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Advances in Preventive and Therapeutic Strategies for Oral Cancer: A Short Review

Ma L, Kim MO

Oral cancer is a major global health concern, with high incidence and mortality rates, especially in high-risk populations. Early diagnosis remains a challenge, and current treatments, such as surgery, radiation,...
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Challenges in Metabolite Biomarkers as Avenues of Diagnosis and Prognosis of Cancer

Sharma NK, Sarode SC, Sekar G, Sonawane K, Bomle D

Given the evolutionary nature of tumor complexities and heterogeneity, the early diagnosis of cancer encounters various challenges. Complexities at the level of metabolite reprogramming are compelling in the background of...
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Shiga Toxin: Emerging Producer Strains, Prophylactic Approaches, and Application in Cancer Therapy

Babolhavaeji K, Ahmadi A, Shokoohizadeh L

Shiga toxin-producing Escherichia coli is the most prevalent bacterial strain responsible for Shiga toxin-related infections. While Shiga toxin is inherently toxic, it has potential therapeutic applications as a component of...
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Identification of Translocon-associated Protein Delta as An Oncogene in Human Colorectal Cancer Cells

Amarakoon D, Lee WJ, Peng J, Lee SH

Identifying the roles of genes in cancer is critical in discovering potential genetic therapies for cancer care. Translocon-associated protein delta (TRAPδ), also known as signal sequence receptor 4 (SSR4), is...
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Evolving Therapeutic Strategies in Esophageal Squamous Cell Carcinoma: Advances and Perspectives

Liu Z, Kim MO

Esophageal squamous cell carcinoma (ESCC) is among the most prevalent forms of esophageal cancer globally, with a particularly high incidence in developing countries. Notably, Asia accounts for approximately 80% of...
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Relationship between Cancer Incidence and Health Behaviors from Ecological Study in Korea

Ko KP

The aim of this ecological study was to examine the correlation between cancer incidence and health behaviors such as smoking, alcohol consumption, and obesity, and investigated whether there were differences...
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Kelch-like ECH-associated Protein 1/Nuclear Factor Erythroid 2-related Factor 2 Pathway and Its Interplay with Oncogenes in Lung Tumorigenesis

Bae T, Kwak MK

Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor regulating cellular redox homeostasis, exhibits a complex role in cancer biology. Genetic mutations in the Kelch-like ECH-associated protein 1 (KEAP1)/NRF2...
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Risk of Lung Cancer and Risk Factors of Lung Cancer in People Infected with Tuberculosis

Hong S, Kim J, Park K, Park B, Choi BY

This study investigated lung cancer risk in people infected with tuberculosis (TB) compared to the general population and evaluated factors associated with lung cancer in TB-infected individuals. Mandatory reported TB...
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Risk of Incident Cancer in Veterans with Diabetes Who Use Metformin Versus Sulfonylureas

Abdallah MM, Oliveira BDd, DuMontier C, Orkaby AR, Nussbaum L, Gaziano M, Djousse L, Gagnon D, Cho K, Preis SR, Driver JA

Prior research suggests metformin has anti-cancer effects, yet data are limited. We examined the association between diabetes treatment (metformin versus sulfonylurea) and risk of incident diabetes-related and non- diabetes-related cancers...
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Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1

Guillen-Quispe YN, Kim SJ, Saeidi S, Choi GJ, Chelakkot C, Zhou T, Bang SB, Kim TW, Shin YK, Surh YJ

Prolyl hydroxylase domain 2 (PHD2) is the primary oxygen sensing enzyme involved in hydroxylation of hypoxia-inducible factor (HIF). Under normoxic conditions, PHD2 hydroxylates specific proline residues in HIF-1α and HIF-2α,...
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Therapeutic Potential of Hongjam in A Diethylnitrosamine and Thioacetamide-induced Hepatocellular Carcinoma Mouse Model

Han YM, Ahn HR, Lee DY, Song MY, Lee SW, Jang YK, Jeon BY, Kim EH

Hepatocellular carcinoma (HCC) is the most common and lethal type of primary liver cancer, frequently arising from chronic liver injury and inflammation. Despite treatment advancements, HCC prognosis remains poor, emphasizing...
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Comparison of GastroPanel® and GENEDIA® in Diagnosing Helicobacter pylori Infection and Gastric Lesions

Choi Y, Kim N, Lim SH, Park JH, Lee JH, Kim Y, Jo H, Lee HK, Choi J, Jun YK, Yoon H, Shin CM, Park YS, Lee DH

Serological tests for Helicobacter pylori needs local validation as the diagnostic accuracy may vary depending on the prevalence of H. pylori. This study examined the diagnostic performance of two ELISA, GastroPanel®...
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