2278100
- Korean J Pain.
- 2011 Sep;24(3):131-136.
- doi: 10.3344/kjp.2011.24.3.131
BACKGROUND: Pregabalin is an anticonvulsant and analgesic agent that interacts selectively with the voltage-sensitive-Ca(2+)-channel alpha-2-delta subunit. The aim of this study was to evaluate whether the analgesic action of intrathecal... -
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- Effects of corticotropin-releasing hormone on the expression of adenosine triphosphate-sensitive potassium channels (Kir6.1/SUR2B) in human term pregnant myometrium
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Kim JY, Wu WH, Jun JH, Sohn J, Seo YS
- KMID: 2420147
- Obstet Gynecol Sci.
- 2018 Jan;61(1):14-22.
- doi: 10.5468/ogs.2018.61.1.14
OBJECTIVE: Corticotropin-releasing hormone (CRH) is a crucial regulator of human pregnancy and parturition. Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are important for regulating myometrial quiescence during pregnancy. We investigated regulatory... -
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- Effects of Oxygen Free Radicals on KATP Channel Activity in Mouse Cardiac Myocytes
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Park HW, Ju JM, Park OY, Park WS, Kim JH, Kim W, Ahn YK, Jeong MH, Park JC, Kim JH, Kang JC, Cho JG
- KMID: 2227245
- Korean Circ J.
- 2003 Dec;33(12):1140-1146.
- doi: 10.4070/kcj.2003.33.12.1140
BACKGROUND AND OBJECTIVE: Oxygen-derived free radicals (OFRs), produced as myocardium is reperfused after ischemic injury, contribute to reversible and irreversible cellular injury. KATP channels, activated by ischemia, have been reported... -
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