J Cancer Prev.
2024 Dec;29(4):120-128. 10.15430/JCP.24.010.
Shiga Toxin: Emerging Producer Strains, Prophylactic Approaches, and Application in Cancer Therapy
- Affiliations
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- 1Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
- 2Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
- 3Infectious Disease Research Center, Avicenna Institute of Clinical Sciences, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
- KMID: 2564113
- DOI: http://doi.org/10.15430/JCP.24.010
Abstract
- Shiga toxin-producing Escherichia coli is the most prevalent bacterial strain responsible for Shiga toxin-related infections. While Shiga toxin is inherently toxic, it has potential therapeutic applications as a component of anticancer drugs. Despite its association with infections and harmful effects on human health, Shiga toxin is being explored as a viable element in drug delivery systems targeting cancer cells. The findings indicate that the production of mutated bacteria containing Shiga toxin is an effective preventive strategy for immunization against these toxins. Furthermore, the B subunit of Shiga toxin shows promise for imaging cancer cells, opening new paths for therapeutic interventions.
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